The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage

Autor: De Zio D. 1, 2, Bordi M. 1, Tino E.2, Lanzuolo C.3, 4, Ferraro E.2, Mora E.2, Ciccosanti F.5, Fimia G.M.5, Orlando V.3, Cecconi F.1

Publikováno v: Cell death and differentiation 18(3) (2011): 516–52.
info:cnr-pdr/source/autori:De Zio D. 1,2, Bordi M. 1,2, Tino E.2, Lanzuolo C.3,4, Ferraro E.2, Mora E.2, Ciccosanti F.5, Fimia G.M.5, Orlando V.3, Cecconi F.1,2./titolo:The DNA repair complex Ku70%2F86 modulates Apaf1 expression upon DNA damage/doi:/rivista:Cell death and differentiation/anno:2011/pagina_da:516/pagina_a:52/intervallo_pagine:516–52/volume:18(3)

Apaf1 is a key regulator of the mitochondrial intrinsic pathway of apoptosis, as it activates executioner caspases by forming the apoptotic machinery apoptosome. Its genetic regulation and its post-translational modification are crucial under the var

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http://www.cnr.it/prodotto/i/5027