IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat.

Autor: Brunetta HS; Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil.; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Jung AS; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany., Valdivieso-Rivera F; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil., de Campos Zani SC; Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil., Guerra J; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany., Furino VO; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil., Francisco A; Department of Pathology, University of Campinas, Campinas, SP, Brazil., Berçot M; Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, SP, Brazil., Moraes-Vieira PM; Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas, SP, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, SP, Brazil., Keipert S; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Jastroch M; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Martinez LO; LiMitAging Team, Institute of Metabolic and Cardiovascular Diseases, I2MC UMR1297, IHU HealthAge, INSERM, University of Toulouse, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France., Sponton CH; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil., Castilho RF; Department of Pathology, University of Campinas, Campinas, SP, Brazil., Mori MA; Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil. morima@unicamp.br.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil. morima@unicamp.br.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, SP, Brazil. morima@unicamp.br., Bartelt A; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany. alexander.bartelt@med.uni-muenchen.de.; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany. alexander.bartelt@med.uni-muenchen.de.; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany. alexander.bartelt@med.uni-muenchen.de.; German Center for Diabetes Research, Neuherberg, Germany. alexander.bartelt@med.uni-muenchen.de.

Publikováno v: The EMBO journal [EMBO J] 2024 Nov; Vol. 43 (21), pp. 4870-4891. Date of Electronic Publication: 2024 Sep 16.

Inhibition of Crif1 protects fatty acid-induced POMC neuron-like cell-line damage by increasing CPT-1 function.

Autor: Regina-Ferreira L; Obesity and Comorbidities Research Center, São Paulo, Brazil., Valdivieso-Rivera F; Obesity and Comorbidities Research Center, São Paulo, Brazil.; Department of Structural and Functional Biology, Institute of Biology (IB), University of Campinas, São Paulo, Brazil., Angelim MKSC; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, São Paulo, Brazil., Menezes Dos Reis L; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, São Paulo, Brazil., Furino VO; Obesity and Comorbidities Research Center, São Paulo, Brazil., Morari J; Obesity and Comorbidities Research Center, São Paulo, Brazil., Maia de Sousa L; Laboratory of Cytochemistry and Immunocytochemistry, Department of Biochemistry and Tissue Biology, Institute of Biology (IB), University of Campinas, São Paulo, Brazil., Consonni SR; Laboratory of Cytochemistry and Immunocytochemistry, Department of Biochemistry and Tissue Biology, Institute of Biology (IB), University of Campinas, São Paulo, Brazil., Sponton CH; Obesity and Comorbidities Research Center, São Paulo, Brazil.; Department of Structural and Functional Biology, Institute of Biology (IB), University of Campinas, São Paulo, Brazil., Moraes-Vieira PM; Obesity and Comorbidities Research Center, São Paulo, Brazil.; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas, São Paulo, Brazil., Velloso LA; Obesity and Comorbidities Research Center, São Paulo, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation, São Paulo, Brazil.

Publikováno v: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2024 May 01; Vol. 326 (5), pp. E681-E695. Date of Electronic Publication: 2024 Apr 10.

A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection.

Autor: Narayanan SA; COVID-19 International Research Team, Medford, MA, 02155, USA. anarayan09@gmail.com.; Department of Health, Nutrition and Food Sciences, Florida State University, Tallahassee, FL, 32301, USA. anarayan09@gmail.com., Jamison DA Jr; COVID-19 International Research Team, Medford, MA, 02155, USA., Guarnieri JW; COVID-19 International Research Team, Medford, MA, 02155, USA.; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Zaksas V; COVID-19 International Research Team, Medford, MA, 02155, USA.; Center for Translational Data Science, University of Chicago, Chicago, IL, 60637, USA.; Clever Research Lab, Springfield, IL, 62704, USA., Topper M; COVID-19 International Research Team, Medford, MA, 02155, USA.; Departments of Oncology and Medicine and the Sidney Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA., Koutnik AP; Human Healthspan, Resilience, and Performance, Florida Institute for Human and Machine Cognition, Pensacola, FL, 32502, USA.; Sansum Diabetes Research Institute, Santa Barbara, CA, 93015, USA., Park J; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA.; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, 10065, USA., Clark KB; COVID-19 International Research Team, Medford, MA, 02155, USA.; Cures Within Reach, Chicago, IL, 60602, USA.; Campus and Domain Champions Program, Multi-Tier Assistance, Training, and Computational Help (MATCH) Track, National Science Foundation's Advanced Cyberinfrastructure Coordination Ecosystem: Services and Support (ACCESS), Philadelphia, PA, USA.; Expert Network, Penn Center for Innovation, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Biometrics and Nanotechnology Councils, Institute for Electrical and Electronics Engineers, New York, NY, 10016, USA.; Peace Innovation Institute, The Hague 2511, Netherlands and Stanford University, Palo Alto, 94305, CA, USA., Enguita FJ; COVID-19 International Research Team, Medford, MA, 02155, USA.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisboa, Portugal., Leitão AL; MEtRICs, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal., Das S; COVID-19 International Research Team, Medford, MA, 02155, USA.; Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Mannohar Lohia Hospital, New Delhi, 110001, India., Moraes-Vieira PM; COVID-19 International Research Team, Medford, MA, 02155, USA.; Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC) and Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil., Galeano D; COVID-19 International Research Team, Medford, MA, 02155, USA.; Facultad de Ingeniería, Universidad Nacional de Asunción, San Lorenzo, Paraguay., Mason CE; COVID-19 International Research Team, Medford, MA, 02155, USA.; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA.; New York Genome Center, New York, NY, USA.; The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA., Trovão NS; COVID-19 International Research Team, Medford, MA, 02155, USA.; Fogarty International Center, National Institutes of Health, Bethesda, MD, 20892, USA., Schwartz RE; COVID-19 International Research Team, Medford, MA, 02155, USA.; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Schisler JC; COVID-19 International Research Team, Medford, MA, 02155, USA.; McAllister Heart Institute and Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Coelho-Dos-Reis JGA; COVID-19 International Research Team, Medford, MA, 02155, USA.; Basic and Applied Virology Lab, Department of Microbiology, Institute for Biological Sciences (ICB), Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Wurtele ES; COVID-19 International Research Team, Medford, MA, 02155, USA.; Genetics Program, Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, 90011, USA.; Bioinformatics and Computational Biology Program, Center for Metabolomics, Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, 90011, USA., Beheshti A; COVID-19 International Research Team, Medford, MA, 02155, USA. afshin.beheshti@nasa.gov.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. afshin.beheshti@nasa.gov.; Blue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, Santa Clara, CA, 94035, USA. afshin.beheshti@nasa.gov.

Publikováno v: European journal of human genetics : EJHG [Eur J Hum Genet] 2024 Jan; Vol. 32 (1), pp. 10-20. Date of Electronic Publication: 2023 Nov 08.

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts.

Autor: Guarnieri JW; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Dybas JM; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Fazelinia H; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Kim MS; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA .; Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, South Korea., Frere J; Icahn School of Medicine at Mount Sinai, New York, NY 10023, USA., Zhang Y; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Soto Albrecht Y; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Murdock DG; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Angelin A; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Singh LN; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Weiss SL; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Best SM; COVID-19 International Research Team, Medford, MA 02155, USA .; Rocky Mountain Laboratory, National Institute of Allergy and Infectious Disease, NIH, Hamilton, MT 59840, USA., Lott MT; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Zhang S; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Cope H; University of Nottingham, Nottingham, UK., Zaksas V; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Chicago, Chicago, IL 60615, USA.; Clever Research Lab, Springfield, IL 62704, USA., Saravia-Butler A; COVID-19 International Research Team, Medford, MA 02155, USA .; Logyx, LLC, Mountain View, CA 94043, USA.; NASA Ames Research Center, Moffett Field, CA 94035, USA., Meydan C; COVID-19 International Research Team, Medford, MA 02155, USA .; Weill Cornell Medicine, New York, NY 10065, USA., Foox J; Weill Cornell Medicine, New York, NY 10065, USA., Mozsary C; Weill Cornell Medicine, New York, NY 10065, USA., Bram Y; Weill Cornell Medicine, New York, NY 10065, USA., Kidane Y; COVID-19 International Research Team, Medford, MA 02155, USA .; Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA., Priebe W; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Emmett MR; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Texas Medical Branch, Galveston, TX 77555, USA., Meller R; COVID-19 International Research Team, Medford, MA 02155, USA .; Morehouse School of Medicine, Atlanta, GA 30310, USA., Demharter S; DKAbzu ApS, Copenhagen 2150, Denmark., Stentoft-Hansen V; DKAbzu ApS, Copenhagen 2150, Denmark., Salvatore M; DKAbzu ApS, Copenhagen 2150, Denmark., Galeano D; COVID-19 International Research Team, Medford, MA 02155, USA .; Facultad de Ingeniería, Universidad Nacional de Asunción, San Lorenzo, Central, Paraguay., Enguita FJ; COVID-19 International Research Team, Medford, MA 02155, USA .; Faculdade de Medicina, Universidade de Lisboa, Instituto de Medicina Molecular João Lobo Antunes, 1649-028 Lisboa, Portugal., Grabham P; College of Physicians and Surgeons, Columbia University, New York, NY 19103, USA., Trovao NS; COVID-19 International Research Team, Medford, MA 02155, USA .; Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA., Singh U; COVID-19 International Research Team, Medford, MA 02155, USA .; Iowa State University, Ames, IA 50011, USA., Haltom J; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA .; Iowa State University, Ames, IA 50011, USA., Heise MT; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Moorman NJ; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Baxter VK; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Madden EA; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Taft-Benz SA; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Anderson EJ; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Sanders WA; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dickmander RJ; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Baylin SB; COVID-19 International Research Team, Medford, MA 02155, USA .; Johns Hopkins School of Medicine, Baltimore, MD 21287, USA., Wurtele ES; COVID-19 International Research Team, Medford, MA 02155, USA .; Iowa State University, Ames, IA 50011, USA., Moraes-Vieira PM; COVID-19 International Research Team, Medford, MA 02155, USA .; University of Campinas, Campinas, SP, Brazil., Taylor D; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA ., Mason CE; COVID-19 International Research Team, Medford, MA 02155, USA .; Weill Cornell Medicine, New York, NY 10065, USA.; New York Genome Center, New York, NY 10013, USA., Schisler JC; COVID-19 International Research Team, Medford, MA 02155, USA .; University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Schwartz RE; COVID-19 International Research Team, Medford, MA 02155, USA .; Weill Cornell Medicine, New York, NY 10065, USA., Beheshti A; COVID-19 International Research Team, Medford, MA 02155, USA .; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA., Wallace DC; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; COVID-19 International Research Team, Medford, MA 02155, USA .; Division of Human Genetics, Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Aug 09; Vol. 15 (708), pp. eabq1533. Date of Electronic Publication: 2023 Aug 09.

Phenotypic changes in low-density lipoprotein particles as markers of adverse clinical outcomes in COVID-19.

Autor: Carmo HRP; Cardiology Division, Unicamp Medical School, SP, Brazil., Yoshinaga MY; Department of Biochemistry, Institute of Chemistry, University of São Paulo, SP, Brazil. Electronic address: marcosyukio@gmail.com., Castillo AR; Cardiology Division, Unicamp Medical School, SP, Brazil., Britto Chaves-Filho A; Department of Biochemistry, Institute of Chemistry, University of São Paulo, SP, Brazil., Bonilha I; Cardiology Division, Unicamp Medical School, SP, Brazil., Barreto J; Cardiology Division, Unicamp Medical School, SP, Brazil., Muraro SP; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., de Souza GF; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Davanzo GG; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Perroud MW Jr; Pneumology Division, Unicamp, SP, Brazil., Lukhna K; Division of Cardiology, University of Cape Town, Cape Town, South Africa., Ntsekhe M; Division of Cardiology, University of Cape Town, Cape Town, South Africa., Davidson S; Hatter Cardiovascular Institute, University College London, London, UK., Velloso LA; Internal Medicine Department, Unicamp Medical School, SP, Brazil., Nadruz W; Cardiology Division, Unicamp Medical School, SP, Brazil., Carvalho LSF; Cardiology Division, Unicamp Medical School, SP, Brazil., Sáinz-Jaspeado M; Mercodia AB, Uppsala, Sweden., Farias AS; Laboratory of Neuroimmunomodulation, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil; Hub of Global Health (HGH), University of Campinas, Campinas, SP, Brazil., Proença-Módena JL; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil; Hub of Global Health (HGH), University of Campinas, Campinas, SP, Brazil., Moraes-Vieira PM; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil; Hub of Global Health (HGH), University of Campinas, Campinas, SP, Brazil., Karathanasis SK; Lipoprotein Metabolism Laboratory Translational Vascular Medicine Branch National Heart, Lung and Blood Institute National Institutes of Health, Bethesda, MD, USA., Yellon D; Hatter Cardiovascular Institute, University College London, London, UK., Miyamoto S; Department of Biochemistry, Institute of Chemistry, University of São Paulo, SP, Brazil., Remaley AT; Lipoprotein Metabolism Laboratory Translational Vascular Medicine Branch National Heart, Lung and Blood Institute National Institutes of Health, Bethesda, MD, USA., Sposito AC; Cardiology Division, Unicamp Medical School, SP, Brazil. Electronic address: sposito@unicamp.com.

Publikováno v: Molecular genetics and metabolism [Mol Genet Metab] 2023 Apr; Vol. 138 (4), pp. 107552. Date of Electronic Publication: 2023 Feb 27.