Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Moo Je Sung"'
Autor:
Youngah Shin, Moo Je Sung, Monish Jain, Jake Axford, Natalie Dales, Ina Dix, Brian Hurley, Lawrence G. Hamann, Karin Briner, Atwood K. Cheung, John I. Manchester, Donovan N. Chin, Rajeev Sivasankaran
Publikováno v:
Journal of Medicinal Chemistry. 64:4744-4761
Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by low levels of functional survival motor neuron protein (SMN) resulting from a deletion or loss of function mutation of the survival motor neuron 1 (SMN1) gene. Branaplam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb500bf78e4fb0857bfdd9a64443fed
https://doi.org/10.1021/acs.jmedchem.0c02173
https://doi.org/10.1021/acs.jmedchem.0c02173
Publikováno v:
Successful Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23831df4518a41155d161319f9af412a
https://doi.org/10.1002/9783527826872.ch9
https://doi.org/10.1002/9783527826872.ch9
Autor:
Jake, Axford, Moo Je, Sung, John, Manchester, Donovan, Chin, Monish, Jain, Youngah, Shin, Ina, Dix, Lawrence G, Hamann, Atwood K, Cheung, Rajeev, Sivasankaran, Karin, Briner, Natalie A, Dales, Brian, Hurley
Publikováno v:
Journal of medicinal chemistry. 64(8)
Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by low levels of functional survival motor neuron protein (SMN) resulting from a deletion or loss of function mutation of the survival motor neuron 1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13330dc0c7e19f69d4bd3cf1bf193353
https://pubmed.ncbi.nlm.nih.gov/33822618
https://pubmed.ncbi.nlm.nih.gov/33822618
Autor:
Natalie Dales, Monish Jain, Sanchez Carina Cristina, Ryan Kerrigan, Atwood K. Cheung, Cary Fridrich, Donovan N. Chin, Brian Hurley, Keith Hoffmaster, Lin Deng, Ronald Tomlinson, Marc Hild, Rajeev Sivasankaran, Jake Axford, Aleem Fazal, Gary O’Brien, Christopher Towler, Mailin Van Hoosear, Youngah Shin, Dione Kobayashi, Shen Yiping, Lei Shu, William F. Dietrich, Karen S. Chen, Lawrence G. Hamann, Karin Briner, Rebecca Servais, Cheng Song, Emma Cody, Robert Sun, Daniel Curtis, Moo Je Sung, Ying Hou
Publikováno v:
Journal of Medicinal Chemistry. 61:11021-11036
Spinal muscular atrophy (SMA), a rare neuromuscular disorder, is the leading genetic cause of death in infants and toddlers. SMA is caused by the deletion or a loss of function mutation of the survival motor neuron 1 (SMN1) gene. In humans, a second
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a86b835f8a7bec6e7356af0b03dae4
https://doi.org/10.1021/acs.jmedchem.8b01291
https://doi.org/10.1021/acs.jmedchem.8b01291
Autor:
Taeyoung Yoon, Kevin B. Clairmont, Yongjin Gong, Qing Yang, Marlene Juedes, Andrew Tyler, Michael H. Serrano-Wu, Theresa Cosker, Moo Je Sung, Tara L. Mullarkey, Lisha Li, Gary M. Coppola, Alan D. Neubert, Thomas Daniels, Erik C. Rocheford, Renee Commerford, Ying Hou, Ricardo E. Chatelain, Monish Jain, Brian K. Hubbard
Publikováno v:
ACS Medicinal Chemistry Letters. 3:411-415
High DGAT1 expression levels in the small intestine highlight the critical role this enzyme plays in nutrient absorption. Identification of inhibitors which predominantly inhibit DGAT1 in the gut is an attractive drug discovery strategy with anticipa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d7df1bc35c3873046f61a201f435be
https://doi.org/10.1021/ml3000512
https://doi.org/10.1021/ml3000512
Autor:
Christopher Thomas Brain, Kristy Chung, Markus Vögtle, Ming Xu, Yipin Lu, Hong Cheng, James M. Groarke, Marc O'Reilly, Ying Hou, Chen Christine Hiu-Tung, Mei Xu, Steven Kovats, Moo Je Sung, Troy Smith, Sunkyu Kim, G M Trakshel, Young Shin Cho, He Guo, Junqing Shen, Maria Borland, Rajiv Chopra
Publikováno v:
Journal of Medicinal Chemistry. 53:7938-7957
Identification and structure-guided optimization of a series of 4-(pyrazol-4-yl)-pyrimidines as selective CDK4/6 inhibitors is reported herein. Several potency and selectivity determinants were established based on the X-ray crystallographic analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ca1084815aeaf5b1449a83ece0ad7a
https://doi.org/10.1021/jm100571n
https://doi.org/10.1021/jm100571n
Publikováno v:
Organic Letters. 5:2137-2140
[reaction: see text] In connection with the known diyne-ene [2 + 2 + 2] cycloaddition reactions mediated by titanium aryloxides, the ability of titanium alkoxides to promote coupling of a titanacyclopentadiene with an alkene has been assessed for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b271efe024f252836eb53a9d33a348
https://doi.org/10.1021/ol034592c
https://doi.org/10.1021/ol034592c
Publikováno v:
Tetrahedron Letters. 50:5762-5764
A convenient and selective halogenation of 4-(pyrazol-4-yl)-pyrimidines is described herein. This method allows quick access to a diverse set of pyrazolyl-pyrimidine derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::439f460285325e0bdfe93ce195f670ad
https://doi.org/10.1016/j.tetlet.2009.07.151
https://doi.org/10.1016/j.tetlet.2009.07.151
Autor:
Sang Geun An, Min Gyu Kim, Jae Chul Jung, Myung Hwan Park, Goo Yoon, Moo Je Sung, Young Key Choi, Sang Joon Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2077-2080
The synthesis and in vitro activity of cephalosporins with hydroxamic acid at the 7-position are described. Anti-pseudomonal activity of the compound 11a was shown to be comparable to that of ceftazidime. Especially, the compound 11a exhibited good a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de95f9755740b03e39aac3180fce577d
https://doi.org/10.1016/0960-894x(96)00381-2
https://doi.org/10.1016/0960-894x(96)00381-2
Publikováno v:
Journal of the American Chemical Society. 123:11322-11324
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66adf5f1639a5b4f68d09ae0ea3f76b
https://doi.org/10.1021/ja017043f
https://doi.org/10.1021/ja017043f