Return of the Righting Reflex Does Not Portend Recovery of Cognitive Function in Anesthetized Rats.

Autor: Vincent KF; Anesthesia, Critical Care, and Pain Medicine, Massachusetts's General Hospital, Boston, MA, United States.; Harvard Medical School, Boston, MA, United States., Zhang ER; Anesthesia, Critical Care, and Pain Medicine, Massachusetts's General Hospital, Boston, MA, United States., Kato R; Anesthesia, Critical Care, and Pain Medicine, Massachusetts's General Hospital, Boston, MA, United States.; Harvard Medical School, Boston, MA, United States., Cho A; Touro College of Osteopathic Medicine, New York, NY, United States., Moody OA; Anesthesia, Critical Care, and Pain Medicine, Massachusetts's General Hospital, Boston, MA, United States.; Harvard Medical School, Boston, MA, United States., Solt K; Anesthesia, Critical Care, and Pain Medicine, Massachusetts's General Hospital, Boston, MA, United States.; Harvard Medical School, Boston, MA, United States.

Publikováno v: Frontiers in systems neuroscience [Front Syst Neurosci] 2021 Nov 18; Vol. 15, pp. 762096. Date of Electronic Publication: 2021 Nov 18 (Print Publication: 2021).

D-Amphetamine Rapidly Reverses Dexmedetomidine-Induced Unconsciousness in Rats.

Autor: Kato R; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States., Zhang ER; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States., Mallari OG; University of Massachusetts Medical School, Worcester, MA, United States., Moody OA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States., Vincent KF; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States., Melonakos ED; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States., Siegmann MJ; Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States., Nehs CJ; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States., Houle TT; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States., Akeju O; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States., Solt K; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2021 May 18; Vol. 12, pp. 668285. Date of Electronic Publication: 2021 May 18 (Print Publication: 2021).

D-Amphetamine Accelerates Recovery of Consciousness and Respiratory Drive After High-Dose Fentanyl in Rats.

Autor: Moody OA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States., Zhang ER; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States., Arora V; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States., Kato R; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States., Cotten JF; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States., Solt K; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States.; Department of Anaesthesia, Harvard Medical School, Boston, MA, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2020 Nov 12; Vol. 11, pp. 585356. Date of Electronic Publication: 2020 Nov 12 (Print Publication: 2020).

Modulating native GABA A receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death.

Autor: Kallay L; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Keskin H; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Ross A; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Rupji M; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Moody OA; Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA., Wang X; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada., Li G; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA., Ahmed T; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA., Rashid F; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA., Stephen MR; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA., Cottrill KA; Molecular and Systems Pharmacology Graduate Training Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA, USA., Nuckols TA; Molecular and Systems Pharmacology Graduate Training Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, GA, USA., Xu M; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Martinson DE; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Tranghese F; Electrical and Computer Engineering Department, Boston University, Boston, MA, USA., Pei Y; Center for Cancer and Immunology Research, Brain Tumor Institute, Children's National Medical Center, Washington, DC, USA., Cook JM; Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA., Kowalski J; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.; Department of Biostatistics & Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Taylor MD; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, Canada., Jenkins A; Departments of Anesthesiology & Pharmacology, Emory University School of Medicine, Atlanta, GA, USA., Pomeranz Krummel DA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA. pomeranz.krummel@emory.edu.; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA. pomeranz.krummel@emory.edu.; Winship Cancer Institute, Emory University Hospital, 1365C Clifton Road, Suite C5086, Atlanta, GA, USA. pomeranz.krummel@emory.edu., Sengupta S; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA. soma.sengupta@emory.edu.; Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA. soma.sengupta@emory.edu.; Department of Hematology & Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA. soma.sengupta@emory.edu.; Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA. soma.sengupta@emory.edu.; Winship Cancer Institute, Emory University Hospital, 1365C Clifton Road, Suite C5086, Atlanta, GA, USA. soma.sengupta@emory.edu.

Publikováno v: Journal of neuro-oncology [J Neurooncol] 2019 May; Vol. 142 (3), pp. 411-422. Date of Electronic Publication: 2019 Feb 06.

De novo variants in GABRA2 and GABRA5 alter receptor function and contribute to early-onset epilepsy.

Autor: Butler KM; Department of Human Genetics, Emory University, Atlanta, Georgia, 30322, USA.; Genetics and Molecular Biology Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, Georgia, 30322, USA., Moody OA; Departments of Anesthesiology and Pharmacology, Emory University, Atlanta, Georgia, 30322, USA.; Neuroscience Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, Georgia, 30322, USA., Schuler E; Department for Pediatric Metabolic Medicine and Neurology, University Children's Hospital, Heidelberg, 69120, Germany., Coryell J; Departments of Pediatrics and Neurology, School of Medicine, Oregon Health & Sciences University, Portland, Oregon, 97239, USA., Alexander JJ; Department of Human Genetics, Emory University, Atlanta, Georgia, 30322, USA.; EGL Genetics, Tucker, Georgia, 30084, USA., Jenkins A; Departments of Anesthesiology and Pharmacology, Emory University, Atlanta, Georgia, 30322, USA., Escayg A; Department of Human Genetics, Emory University, Atlanta, Georgia, 30322, USA.

Publikováno v: Brain : a journal of neurology [Brain] 2018 Aug 01; Vol. 141 (8), pp. 2392-2405.