Zobrazeno 1 - 10
of 574
pro vyhledávání: '"Moosa, Mohammadi"'
Autor:
Lei Ying, Luyao Wang, Kaiwen Guo, Yushu Hou, Na Li, Shuyi Wang, Xingfeng Liu, Qijin Zhao, Jie Zhou, Longwei Zhao, Jianlou Niu, Chuchu Chen, Lintao Song, Shaocong Hou, Lijuan Kong, Xiaokun Li, Jun Ren, Pingping Li, Moosa Mohammadi, Zhifeng Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Fibroblast growth factors are involved in systemic glucose homeostasis and of interest for developing therapies for type 2 diabetes and associated metabolic diseases. Here the authors identify paracrine FGF4 as an anti-hyperglycemic FGF, which target
Externí odkaz:
https://doaj.org/article/a9437ca24736421b818a2033c329bf9d
Autor:
Alice Domenichini, Ilaria Casari, Peter V. Simpson, Nima Maheshkumar Desai, Lingfeng Chen, Christopher Dustin, Jeanne S. Edmands, Albert van der Vliet, Moosa Mohammadi, Massimiliano Massi, Marco Falasca
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-17 (2020)
Abstract Background Platinum-based anticancer drugs have been at the frontline of cancer therapy for the last 40 years, and are used in more than half of all treatments for different cancer types. However, they are not universally effective, and pati
Externí odkaz:
https://doaj.org/article/c19888559e7c4861b32b1665c49cc331
Autor:
Farnaz Shamsi, Ruidan Xue, Tian Lian Huang, Morten Lundh, Yang Liu, Luiz O. Leiria, Matthew D. Lynes, Elena Kempf, Chih-Hao Wang, Satoru Sugimoto, Pasquale Nigro, Kathrin Landgraf, Tim Schulz, Yiming Li, Brice Emanuelli, Srinivas Kothakota, Lewis T. Williams, Niels Jessen, Steen Bønløkke Pedersen, Yvonne Böttcher, Matthias Blüher, Antje Körner, Laurie J. Goodyear, Moosa Mohammadi, C. Ronald Kahn, Yu-Hua Tseng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is disso
Externí odkaz:
https://doaj.org/article/de377e337a5a402280aaea762fc97cbe
Autor:
Longwei Zhao, Jianlou Niu, Huan Lin, Jing Zhao, Yang Liu, Zihui Song, Congshang Xiang, Xiaojie Wang, Yong Yang, Xiaokun Li, Moosa Mohammadi, Zhifeng Huang
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 462-477 (2019)
Background: The development of a clinically useful fibroblast growth factor 21 (FGF21) hormone has been impeded by its inherent instability and weak FGF receptor (FGFR) binding affinity. There is an urgent need for innovative approaches to overcome t
Externí odkaz:
https://doaj.org/article/aea3be590a704dd39d4715dd9722dfbc
Autor:
Rafiou Agoro, Min Young Park, Carole Le Henaff, Stanislovas Jankauskas, Alina Gaias, Gaozhi Chen, Moosa Mohammadi, Despina Sitara
Publikováno v:
Haematologica, Vol 106, Iss 2 (2020)
Hypoferremia results as an acute phase response to infection and inflammation aiming to reduce iron availability to pathogens. Activation of toll-like receptors (TLRs), the key sensors of the innate immune system, induces hypoferremia mainly through
Externí odkaz:
https://doaj.org/article/0f93508a40b44c7e862596dbf8a579d7
Autor:
Hongbin Sun, Wei Lin, Yu Tang, Hongqing Tu, Ting Chen, Jie Zhou, Dezhong Wang, Qingqing Xu, Jianlou Niu, Wenliya Dong, Sidan Liu, Xinyan Ni, Wen Yang, Yingzheng Zhao, Lei Ying, Jie Zhang, Xiaokun Li, Moosa Mohammadi, Wei L. Shen, Zhifeng Huang
Publikováno v:
Cell Metabolism.
Autor:
Cheng Xu, Andrea Messina, Emmanuel Somm, Hichem Miraoui, Tarja Kinnunen, James Acierno, Nicolas J Niederländer, Justine Bouilly, Andrew A Dwyer, Yisrael Sidis, Daniele Cassatella, Gerasimos P Sykiotis, Richard Quinton, Christian De Geyter, Mirjam Dirlewanger, Valérie Schwitzgebel, Trevor R Cole, Andrew A Toogood, Jeremy MW Kirk, Lacey Plummer, Urs Albrecht, William F Crowley, Moosa Mohammadi, Manuel Tena‐Sempere, Vincent Prevot, Nelly Pitteloud
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 10, Pp 1379-1397 (2017)
Abstract Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic form of isolated gonadotropin‐releasing hormone (GnRH) deficiency caused by mutations in > 30 genes. Fibroblast growth factor receptor 1 (FGFR1) is the most frequently mutate
Externí odkaz:
https://doaj.org/article/7a254787799e445f8c77305b0142a29e
Autor:
Allen Zinkle, Moosa Mohammadi
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Mammalian fibroblast growth factor (FGF) signaling is intricately regulated via selective binding interactions between 18 FGF ligands and four FGF receptors (FGFR1–4), three of which (FGFR1–3) are expressed as either epithelial (“b”) or mesen
Externí odkaz:
https://doaj.org/article/be11a677004c4db7ba70da90af483657
Autor:
Pamela M. Pollock, Moosa Mohammadi, Paul S. Meltzer, Boris C. Bastian, Jeffrey M. Trent, Graham J. Mann, Erica Riedesel, Ursula L. Harper, Pilar Hyder, John A. Curtin, Jinghong Ma, Anna V. Eliseenkova, Laura M. Yudt, Ana Bengston, Candice L. Wellens, Amy V. Curtis, Sara A. Byron, Omar A. Ibrahimi, Huaibin Chen, Michael G. Gartside
Supplementary Data from Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af4aebac59a086a670ecb8c94a476a0
https://doi.org/10.1158/1541-7786.22519251
https://doi.org/10.1158/1541-7786.22519251
Gatekeeper mutations activate FGF receptor tyrosine kinases by destabilizing the autoinhibited state
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Many types of human cancers are being treated with small molecule ATP-competitive inhibitors targeting the kinase domain of receptor tyrosine kinases. Despite initial successful remission, long-term treatment almost inevitably leads to the emergence