Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Morag C. Martin"'
Caspase-9 plays a critical role in the initiation of apoptosis by the mitochondrial pathway. Activation of caspase-9 is inhibited by phosphorylation at Thr125 by ERK1/2 MAPKs in response to growth factors. Here, we show that phosphorylation of this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8885d0381734d627cf612eb8c58330df
https://doi.org/10.1074/jbc.m705647200
https://doi.org/10.1074/jbc.m705647200
Publikováno v:
Cellular Microbiology
Summary F1L is a functional Bcl-2 homologue that inhibits apoptosis at the mitochondria during vaccinia infection. However, the extent and timing of cell death during DF1L virus infection suggest that additional viral effectors cooperate with F1L to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86c1c98e1abe2c3388092f538ee6cbc
http://europepmc.org/articles/PMC2730480
http://europepmc.org/articles/PMC2730480
Autor:
Nick Morrice, Michelle Lickrish, Catherine Sampson, Paul Clarke, Lindsey A. Allan, Morag C. Martin
Publikováno v:
Journal of Biological Chemistry. 280:15449-15455
The cyclic AMP signal transduction pathway modulates apoptosis in diverse cell types, although the mechanism is poorly understood. A critical component of the intrinsic apoptotic pathway is caspase-9, which is activated by Apaf-1 in the apoptosome, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe43e7ab58f58be967c3cd37030eabe9
https://doi.org/10.1074/jbc.m414325200
https://doi.org/10.1074/jbc.m414325200
Publikováno v:
Journal of Biological Chemistry. 276:45041-45050
The second messenger molecule cyclic AMP dramatically modulates the apoptotic program in a wide variety of cells, accelerating apoptosis in some and delaying the rate of apoptosis in others. Human neutrophil apoptosis, a process that regulates the fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f34839d4bde18c79df045cc9c86b07a
https://doi.org/10.1074/jbc.m105197200
https://doi.org/10.1074/jbc.m105197200
Autor:
Ana L. Alessandri, Adriano G. Rossi, Hugh J.M. Brady, John M. Hallett, Rodger Duffin, Mauro M. Teixeira, Sarah Fox, Tara A. Sheldrake, Morag C. Martin, Colette Meyer, Christopher Haslett, Andrew E. Leitch, Ian Dransfield
Publikováno v:
FEBS letters. 583(15)
Eosinophils are major players in inflammatory allergic diseases such as asthma, hay fever and eczema. Here we show that the cyclin-dependent kinase inhibitor (CDKi) R-roscovitine efficiently and rapidly induces human eosinophil apoptosis using flow c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c936692fb9b5d13edff5a5963ea2c0
https://pubmed.ncbi.nlm.nih.gov/19616548
https://pubmed.ncbi.nlm.nih.gov/19616548
Autor:
Morag C. Martin, Annemieke Walker, Rodger Duffin, Deborah A. Sawatzky, Adriano G. Rossi, Trevor R. Walker, Elvira Crescenzi, Alison Caldicott, Christopher Haslett, Nicola A. Riley, Tara A. Sheldrake, Ian Dransfield, Mohini Gray, John Savill, Hugh J.M. Brady, Magdalena Martinez-Losa, Carol Ward
Publikováno v:
Nature medicine
12 (2006): 1056–1064. doi:10.1038/nm1468
info:cnr-pdr/source/autori:Rossi AG; Sawatzky DA; Walker A; Ward C; Sheldrake TA; Riley NA; Caldicott A; Martinez-Losa M; Walker TR; Duffin R; Gray M; Crescenzi E; Martin MC; Brady HJ; Savill JS; Dransfield I; Haslett C./titolo:Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis/doi:10.1038%2Fnm1468/rivista:Nature medicine (Print)/anno:2006/pagina_da:1056/pagina_a:1064/intervallo_pagine:1056–1064/volume:12
12 (2006): 1056–1064. doi:10.1038/nm1468
info:cnr-pdr/source/autori:Rossi AG; Sawatzky DA; Walker A; Ward C; Sheldrake TA; Riley NA; Caldicott A; Martinez-Losa M; Walker TR; Duffin R; Gray M; Crescenzi E; Martin MC; Brady HJ; Savill JS; Dransfield I; Haslett C./titolo:Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis/doi:10.1038%2Fnm1468/rivista:Nature medicine (Print)/anno:2006/pagina_da:1056/pagina_a:1064/intervallo_pagine:1056–1064/volume:12
Apoptosis is essential for clearance of potentially injurious inflammatory cells and subsequent efficient resolution of inflammation. Here we report that human neutrophils contain functionally active cyclin-dependent kinases (CDKs), and that structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b07eb7c5635449f1b10c3838ae461fe
Autor:
Christopher Haslett, Trevor R. Walker, Annemieke Walker, John Savill, Adriano G. Rossi, Alison Caldicott, Ian Dransfield, Mohini Gray, Magdalena Martinez-Losa, Carol Ward, Rodger Duffin, Nicola A. Riley, Morag C. Martin, Hugh J.M. Brady, Elvira Crescenzi, Deborah A. Sawatzky, Tara A. Sheldrake
Publikováno v:
Nature Medicine. 12:1434-1434
Nature Medicine 12, 1056–1064 (2006); published online 3 September 2006; corrected after print 10 November 2006 In the version of this article initially published, the dose stated for zVAD-fmk administration was incorrect. The methods reported on p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47e9863a40fa5141a493819272ed6273
https://doi.org/10.1038/nm1206-1434
https://doi.org/10.1038/nm1206-1434
Autor:
Sven Bogdan, Raiko Stephan, Theresa Higgins, Michael K. Rosen, Baoyu Chen, Morag C. Martin, Xing Judy Chen, Anna Julia Squarr, David J. Barry, Michael Way
Publikováno v:
Developmental Cell
Summary Ena/VASP proteins and the WAVE regulatory complex (WRC) regulate cell motility by virtue of their ability to independently promote actin polymerization. We demonstrate that Ena/VASP and the WRC control actin polymerization in a cooperative ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e300ddf31b57554324a09a95293f42e