Severe trauma leads to sustained muscle loss, induced frailty, and distinct temporal changes in myokine and chemokine profiles of older patients.

Autor: Polcz VE; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL. Electronic address: https://www.twitter.com/ValeriePolcz., Barrios EL; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL., Cox MC; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL., Rocha I; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL., Liang M; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, FL., Hawkins RB; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL., Darden D; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL., Ungaro R; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL., Dirain M; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL., Mankowski R; Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine, University of Alabama, Birmingham, AL., Mohr AM; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL., Moore FA; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL., Moldawer LL; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL., Efron PA; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL., Brakenridge SC; Department of Surgery, College of Medicine, University of Washington, Harborview Medical Center, Seattle, WA., Loftus TJ; Department of Surgery, Sepsis and Critical Illness Research Center, College of Medicine, University of Florida, Gainesville, FL. Electronic address: tyler.loftus@surgery.ufl.edu.

Publikováno v: Surgery [Surgery] 2024 Nov; Vol. 176 (5), pp. 1516-1524. Date of Electronic Publication: 2024 Aug 22.

Identification of unique microRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after hemorrhagic shock and multiple injuries in young and old adult mice.

Autor: Darden DB; From the Departments of Surgery and Medicine (D.B.D., J.C.M., J.A.S., B.P.F., L.S.K., D.C.N., A.B., T.J.L., F.A.M., S.C.B., L.L.M., A.M.M., P.A.E.), University of Florida College of Medicine; and Department of Molecular Genetics and Microbiology (M.-C.L., H.V.B.), University of Florida, Gainesville, Florida., Mira JC, Lopez MC, Stortz JA, Fenner BP, Kelly LS, Nacionales DC, Budharaju A, Loftus TJ, Baker HV, Moore FA, Brakenridge SC, Moldawer LL, Mohr AM, Efron PA

Publikováno v: The journal of trauma and acute care surgery [J Trauma Acute Care Surg] 2021 Oct 01; Vol. 91 (4), pp. 692-699.

Chronic Critical Illness in Patients With Sepsis is Associated With Persistent Anemia, Inflammation, and Impaired Functional Outcomes.

Autor: Carmichael ED; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA., Apple CG; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA., Kannan KB; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA., Gardener A; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA., Anton S; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA., Efron PA; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA., Moldawer LL; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA., Moore FA; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA., Brakenridge SC; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA., Mohr AM; Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida Health, Gainesville, FL, USA.

Publikováno v: The American surgeon [Am Surg] 2023 Jun; Vol. 89 (6), pp. 2563-2571. Date of Electronic Publication: 2022 May 20.

Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.

Autor: Ozrazgat-Baslanti T; Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida.; Precision and intelligent Systems in Medicine (Prisma ), University of Florida, Gainesville, Florida., Loftus TJ; Department of Surgery, college of Medicine, University of Florida, Gainesville, Florida., Mohandas R; Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida., Wu Q; Department of Surgery, college of Medicine, University of Florida, Gainesville, Florida., Brakenridge S; Department of Surgery, college of Medicine, University of Florida, Gainesville, Florida., Brumback B; Department of Biostatistics, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, Florida., Efron PA; Department of Surgery, college of Medicine, University of Florida, Gainesville, Florida., Anton S; Department of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, Florida., Moore FA; Department of Surgery, college of Medicine, University of Florida, Gainesville, Florida., Moldawer LL; Department of Surgery, college of Medicine, University of Florida, Gainesville, Florida., Segal MS; Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida., Bihorac A; Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida.; Precision and intelligent Systems in Medicine (Prisma ), University of Florida, Gainesville, Florida.

Publikováno v: Annals of surgery [Ann Surg] 2022 Jun 01; Vol. 275 (6), pp. 1184-1193. Date of Electronic Publication: 2020 Nov 13.

Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.

Autor: Darden DB; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Bacher R; Department of Biostatistics, University of Florida, Gainesville, Florida., Brusko MA; Department of Biomedical Engineering, University of Florida College of Medicine, Gainesville, Florida., Knight P; Department of Mathematics, University of Florida, Gainesville, Florida., Hawkins RB; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Cox MC; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Dirain ML; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Ungaro R; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Nacionales DC; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Rincon JC; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Gauthier ML; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida., Kladde M; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida., Bihorac A; Department of Medicine, University of Florida College of Medicine, Gainesville, Florida., Brusko TM; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida., Moore FA; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Brakenridge SC; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Mohr AM; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Moldawer LL; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Efron PA; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.

Publikováno v: Shock (Augusta, Ga.) [Shock] 2021 May 01; Vol. 55 (5), pp. 587-595.