Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Morag R. Hunter"'
Autor:
Dania Grant-Serroukh, Morag R. Hunter, Ruhina Maeshima, Aristides D. Tagalakis, Ahmad M. Aldossary, Nour Allahham, Gareth R. Williams, Mark Edbrooke, Arpan Desai, Stephen L. Hart
Publikováno v:
Journal of Controlled Release. 348:786-797
Despite recent advances in the field of mRNA therapy, the lack of safe and efficacious delivery vehicles with pharmaceutically developable properties remains a major limitation. Here, we describe the systematic optimisation of lipid-peptide nanocompl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02155699f3ec764ea0f716a208dec4e
https://doi.org/10.1016/j.jconrel.2022.06.018
https://doi.org/10.1016/j.jconrel.2022.06.018
Autor:
Beverley Isherwood, Samantha Peel, Uchechukwu Odunze, Himjyot Jaiswal, Douglas Ross-Thriepland, Davide Gianni, Arpan Desai, Morag R. Hunter, Larissa Butler, Aurélie Bornot
Publikováno v:
Slas Discovery
Modified messenger RNAs (mRNAs) hold great potential as therapeutics by using the body's own processes for protein production. However, a key challenge is efficient delivery of therapeutic mRNA to the cell cytosol and productive protein translation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f28286f6157ecd23263262041ebb24
https://pubmed.ncbi.nlm.nih.gov/32441189
https://pubmed.ncbi.nlm.nih.gov/32441189
Autor:
Lili Cui, Morag R. Hunter, Silvia Sonzini, Sara Pereira, Steven M. Romanelli, Kai Liu, Weimin Li, Lihuan Liang, Bin Yang, Najet Mahmoudi, Arpan S. Desai
Publikováno v:
Small. 18:2105832
Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for COVID-19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which enable functional intracellular delivery. Previously, the authors est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078cbbf26c2907eca1ca63e043d02e65
https://doi.org/10.1002/smll.202105832
https://doi.org/10.1002/smll.202105832
Autor:
Anisha Korde, Michelle Glass, David B. Finlay, V. Kiran Vemuri, Morag R. Hunter, Natasha L. Grimsey, Erin E. Cawston, Alexandros Makriyannis
Publikováno v:
British Journal of Pharmacology. 174:2545-2562
BACKGROUND AND PURPOSE CB1 cannabinoid receptor signalling is canonically mediated through inhibitory Gαi proteins, but signalling through other G proteins occurs under some circumstances; Gαs being the most characterised secondary pathway. Determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c705649b33259248751c402a54de29
https://doi.org/10.1111/bph.13866
https://doi.org/10.1111/bph.13866
Publikováno v:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 374(1765)
Nucleic acids are a rapidly emerging therapeutic modality with the potential to become the third major drug modality alongside antibodies and small molecules. Owing to the unfavourable physico-chemical characteristics of nucleic acids, such as large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ee44350682a58ab523063c8e296ffc
https://pubmed.ncbi.nlm.nih.gov/30967005
https://pubmed.ncbi.nlm.nih.gov/30967005
Autor:
Benjamin T. Porebski, Daniel Christ, Morag R. Hunter, Peter R. Schofield, Rodrigo Vazquez-Lombardi, Ashley M. Buckle, Paul J. Conroy, Sheena McGowan, David E. Hoke, Nyssa Drinkwater
Publikováno v:
Protein Engineering, Design and Selection
The favorable biophysical attributes of non-antibody scaffolds make them attractive alternatives to monoclonal antibodies. However, due to the well-known stability-function trade-off, these gains tend to be marginal after functional selection. A nota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ed3a606f58d968236cc1ca9b67bd63
http://europepmc.org/articles/PMC5081044
http://europepmc.org/articles/PMC5081044
Autor:
Benjamin T. Porebski, Ashley M. Buckle, Geoffrey I. Webb, Adrian A. Nickson, David E. Hoke, Sheena McGowan, Liguang Zhu, Morag R. Hunter
Publikováno v:
Protein Engineering, Design and Selection
Consensus protein design is a rapid and reliable technique for the improvement of protein stability, which relies on the use of homologous protein sequences. To enhance the stability of a fibronectin type III (FN3) domain, consensus design was employ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427ee9aa8a15806db7cde26ef7ba059f
https://doi.org/10.1093/protein/gzv002
https://doi.org/10.1093/protein/gzv002
Autor:
Morag R. Hunter, Michelle Glass
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 71:42-45
Introduction: The detection of cAMP signalling is a common endpoint in the study of G-protein coupled receptors. A number of commercially available kits enable easy detection of cAMP. These kits are based on competition for a cAMP binding site on an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3d4a42c38efb8d10b61f26617303c5
https://doi.org/10.1016/j.vascn.2014.10.008
https://doi.org/10.1016/j.vascn.2014.10.008
Proteomic and biochemical comparison of the cellular interaction partners of human VPS33A and VPS33B
Multi-subunit tethering complexes control membrane fusion events in eukaryotic cells. CORVET and HOPS are two such multi-subunit tethering complexes, both containing the Sec1/Munc18 protein subunit VPS33A. Metazoans additionally possess VPS33B, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b7c292712e2d3c96eff28f1a04faeb
Autor:
Morag R, Hunter, David B, Finlay, Christa E, Macdonald, Erin E, Cawston, Natasha L, Grimsey, Michelle, Glass
Publikováno v:
Methods in enzymology. 593
Cannabinoid receptors, like other GPCRs, signal via a spectrum of related signaling pathways. Recently, monitoring GPCR-mediated cAMP signaling has become significantly easier with the development of genetically encoded, transfectable cAMP biosensors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a548b62231672d70dfb72b06b37bf499
https://pubmed.ncbi.nlm.nih.gov/28750814
https://pubmed.ncbi.nlm.nih.gov/28750814