Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mor Savyon"'
Autor:
Mor Savyon, Simone Engelender
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
The accumulation and aggregation of α-synuclein are central to Parkinson’s disease (PD), yet the molecular mechanisms responsible for these events are not fully understood. Post-translational modifications of α-synuclein regulate several of its p
Externí odkaz:
https://doaj.org/article/94569cff419e49b18e173c4dbfb846c0
Autor:
Fatimah Abd Elghani, Hazem Safory, Haya Hamza, Mor Savyon, Malik Farhoud, Michal Toren‐Hershoviz, Zagorka Vitic, Kirsten Ebanks, Vered Shani, Sleman Bisharat, Lihi Shaulov, Claude Brodski, Zhiyin Song, Rina Bandopadhyay, Simone Engelender
Publikováno v:
Aging cell. 21(12)
Parkinson's disease (PD) is characterized by degeneration of neurons, particularly dopaminergic neurons in the substantia nigra. PD brains show accumulation of α-synuclein in Lewy bodies and accumulation of dysfunctional mitochondria. However, the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edaec35675c39c755c0247be306df768
https://pubmed.ncbi.nlm.nih.gov/36307912
https://pubmed.ncbi.nlm.nih.gov/36307912
Autor:
Simone Engelender, Mor Savyon
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 12 (2020)
Frontiers in Aging Neuroscience, Vol 12 (2020)
The accumulation and aggregation of α-synuclein are central to Parkinson’s disease (PD), yet the molecular mechanisms responsible for these events are not fully understood. Post-translational modifications of α-synuclein regulate several of its p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab8d55a649b1231fb99abea1bd6d3e4
https://doi.org/10.3389/fnagi.2020.00167
https://doi.org/10.3389/fnagi.2020.00167
Autor:
Raymonde Szargel, Rina Bandopadhyay, Haya Hamza, Vered Shani, Mor Savyon, Ruth Rott, Fatimah Abd Elghani, Simone Engelender
Publikováno v:
Proceedings of the National Academy of Sciences. 114:13176-13181
α-Synuclein accumulation is a pathological hallmark of Parkinson's disease (PD). Ubiquitinated α-synuclein is targeted to proteasomal or lysosomal degradation. Here, we identify SUMOylation as a major mechanism that counteracts ubiquitination by di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cae80ff0bf4570184b59947ef60e1b2
https://doi.org/10.1073/pnas.1704351114
https://doi.org/10.1073/pnas.1704351114
Autor:
Mor Savyon, Fatimah Abd Elghani, Ruth Rott, Kah-Leong Lim, Tsipora Cohen, Rina Bandopadhyay, Ninghan Wang, Raymonde Szargel, Simone Engelender, Vered Shani, Lihi Shaulov, Christopher A. Ross, Hazem Safory, Hui Zhang, Inna Radzishevsky, Haya Hamza
Publikováno v:
Hum Mol Genet
Mutations in LRRK2 cause autosomal dominant and sporadic Parkinson’s disease, but the mechanisms involved in LRRK2 toxicity in PD are yet to be fully understood. We found that LRRK2 translocates to the nucleus by binding to seven in absentia homolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65005dcf0714e9df0168b83894528018
https://pubmed.ncbi.nlm.nih.gov/31626293
https://pubmed.ncbi.nlm.nih.gov/31626293
Autor:
Abd Elghani, Fatimah1 (AUTHOR), Safory, Hazem1 (AUTHOR), Hamza, Haya1 (AUTHOR), Savyon, Mor1 (AUTHOR), Farhoud, Malik1 (AUTHOR), Toren‐Hershoviz, Michal1 (AUTHOR), Vitic, Zagorka2 (AUTHOR), Ebanks, Kirsten3 (AUTHOR), Shani, Vered1 (AUTHOR), Bisharat, Sleman1 (AUTHOR), Shaulov, Lihi1 (AUTHOR), Brodski, Claude2 (AUTHOR), Song, Zhiyin4 (AUTHOR), Bandopadhyay, Rina3 (AUTHOR), Engelender, Simone1 (AUTHOR) simone@technion.ac.il
Publikováno v:
Aging Cell. Dec2022, Vol. 21 Issue 12, p1-15. 15p.
Autor:
Savyon, Mor, Engelender, Simone
Publikováno v:
Frontiers in Aging Neuroscience; 6/25/2020, Vol. 12, p1-16, 16p