Novel naphthoquinone-1H-1,2,3-triazole hybrids: Design, synthesis and evaluation as inductors of ROS-mediated apoptosis in the MCF-7 cells

Autor: de Souza, Acácio S., Dias, Deborah S., Ribeiro, Ruan C.B., Costa, Dora C.S., de Moraes, Matheus G., Pinho, David R., Masset, Maria E.G., Marins, Laís M., Valle, Sandy P., de Carvalho, Cláudio J.C., de Carvalho, Gustavo S.G., Mello, Angélica Lauria N., Sola-Penna, Mauro, Palmeira-Mello, Marcos V., Conceição, Raissa A., Rodrigues, Carlos R., Souza, Alessandra M.T., Forezi, Luana da S.M., Zancan, Patricia, Ferreira, Vitor F., da Silva, Fernando de C.

Publikováno v: In Bioorganic & Medicinal Chemistry 15 March 2024 102

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A New Strategy for the Synthesis of Nonsymmetrical 3,3’-(Aryl/alkyl-methylene)bis-2-hydroxy-1,4-naphthoquinones and Their Cytotoxic Effects in PC3 Prostate Cancer Cells

Autor: Ribeiro,Ruan Carlos B., Freitas,Paula Priscilla de, Moreira,Caroline S., Moraes,Leonardo G. C. de, Moraes,Matheus G. de, Silva,Fernando de C. da, Rocha,David R., Gimba,Etel R. Pereira, Ferreira,Vitor F.

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 31, Issue: 2, Pages: 288-297, Published: 20 JAN 2020
Journal of the Brazilian Chemical Society v.31 n.2 2020
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

A novel method for the synthesis of nonsymmetrical 3,3’-(aryl/alkyl-methylene)bis-2-hydroxy-1,4-naphthoquinones was developed by using the Mannich adduct of naphthoquinone and the reaction with another moiety of 2-hydroxy-1,4-naphthoquinone. This n

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