Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Moorthy P, Ponnusamy"'
Autor:
Ayoola O. Ogunleye, Neelanjana Gayen, Sanchita Rauth, Saravanakumar Marimuthu, Rama Krishna Nimmakayala, Zahraa W. Alsafwani, Jesse L. Cox, Surinder K. Batra, Moorthy P. Ponnusamy
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Background PAF1/PD2 deregulation contributes to tumorigenesis, drug resistance, and cancer stem cell maintenance in Pancreatic Cancer (PC). Recent studies demonstrate that metabolic reprogramming plays a role in PC progression, but the mecha
Externí odkaz:
https://doaj.org/article/3ef116e6ac1745ca95ccd797415b56f9
Autor:
Pranita Atri, Ashu Shah, Gopalakrishnan Natarajan, Satyanarayana Rachagani, Sanchita Rauth, Koelina Ganguly, Joseph Carmicheal, Dario Ghersi, Jesse L. Cox, Lynette M. Smith, Maneesh Jain, Sushil Kumar, Moorthy P. Ponnusamy, Parthasarathy Seshacharyulu, Surinder K. Batra
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-15 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to limited therapeutic options and expensive/burdensome drug discovery processes. Utilizing genomic-data-driven Connectivity Mapping (CMAP) to identify a drug closer to real-w
Externí odkaz:
https://doaj.org/article/27698b79b7aa49419b969e281158a44b
Autor:
Ashu Shah, Sanjib Chaudhary, Imayavaramban Lakshmanan, Abhijit Aithal, Sophia G. Kisling, Claire Sorrell, Saravanakumar Marimuthu, Shailendra K. Gautam, Sanchita Rauth, Prakash Kshirsagar, Jesse L. Cox, Gopalakrishnan Natarajan, Rakesh Bhatia, Kavita Mallya, Satyanarayana Rachagani, Mohd Wasim Nasser, Apar Kishor Ganti, Ravi Salgia, Sushil Kumar, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-16 (2023)
Abstract Aberrantly expressed onco-mucin 16 (MUC16) and its post-cleavage generated surface tethered carboxy-terminal (MUC16-Cter) domain are strongly associated with poor prognosis and lethality of pancreatic (PC) and non-small cell lung cancer (NSC
Externí odkaz:
https://doaj.org/article/32f677e6e7f342b1a84bc4cad2938d3b
Autor:
Sanjib Chaudhary, Muthamil Iniyan Appadurai, Shailendra Kumar Maurya, Palanisamy Nallasamy, Saravanakumar Marimuthu, Ashu Shah, Pranita Atri, Chirravuri Venkata Ramakanth, Subodh M. Lele, Parthasarathy Seshacharyulu, Moorthy P. Ponnusamy, Mohd W. Nasser, Apar Kishor Ganti, Surinder K. Batra, Imayavaramban Lakshmanan
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Background Triple-negative breast cancer (TNBC) is highly aggressive with an increased metastatic incidence compared to other breast cancer subtypes. However, due to the absence of clinically reliable biomarkers and targeted therapy in TNBC,
Externí odkaz:
https://doaj.org/article/c89f442b49cf48b58554e7cbf76ee1f0
Autor:
Palanisamy Nallasamy, Rama Krishna Nimmakayala, Seema Parte, Abhirup C. Are, Surinder K. Batra, Moorthy P. Ponnusamy
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-25 (2022)
Abstract Cancer divergence has many facets other than being considered a genetic term. It is a tremendous challenge to understand the metastasis and therapy response in cancer biology; however, it postulates the opportunity to explore the possible me
Externí odkaz:
https://doaj.org/article/cd2266c439b147b7b063f2b9b629b687
Autor:
Rama Krishna Nimmakayala, Ayoola O. Ogunleye, Seema Parte, Nivedeta Krishna Kumar, Pratima Raut, Venkatesh Varadharaj, Naveen Kumar Perumal, Palanisamy Nallasamy, Sanchita Rauth, Jesse L. Cox, Subodh M. Lele, Surinder K. Batra, Moorthy P. Ponnusamy
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-12 (2022)
Abstract Acinar-to-ductal metaplasia (ADM) is a precursor lesion of pancreatic ductal adenocarcinoma (PDAC); however, the regulators of the ADM-mediated PDAC development and its targeting are poorly understood. RNA polymerase II-associated factor 1 (
Externí odkaz:
https://doaj.org/article/7a84fef653ec44ccac54817f42b4f6e8
Autor:
Ramakanth Chirravuri-Venkata, Vi Dam, Rama Krishna Nimmakayala, Zahraa Wajih Alsafwani, Namita Bhyravbhatla, Imayavaramban Lakshmanan, Moorthy P. Ponnusamy, Sushil Kumar, Maneesh Jain, Dario Ghersi, Surinder K. Batra
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
MUC16/CA125 is one of the few oldest cancer biomarkers still used in current clinical practice. As mesothelium is an abundant source of MUC16 and a major contributor to stromal heterogeneity in PDAC, we investigated the regulation of MUC16 in tumor a
Externí odkaz:
https://doaj.org/article/67dc0525e46a477a889f4e265643784d
Autor:
Sanchita Rauth, Koelina Ganguly, Pranita Atri, Seema Parte, Rama Krishna Nimmakayala, Venkatesh Varadharaj, Palanisamy Nallasamy, Raghupathy Vengoji, Ayoola O. Ogunleye, Imayavaramban Lakshmanan, Ramakanth Chirravuri, Mika Bessho, Jesse L. Cox, Jason M. Foster, Geoffrey A. Talmon, Tadayoshi Bessho, Apar Kishor Ganti, Surinder K. Batra, Moorthy P. Ponnusamy
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112043- (2023)
Summary: Cisplatin- and gemcitabine-based chemotherapeutics represent a mainstay of cancer therapy for most solid tumors; however, resistance limits their curative potential. Here, we identify RNA polymerase II-associated factor 1 (PAF1) as a common
Externí odkaz:
https://doaj.org/article/54869e1709fb4e06a58c522c9efae474
Autor:
Raghupathy Vengoji, Pranita Atri, Muzafar A. Macha, Parthasarathy Seshacharyulu, Naveenkumar Perumal, Kavita Mallya, Yutong Liu, Lynette M. Smith, Satyanarayana Rachagani, Sidharth Mahapatra, Moorthy P. Ponnusamy, Maneesh Jain, Surinder K. Batra, Nicole Shonka
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)
Abstract Background Glioblastoma (GBM) has a devastating median survival of only one year. Treatment includes resection, radiation therapy, and temozolomide (TMZ); however, the latter increased median survival by only 2.5 months in the pivotal study.
Externí odkaz:
https://doaj.org/article/4e0ce5e978e945f986e962d8700e2ec6
Autor:
Imayavaramban Lakshmanan, Sanjib Chaudhary, Raghupathy Vengoji, Parthasarathy Seshacharyulu, Satyanarayana Rachagani, Joseph Carmicheal, Rahat Jahan, Pranita Atri, Ramakanth Chirravuri‐Venkata, Rohitesh Gupta, Saravanakumar Marimuthu, Naveenkumar Perumal, Sanchita Rauth, Sukhwinder Kaur, Kavita Mallya, Lynette M. Smith, Subodh M. Lele, Moorthy P. Ponnusamy, Mohd W. Nasser, Ravi Salgia, Surinder K. Batra, Apar Kishor Ganti
Publikováno v:
Molecular Oncology, Vol 15, Iss 7, Pp 1866-1881 (2021)
Lung cancer (LC) is the leading cause of cancer‐related mortality. However, the molecular mechanisms associated with the development of metastasis are poorly understood. Understanding the biology of LC metastasis is critical to unveil the molecular
Externí odkaz:
https://doaj.org/article/79cbd717b199455f95a62235380b7911