Výsledky vyhledávání

Akademický článek

Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness

Autor: Lana Meshnik, Dan Bar-Yaacov, Dana Kasztan, Tali Neiger, Tal Cohen, Mor Kishner, Itay Valenci, Sara Dadon, Christopher J. Klein, Jeffery M. Vance, Yoram Nevo, Stephan Züchner, Ofer Ovadia, Dan Mishmar, Anat Ben-Zvi

Publikováno v: BMC Biology, Vol 20, Iss 1, Pp 1-17 (2022)

Abstract Background Mitochondrial DNA (mtDNA) is present at high copy numbers in animal cells, and though characterized by a single haplotype in each individual due to maternal germline inheritance, deleterious mutations and intact mtDNA molecules fr

Externí odkaz: https://doaj.org/article/b201b8a14eb44511992dfb57115e956e

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Gonadotropin-releasing hormone-like receptor 2 inversely regulates somatic proteostasis and reproduction in Caenorhabditis elegans

Autor: Mor Kishner, Libat Habaz, Lana Meshnik, Tomer Dvir Meidan, Alexandra Polonsky, Anat Ben-Zvi

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

The quality control machinery regulates the cellular proteome to ensure proper protein homeostasis (proteostasis). In Caenorhabditis elegans, quality control networks are downregulated cell-nonautonomously by the gonadal longevity pathway or metaboli

Externí odkaz: https://doaj.org/article/01d00eb026f7484783c90aa2bf69ca96

Zobrazit plný text záznamu

Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions at different rates across generations

Autor: Neiger T, Dan Mishmar, Lana Meshnik, Kasztan D, Tal Cohen, Christopher J. Klein, Anat Ben-Zvi, Yoram Nevo, Sara Dadon, Mor Kishner, Jeffery M. Vance, Dan Bar-Yaacov, Itay Valenci, Stephan Züchner

Deleterious and intact mitochondrial DNA (mtDNA) mutations frequently co-exist (heteroplasmy). Such mutations likely survive and are inherited due to complementation via the intra-cellular mitochondrial network. Hence, we hypothesized that compromise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1a15ec98b7ee1a2fbd13020446ba127
https://doi.org/10.1101/610758

Zobrazit plný text záznamu

Dietary restriction and gonadal signaling differentially regulate post-development quality control functions in Caenorhabditis elegans

Autor: Anat Ben-Zvi, Nufar Shpigel, Mor Kishner, Netta Shemesh

Publikováno v: Aging Cell

Protein homeostasis is remodeled early in Caenorhabditis elegans adulthood, resulting in a sharp decline in folding capacity and reduced ability to cope with chronic and acute stress. Endocrine signals from the reproductive system can ameliorate this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78749d20411f75678afedcc65bf2a960
https://doi.org/10.1111/acel.12891

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání