Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Morag J. Young"'
Autor:
Monica Kanki, Artika P. Nath, Ruidong Xiang, Stephanie Yiallourou, Peter J. Fuller, Timothy J. Cole, Rodrigo Cánovas, Morag J. Young
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Disrupted circadian rhythms have been linked to an increased risk of hypertension and cardiovascular disease. However, many studies show inconsistent findings and are not sufficiently powered for targeted subgroup analyses. Using the UK Biob
Externí odkaz:
https://doaj.org/article/e6d31206a7c94d4d87347ab8e8d4bf47
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/0e476c5989094c329a3254fbb023358a
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The global burden of ischemic heart disease is burgeoning for both men and women. Although advances have been made, the need for new sex-specific therapies targeting key differences in cardiovascular disease outcomes in men and women remains. Mineral
Externí odkaz:
https://doaj.org/article/2ca3a299e4684040a85af5ca9f50011c
Autor:
Tram B. Doan, Vanessa Cheung, Colin D. Clyne, Heidi N. Hilton, Natalie Eriksson, Morag J. Young, John W. Funder, George E. O. Muscat, Peter J. Fuller, Christine L. Clarke, J. Dinny Graham
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-16 (2020)
Abstract Background The role of nuclear receptors in both the aetiology and treatment of breast cancer is exemplified by the use of the oestrogen receptor (ER) as a prognostic marker and treatment target. Treatments targeting the oestrogen signalling
Externí odkaz:
https://doaj.org/article/d75a54fc0c0d4205964f8c51ddcf97ff
Autor:
Sandra L. Burke, Benjamin Barzel, Kristy L. Jackson, Cindy Gueguen, Morag J. Young, Geoffrey A. Head
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The hypothalamic paraventricular nucleus (PVN) is an important site where an interaction between circulating angiotensin (Ang) and mineralocorticoid receptor (MR) activity may modify sympathetic nerve activity (SNA) to influence long-term elevation o
Externí odkaz:
https://doaj.org/article/c4e2bad8926a47b6a97b4c7c441c76b2
Autor:
Christine B. Bui, Magdalena Kolodziej, Emma Lamanna, Kirstin Elgass, Arvind Sehgal, Ina Rudloff, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Maurice A. G. M. Kroon, Steven X. Cho, Anton Maksimenko, Marian Cholewa, Philip J. Berger, Morag J. Young, Jane E. Bourke, James T. Pearson, Marcel F. Nold, Claudia A. Nold-Petry
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Pulmonary hypertension secondary to bronchopulmonary dysplasia (BPD-PH) represents a major complication of BPD in extremely preterm infants for which there are currently no safe and effective interventions. The abundance of interleukin-1 (IL-1) is st
Externí odkaz:
https://doaj.org/article/4cf373f5de034ebeae37df5fe137e7df
Autor:
Greg H. Tesch, Morag J. Young
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Activation of the mineralocorticoid receptor (MR) plays important roles in both physiological and pathological events. Blockade of MR signaling with MR antagonists (MRAs) has been used clinically to treat kidney and cardiac disease associated with hy
Externí odkaz:
https://doaj.org/article/08958645ec0e49b5a827be8e073debd8
Autor:
Ellen Menkhorst, Wei Zhou, Leilani Santos, Jian-Guo Zhang, Yves St-Pierre, Morag J. Young, Evdokia Dimitriadis
Publikováno v:
Pregnancy Hypertension. 30:130-136
Preeclampsia is a life-threatening disorder of pregnancy unique to humans. Poor placentation in the first trimester of pregnancy is widely accepted to be an underlying cause of preeclampsia. Galectin-7 is abnormally elevated in chorionic villous samp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddc24f3180ac02309bd01d734e15766
https://doi.org/10.1016/j.preghy.2022.09.008
https://doi.org/10.1016/j.preghy.2022.09.008
Publikováno v:
Journal of Endocrinology. 253:R65-R76
The mineralocorticoid receptor is a steroid hormone receptor that is well known for its involvement in fluid and electrolyte homeostasis in epithelial cells present in the distal nephron. The inappropriate activation of this receptor is now known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1f3ee8cc9d960b762869468704aa2b
https://doi.org/10.1530/joe-21-0323
https://doi.org/10.1530/joe-21-0323
Autor:
Morag J. Young, Nancy Weigel, Marc Tetel, Carol A. Sartorius, Jennifer K. Richer, Robert H. Oakley, Carol A. Lange, Sean Hartig, Sandra L. Grimm, Peter Fuller, Dean P. Edwards, John Cidlowski, Derek Cain
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [75, 218, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids (estrone an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebf16bab28044812b32369d76cbf14d0
https://doi.org/10.2218/gtopdb/f98/2023.1
https://doi.org/10.2218/gtopdb/f98/2023.1