Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline

Autor: Neel H. Mehta, Liangdong Zhou, Yi Li, Laura Beth McIntire, Anna Nordvig, Tracy Butler, Mony de Leon, Gloria C. Chiang

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Neuroinflammation is believed to be a key process in Alzheimer’s disease (AD) pathogenesis. Recently, the neutrophil-to-lymphocyte (NLR) and lymphocyte-to-monocyte ratios (LMR) have been proposed to be useful peripheral markers of inflamma

Externí odkaz: https://doaj.org/article/2f2e267ff99946808c84242a0cab048c

Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome

Autor: Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Jarek Wegiel, Shuang Yong Ma, Nanbert Zhong, Teresa Wierzba Bobrowicz, Mony de Leon, Florence Lai, Wayne P. Silverman, Thomas Wisniewski

Publikováno v: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-33 (2022)

Abstract The increased life expectancy of individuals with Down syndrome (DS) is associated with increased prevalence of trisomy 21–linked early-onset Alzheimer’s disease (EOAD) and dementia. The aims of this study of 14 brain regions including t

Externí odkaz: https://doaj.org/article/e02fc323c41542f1af71ad39badabda8

Interactive Associations of Neuropsychiatry Inventory-Questionnaire Assessed Sleep Disturbance and Vascular Risk on Alzheimer’s Disease Stage Progression in Clinically Normal Older Adults

Autor: Omonigho M. Bubu, Ellita T. Williams, Ogie Q. Umasabor-Bubu, Sonya S. Kaur, Arlener D. Turner, Judite Blanc, Jaime Ramos Cejudo, Anna E. Mullins, Ankit Parekh, Korey Kam, Zainab T. Osakwe, Ann W. Nguyen, Antoine R. Trammell, Alfred K. Mbah, Mony de Leon, David M. Rapoport, Indu Ayappa, Gbenga Ogedegbe, Girardin Jean-Louis, Arjun V. Masurkar, Andrew W. Varga, Ricardo S. Osorio

Publikováno v: Frontiers in Aging Neuroscience, Vol 13 (2021)

Background: To determine whether sleep disturbance (SD) and vascular-risk interact to promote Alzheimer’s disease (AD) stage-progression in normal, community-dwelling older adults and evaluate their combined risk beyond that of established AD bioma

Externí odkaz: https://doaj.org/article/f3c787090fa54d17b910d9066159cdb1

Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer's disease transgenic mice using magnetic resonance microimaging.

Autor: Youssef Zaim Wadghiri, Jialin Li, Jinhuan Wang, Dung Minh Hoang, Yanjie Sun, Hong Xu, Wai Tsui, Yongsheng Li, Allal Boutajangout, Andrew Wang, Mony de Leon, Thomas Wisniewski

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57097 (2013)

Amyloid plaques are a key pathological hallmark of Alzheimer's disease (AD). The detection of amyloid plaques in the brain is important for the diagnosis of AD, as well as for following potential amyloid targeting therapeutic interventions. Our group

Externí odkaz: https://doaj.org/article/398166d9a3aa40be9541123529f7501f

Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids:Update From the 2022 'ISMRM Imaging Neurofluids Study group' Workshop in Rome

Autor: Nivedita Agarwal, Laura D. Lewis, Lydiane Hirschler, Leonardo Rivera Rivera, Shinji Naganawa, Swati Rane Levendovszky, Geir Ringstad, Marijan Klarica, Joanna Wardlaw, Costantino Iadecola, Cheryl Hawkes, Roxana Octavia Carare, Jack Wells, Erik N.T.P. Bakker, Vartan Kurtcuoglu, Lynne Bilston, Maiken Nedergaard, Yuki Mori, Marcus Stoodley, Noam Alperin, Mony de Leon, Matthias J.P. van Osch

Publikováno v: Agarwal, N, Lewis, L D, Hirschler, L, Rivera, L R, Naganawa, S, Levendovszky, S R, Ringstad, G, Klarica, M, Wardlaw, J, Iadecola, C, Hawkes, C, Carare, R O, Wells, J, Bakker, E N T P, Kurtcuoglu, V, Bilston, L, Nedergaard, M, Mori, Y, Stoodley, M, Alperin, N, de Leon, M & van Osch, M J P 2023, ' Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids : Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome ', Journal of Magnetic Resonance Imaging . https://doi.org/10.1002/jmri.28759

Neurofluids is a term introduced to define all fluids in the brain and spine such as blood, cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily identified the several different fluid environments in the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf451166b08a78ce0da2cf5b300127b4
https://hdl.handle.net/20.500.11820/d96348c7-2a39-4db7-bdde-9dcb37b86e73