Výsledky vyhledávání - "Moonsoo M. Jin"

Akademický článek

Low-dose targeted radionuclide therapy synergizes with CAR T cells and enhances tumor response

Autor: Yanping Yang, Yogindra Vedvyas, Yago Alcaina, Ju Y. Son, Irene M. Min, Moonsoo M. Jin

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Ionizing radiation has garnered considerable attention as a combination partner for immunotherapy due to its potential immunostimulatory effects. In contrast to the more commonly used external beam radiation, we explored the feasibility of combining

Externí odkaz: https://doaj.org/article/1ccec8cc7cc44b3797789c2f3d40aca8

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Akademický článek

Inducible expression of interleukin-12 augments the efficacy of affinity-tuned chimeric antigen receptors in murine solid tumor models

Autor: Yanping Yang, Huan Yang, Yago Alcaina, Janusz Puc, Alyssa Birt, Yogindra Vedvyas, Michael Gallagher, Srinija Alla, Maria Cristina Riascos, Jaclyn E. McCloskey, Karrie Du, Juan Gonzalez-Valdivieso, Irene M. Min, Elisa de Stanchina, Matt Britz, Eric von Hofe, Moonsoo M. Jin

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract The limited number of targetable tumor-specific antigens and the immunosuppressive nature of the microenvironment within solid malignancies represent major barriers to the success of chimeric antigen receptor (CAR)-T cell therapies. Here, us

Externí odkaz: https://doaj.org/article/1773c1a113ad431dbfb194f4da0fc107

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Akademický článek

SSTR2 as an anatomical imaging marker and a safety switch to monitor and manage CAR T cell toxicity

Autor: Yago Alcaina, Yanping Yang, Yogindra Vedvyas, Jaclyn E. McCloskey, Moonsoo M. Jin

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract The ability to image adoptively transferred T cells in the body and to eliminate them to avoid toxicity will be vital for chimeric antigen receptor (CAR) T cell therapy, particularly against solid tumors with higher risk of off-tumor toxicit

Externí odkaz: https://doaj.org/article/b4d931c057124558b1311f10901b0857

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Akademický článek

Chimeric Antigen Receptor T Cell Therapy Targeting ICAM-1 in Gastric Cancer

Autor: Minkyu Jung, Yanping Yang, Jaclyn E. McCloskey, Marjan Zaman, Yogindra Vedvyas, Xianglan Zhang, Dessislava Stefanova, Katherine D. Gray, Irene M. Min, Raza Zarnegar, Yoon Young Choi, Jae-Ho Cheong, Sung Hoon Noh, Sun Young Rha, Hyun Cheol Chung, Moonsoo M. Jin

Publikováno v: Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 587-601 (2020)

Cancer therapy utilizing adoptive transfer of chimeric antigen receptor (CAR) T cells has demonstrated remarkable clinical outcomes in hematologic malignancies. However, CAR T cell application to solid tumors has had limited success, partly due to th

Externí odkaz: https://doaj.org/article/2d219804286b4b9eabd7428add107045

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Akademický článek

[18F]Fluoroethyltriazolyl Monocyclam Derivatives as Imaging Probes for the Chemokine Receptor CXCR4

Autor: Alejandro Amor-Coarasa, James M. Kelly, Pradeep K. Singh, Shashikanth Ponnala, Anastasia Nikolopoulou, Clarence Williams, Yogindra Vedvyas, Moonsoo M. Jin, J. David Warren, John W. Babich

Publikováno v: Molecules, Vol 24, Iss 8, p 1612 (2019)

Determining chemokine receptor CXCR4 expression is significant in multiple diseases due to its role in promoting inflammation, cell migration and tumorigenesis. [68Ga]Pentixafor is a promising ligand for imaging CXCR4 expression in multiple tumor typ

Externí odkaz: https://doaj.org/article/5a56847e5c1d40c8832a2599259bda54

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