Wild-type GBA1 increases the α-synuclein tetramer–monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice

Autor: Glajch, Kelly E., Moors, Tim E., Chen, Yi, Bechade, Pascal A., Nam, Alice Y., Rajsombath, Molly M., McCaffery, Thomas D., Dettmer, Ulf, Weihofen, Andreas, Hirst, Warren D., Selkoe, Dennis J., Nuber, Silke

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2021 Aug 01. 118(31), 1-10.

Externí odkaz: https://www.jstor.org/stable/27052727

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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies.

Autor: Moors, Tim E.^1,2 (AUTHOR), Mona, Daniel³ (AUTHOR), Luehe, Stefan⁴ (AUTHOR), Duran-Pacheco, Gonzalo⁵ (AUTHOR), Spycher, Liz³ (AUTHOR), Mundigl, Olaf⁶ (AUTHOR), Kaluza, Klaus⁶ (AUTHOR), Huber, Sylwia⁴ (AUTHOR), Hug, Melanie N.⁴ (AUTHOR), Kremer, Thomas³ (AUTHOR), Ritter, Mirko⁷ (AUTHOR), Dziadek, Sebastian⁵ (AUTHOR), Dernick, Gregor⁴ (AUTHOR), van de Berg, Wilma D. J.¹ (AUTHOR) wdj.vandeberg@amsterdamumc.nl, Britschgi, Markus³ (AUTHOR) markus.britschgi@roche.com

Publikováno v: Acta Neuropathologica Communications. 6/3/2022, Vol. 10 Issue 1, p1-22. 22p.

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Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.

Autor: Ramalingam, Nagendran, Jin, Shan-Xue, Moors, Tim E., Fonseca-Ornelas, Luis, Shimanaka, Kazuma, Lei, Shi, Cam, Hugh P., Watson, Aurelia Hays, Brontesi, Lisa, Ding, Lai, Hacibaloglu, Dinc Yasat, Jiang, Haiyang, Choi, Se Joon, Kanter, Ellen, Liu, Lei, Bartels, Tim, Nuber, Silke, Sulzer, David, Mosharov, Eugene V., Chen, Weisheng V.

Publikováno v: NPJ Parkinson's Disease; 1/16/2023, Vol. 9 Issue 1, p1-15, 15p