Epigenetic EGFR Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas

Autor: Capdevila, J, Arques, O, Mora, JRH, Matito, J, Caratu, G, Mancuso, FM, Landolfi, S, Barriuso, J, Jimenez-Fonseca, P, Lopez, CL, Garcia-Carbonero, R, Hernando, J, Matos, I, Paolo, N, Hernandez-Losa, J, Esteller, M, Martinez-Cardus, A, Tabernero, J, Vivancos, A, Palmer, HG

Publikováno v: Clinical Cancer Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Universidad de Alicante (UA)
r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)

Purpose: The limited knowledge of the molecular alterations that characterize poorly differentiated neuroendocrine carcinomas has limited the clinical development of targeted agents directed to driver mutations. Here we aim to identify new molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::21b91f35b909391c7cf8d074a0c8eb79
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1223

Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction.

Autor: Monteagudo-Sánchez A; Imprinting and Cancer Group, Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute - IDIBELL, Av. Gran Via de L'Hospotalet 199-203, 08907 L'Hospitalet de Llobregat, Barcelona, Spain., Sánchez-Delgado M; Imprinting and Cancer Group, Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute - IDIBELL, Av. Gran Via de L'Hospotalet 199-203, 08907 L'Hospitalet de Llobregat, Barcelona, Spain., Mora JRH; Imprinting and Cancer Group, Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute - IDIBELL, Av. Gran Via de L'Hospotalet 199-203, 08907 L'Hospitalet de Llobregat, Barcelona, Spain., Santamaría NT; Imprinting and Cancer Group, Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute - IDIBELL, Av. Gran Via de L'Hospotalet 199-203, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.; Leibniz Institute on Aging, Jena, Germany., Gratacós E; Fetal I+D Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine, Hospital Clínic and Hospital Sant Joan de Déu, Barcelona, Spain., Esteller M; Cancer Epigenetics group, Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute - IDIBELL, Gran via, L'Hospitalet de Llobregat, Barcelona, Spain.; Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain.; Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain., de Heredia ML; Human Molecular Genetics group, Genes, disease and Therapy Program, Bellvitge Biomedical Research Institute - IDIBELL, Av. Gran Via de L'Hospitalet 199-203, 08907, L'Hospitalet de Llobregat, Barcelona, Spain., Nunes V; Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain.; Human Molecular Genetics group, Genes, disease and Therapy Program, Bellvitge Biomedical Research Institute - IDIBELL, Av. Gran Via de L'Hospitalet 199-203, 08907, L'Hospitalet de Llobregat, Barcelona, Spain.; Centro de Investigaciòn Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain., Choux C; Université Bourgogne Franche-Comté - INSERM UMR1231, F-21000, Dijon, France., Fauque P; Université Bourgogne Franche-Comté - INSERM UMR1231, F-21000, Dijon, France., de Nanclares GP; (Epi) Genetics Laboratory, BioAraba National Health Institute, Hospital Universitario Araba-Txagorritxu, Vitoria-Gasteiz, Alava, Spain., Anton L; Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, USA., Elovitz MA; Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, USA., Iglesias-Platas I; GReN (Grup de Reçerca en Neonatologia), BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine, Institut de Reçerca Sant Joan de Déu, Barcelona, Spain., Monk D; Imprinting and Cancer Group, Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute - IDIBELL, Av. Gran Via de L'Hospotalet 199-203, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. dmonk@idibell.cat.

Publikováno v: Clinical epigenetics [Clin Epigenetics] 2019 Feb 26; Vol. 11 (1), pp. 35. Date of Electronic Publication: 2019 Feb 26.