Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mooseok Kang"'
Autor:
Juhwan Lee, Kyoung Mi Sim, Mooseok Kang, Hyun Ju Oh, Ho Jung Choi, Yeong Eun Kim, Chan-Gi Pack, Kyunggon Kim, Kyung Mo Kim, Seak Hee Oh, Inki Kim, Iksoo Chang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract X-linked inhibitor of apoptosis protein (XIAP) deficiency causes refractory inflammatory bowel disease. The XIAP protein plays a pivotal role in the pro-inflammatory response through the nucleotide-binding oligomerization domain-containing s
Externí odkaz:
https://doaj.org/article/69e1670aa01b4a2d9e85c0349f2a730d
Autor:
Seungjoon Kim, Mooseok Kang, Dongseok Park, Ae-Ree Lee, Heinrich Betz, Jaewon Ko, Iksoo Chang, Ji Won Um
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102037- (2021)
Summary: Gephyrin is critical for the structure, function, and plasticity of inhibitory synapses. Gephyrin mutations have been linked to various neurological disorders; however, systematic analyses of the functional consequences of these mutations ar
Externí odkaz:
https://doaj.org/article/6832200f58e14551b92e9bc5d33a33e3
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007405 (2020)
Understanding the gating mechanism of ion channel proteins is key to understanding the regulation of cell signaling through these channels. Channel opening and closing are regulated by diverse environmental factors that include temperature, electrica
Externí odkaz:
https://doaj.org/article/149f0c205e9e470eb0de41d63e68e9f1
Autor:
Mooseok Kang, Sangyeol Kim, Hyo Jung Kim, Pravesh Shrestha, Ji-hye Yun, Bong-Kwan Phee, Weontae Lee, Hong Gil Nam, Iksoo Chang
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1141-1150 (2018)
Summary: The affinity of transcription factors (TFs) for their target DNA is a critical determinant of gene expression. Whether the DNA-binding domain (DBD) of TFs alone can regulate binding affinity to DNA is an important question for identifying th
Externí odkaz:
https://doaj.org/article/d123dfa960854de89b1b1cbb140b1b72
Autor:
Mooseok Kang, Jaewon Ko, Ae-Ree Lee, Dongseok Park, Iksoo Chang, Heinrich Betz, Ji Won Um, Seungjoon Kim
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102037-(2021)
iScience
iScience
Summary Gephyrin is critical for the structure, function, and plasticity of inhibitory synapses. Gephyrin mutations have been linked to various neurological disorders; however, systematic analyses of the functional consequences of these mutations are
Autor:
Juhwan Lee, Seongjun Park, Mooseok Kang, Iksoo Chang, Ho Joon Im, In-Jeoung Baek, Inki Kim, Hyo-jeong Kang, Kyuyoung Song, Eul Ju Seo, Kyung Mo Kim, Mi Kyoung Ahn, Sojung Park, Suk-Kyun Yang, Chan-Gi Pack, Seak Hee Oh, Young Hoon Sung, Kunsong Lee, Hye Jin Lee
Publikováno v:
Journal of Crohn'scolitis. 15(8)
Background and Aims Mutations in XIAP can lead to the development of treatment-refractory severe paediatric Crohn’s disease [CD], for which haematopoietic stem cell transplantation is the primary therapeutic option. The interpretation of variants o
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007405 (2020)
PLoS Computational Biology
PLoS Computational Biology
Understanding the gating mechanism of ion channel proteins is key to understanding the regulation of cell signaling through these channels. Channel opening and closing are regulated by diverse environmental factors that include temperature, electrica
Autor:
Pravesh Shrestha, Bong Kwan Phee, Mooseok Kang, Iksoo Chang, Weontae Lee, Ji Hye Yun, Hyo Jung Kim, Sangyeol Kim, Hong Gil Nam
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1141-1150 (2018)
Summary: The affinity of transcription factors (TFs) for their target DNA is a critical determinant of gene expression. Whether the DNA-binding domain (DBD) of TFs alone can regulate binding affinity to DNA is an important question for identifying th
Autor:
Sangyeol Kim, Hong Gil Nam, Iksoo Chang, Mooseok Kang, Pravesh Shrestha, Weontae Lee, Ji Hye Yun, Hyo Jung Kim, Bong-Kwan Phee
Publikováno v:
SSRN Electronic Journal.
Affinity of transcription factors(TFs) to their target DNA is a critical determinant in gene expression. TFs are composed of DNA binding domain (DBD) and regulatory domains, intrinsically disordered and/or negatively charged. Asking whether DBD alone
Autor:
Iksoo Chang, Chun Chen Ho, Mooseok Kang, Tai Huang Huang, Yung Lin Hsieh, Hsiu Ming Shih, Mandar T. Naik, Szu Huan Wang, Pei Hsin Liao, Nandita M. Naik
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
The negatively charged amino acid-dependent sumoylation motif (NDSM) carries an additional stretch of acidic residues downstream of the consensus Ψ-K-x-E/D sumoylation motif. We have previously shown that acetylation of the SUMO E2 conjugase enzyme,