Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Montserrat Shelbourne"'
Autor:
Alistair Stewart, Zofia Komsta, Benjamin Alexander Mayes, Adel Moussa, Alexander Yurek-George, Laura Wallis, Andrew J. Tyrrell, Alexander C. Weymouth-Wilson, Montserrat Shelbourne
Publikováno v:
Tetrahedron Letters. 55:6216-6219
Synthesis of a novel 1′,2′-oxetane-uridine bearing a 2′-C-methyl substituent, [1-(1′,3′-O-anhydro-3′-C-methyl-β- d -psicofuranosyl)uracil], is described. Key to its construction was the use of 6-O-(p-toluoyl)-1,2:3,4-di-O-isopropylidene-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d9524b07c5e8bb11991675d007f7483
https://doi.org/10.1016/j.tetlet.2014.09.069
https://doi.org/10.1016/j.tetlet.2014.09.069
Autor:
Gary Nelson, Mandy Watson, Tilly Bingham, Andrew M. Scott, Tom Pesnot, Anthony Huxley, Jen Morton, Montserrat Shelbourne
Publikováno v:
Cancer Research. 79:2751-2751
Somatic mutations in the TP53 gene are one of the most frequent alterations in human cancers. The resulting TP53-deficient cancer cells rely on WEE1 to trigger a G2/M arrest, which allows for DNA repair and survival. Inhibition of WEE1 has therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a360b87a5ca55ded4272dc3cdeb2585
https://doi.org/10.1158/1538-7445.am2019-2751
https://doi.org/10.1158/1538-7445.am2019-2751
Autor:
Bengt Nordén, Tom Brown, Iris Nandhakumar, Montserrat Shelbourne, Claire Hardiman, Simon R. Gerrard
Publikováno v:
ACS Nano. 6:9221-9228
Thermodynamic instability is a problem when assembling and purifying complex DNA nanostructures formed by hybridization alone. To address this issue, we have used photochemical fixation and orthogonal copper-free, ring-strain-promoted, click chemistr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3890341da5a4ae7e50e2f99baa058eff
https://doi.org/10.1021/nn3035759
https://doi.org/10.1021/nn3035759
Publikováno v:
Chemistry - A European Journal. 17:14851-14856
The phosphoramidite monomer of the C-nucleoside 2'-aminoethoxy-2-amino-3-methylpyridine (AE-MAP) has been synthesized for the first time and incorporated into triplex-forming oligonucleotides (TFOs). Ultraviolet melting and DNase I footprinting studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d988eb6ca453ce72dacd236b80b876
https://doi.org/10.1002/chem.201102287
https://doi.org/10.1002/chem.201102287
Autor:
Montserrat Shelbourne, Benjamin Alexander Mayes, Alistair Stewart, Alexander Yurek-George, Alexander C. Weymouth-Wilson, Laura Wallis, Andrew J. Tyrrell, Zofia Komsta, Adel Moussa
Publikováno v:
Organic Letters. 16:4878-4880
The synthesis of the novel 2',3'-cyclopropane nucleoside 3'-deoxy-3'-C-hydroxymethyl-2',3'-methylene-uridine is described. Stereoselective construction of the cyclopropane ring was achieved via Simmons-Smith cyclopropanation of a benzyl protected sil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9e3adbed20db33c60da7683702b74d
https://doi.org/10.1021/ol502383c
https://doi.org/10.1021/ol502383c
Publikováno v:
ChemBioChem; Vol 11
ChemBioChem
ChemBioChem
A combination of six HyBeacon probes has been used in multiplex genetic analysis to analyse mutations in the CFTR gene of PCR-amplified human DNA. Multicolour HyBeacons of this type have great potential in human genetic screening and point-of-care di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1389d416c26d3327a217c14650aa3e75
Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry
Publikováno v:
Chemical Communications; Vol 48
Chemical Communications
Chemical Communications
Two new dibenzocyclooctyne–thymidine monomers were incorporated into oligonucleotides and crosslinked to azide-labelled complementary strands across the DNA grooves. Equivalent reactions were successful using a (bicyclo[6.1.0]nonyne) alkyne. Oligon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e808358b981c00ea0d8e59586dc5265
https://pubmed.ncbi.nlm.nih.gov/22892959
https://pubmed.ncbi.nlm.nih.gov/22892959
Publikováno v:
TETRAHEDRON. 68(3)
A convenient method of oligonucleotide labeling using click chemistry has been developed. A 2′-mesyloxyethyl ribothymidine phosphoramidite monomer was incorporated into DNA at several loci during solid phase oligonucleotide synthesis and converted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5b5bcc8aba61a0002c78783232c4a2
http://ora.ox.ac.uk/objects/uuid:8ea68c56-15a8-41d4-8fdc-d7024d4adee8
http://ora.ox.ac.uk/objects/uuid:8ea68c56-15a8-41d4-8fdc-d7024d4adee8
Publikováno v:
Chemical Communications; Vol 47
Chemical Communications
Chemical Communications
Templated DNA strand ligation by the ring-strain promoted alkyne-azide [3+2] cycloaddition reaction is very fast; with dibenzocyclooctyne, the reaction is essentially complete in 1 min. It is inhibited by the presence of a single mismatched base pair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24b2adb00794a411cf8fefa3139189f
https://doi.org/10.1039/c1cc10743g
https://doi.org/10.1039/c1cc10743g