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BET inhibition reforms the immune microenvironment and alleviates T cell dysfunction in chronic lymphocytic leukemia.

Autor: Smith AL; Eppley Institute for Research in Cancer and Allied Diseases., Skupa SA; Eppley Institute for Research in Cancer and Allied Diseases., Eiken AP; Eppley Institute for Research in Cancer and Allied Diseases., Reznicek TE; Department of Genetics, Cell Biology and Anatomy., Schmitz E; Eppley Institute for Research in Cancer and Allied Diseases., Williams N; Eppley Institute for Research in Cancer and Allied Diseases., Moore DY; Eppley Institute for Research in Cancer and Allied Diseases., D'Angelo CR; Division of Hematology and Oncology, Department of Internal Medicine, and.; Fred & Pamela Buffett Cancer Center (FPBCC), University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA., Kallam A; Division of Hematology and Oncology, Department of Internal Medicine, and.; Fred & Pamela Buffett Cancer Center (FPBCC), University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA., Lunning MA; Division of Hematology and Oncology, Department of Internal Medicine, and.; Fred & Pamela Buffett Cancer Center (FPBCC), University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA., Bociek RG; Division of Hematology and Oncology, Department of Internal Medicine, and.; Fred & Pamela Buffett Cancer Center (FPBCC), University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA., Vose JM; Division of Hematology and Oncology, Department of Internal Medicine, and.; Fred & Pamela Buffett Cancer Center (FPBCC), University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA., Mohamed E; College of Medicine and College of Graduate Studies, California Northstate University, Elk Grove, California, USA., Mahr AR; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Denton PW; Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, USA., Powell B; Plexxikon Inc., South San Francisco, California, USA., Bollag G; Opna Bio LLC, South San Francisco, California, USA., Rowley MJ; Department of Genetics, Cell Biology and Anatomy., El-Gamal D; Eppley Institute for Research in Cancer and Allied Diseases.; Fred & Pamela Buffett Cancer Center (FPBCC), University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA.

Publikováno v: JCI insight [JCI Insight] 2024 May 22; Vol. 9 (10). Date of Electronic Publication: 2024 May 22.

Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.

Autor: Gilham D; Resverlogix Corp., 300, 4820 Richard Road SW, Calgary, AB T3E 6L1, Canada., Smith AL; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 NE Med Center, BCC 4.12.396, Omaha, NE 68198, USA., Fu L; Resverlogix Corp., 300, 4820 Richard Road SW, Calgary, AB T3E 6L1, Canada., Moore DY; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 NE Med Center, BCC 4.12.396, Omaha, NE 68198, USA., Muralidharan A; Department of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE 68198, USA., Reid SPM; Department of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE 68198, USA., Stotz SC; Resverlogix Corp., 300, 4820 Richard Road SW, Calgary, AB T3E 6L1, Canada., Johansson JO; Resverlogix Corp., 300, 4820 Richard Road SW, Calgary, AB T3E 6L1, Canada., Sweeney M; Resverlogix Corp., 300, 4820 Richard Road SW, Calgary, AB T3E 6L1, Canada., Wong NCW; Resverlogix Corp., 300, 4820 Richard Road SW, Calgary, AB T3E 6L1, Canada., Kulikowski E; Resverlogix Corp., 300, 4820 Richard Road SW, Calgary, AB T3E 6L1, Canada., El-Gamal D; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 NE Med Center, BCC 4.12.396, Omaha, NE 68198, USA.

Publikováno v: Biomedicines [Biomedicines] 2021 Apr 18; Vol. 9 (4). Date of Electronic Publication: 2021 Apr 18.