Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Montserrat Miralpeix"'
Autor:
Javier Milara, Beatriz Ballester, Alfredo de Diego, Marta Calbet, Isabel Ramis, Montserrat Miralpeix, Julio Cortijo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Non-T2 severe asthma and chronic obstructive pulmonary disease (COPD) are airway chronic inflammatory disorders with a poor response to corticosteroids. LAS194046, a novel pan-Janus kinase (JAK) inhibitor, shows inhibitory effects on T2 alle
Externí odkaz:
https://doaj.org/article/b88406e1f3b144f5ba19e15646f52920
Autor:
Thomas Southworth, Sarah Mason, Alan Bell, Isabel Ramis, Marta Calbet, Anna Domenech, Neus Prats, Montserrat Miralpeix, Dave Singh
Publikováno v:
Biomarker Research, Vol 6, Iss 1, Pp 1-8 (2018)
Abstract Background Inhaled allergen challenges are often used to evaluate novel asthma treatments in early phase clinical trials. Current novel therapeutic targets in asthma include phosphoinositide 3-kinases (PI3K) delta and gamma, p38 mitogen-acti
Externí odkaz:
https://doaj.org/article/61ebe37767d74f31aad86d3cf15f3621
Autor:
Javier Milara, Sonia Contreras, Alfredo de Diego, Marta Calbet, Mònica Aparici, Esteban Morcillo, Montserrat Miralpeix, Julio Cortijo
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210188 (2019)
Recent evidence indicates that AZD8999 (LAS190792), a novel muscarinic acetylcholine receptor antagonist and β2-adrenoceptor agonist (MABA) in development for chronic respiratory diseases, induces potent and sustained relaxant effects in human bronc
Externí odkaz:
https://doaj.org/article/81bdef1e1cae445ab600cc01ba807577
Autor:
Adelina Orellana, Vicente García-González, Rosa López, Sonia Pascual-Guiral, Estrella Lozoya, Julia Díaz, Daniel Casals, Antolín Barrena, Stephane Paris, Miriam Andrés, Victor Segarra, Dolors Vilella, Rajneesh Malhotra, Paul Eastwood, Anna Planagumà, Montserrat Miralpeix, Arsenio Nueda
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0189247 (2018)
Thymic stromal lymphopoietin (TSLP) is a cytokine released by human lung epithelium in response to external insult. Considered as a master switch in T helper 2 lymphocyte (Th2) mediated responses, TSLP is believed to play a key role in allergic disea
Externí odkaz:
https://doaj.org/article/c80cf08071ce4fa99740c728ba8e54ad
Autor:
Javier Milara, Beatriz Ballester, Alfredo de Diego, Marta Calbet, Isabel Ramis, Montserrat Miralpeix, Julio Cortijo
Publikováno v:
SCIENTIFIC REPORTS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Non-T2 severe asthma and chronic obstructive pulmonary disease (COPD) are airway chronic inflammatory disorders with a poor response to corticosteroids. LAS194046, a novel pan-Janus kinase (JAK) inhibitor, shows inhibitory effects on T2 allergic lung
Autor:
Silvia Fonquerna, Paul R. Eastwood, Adela Orellana, Jorge De Alba, Elena Calama, Cristina Carreño, Joan Albertí, Isabel Ramis, Ana Andrés, Neus Prats, Elena Gómez, Elena Calaf, Jacob González, M. I. Maldonado, Montserrat Miralpeix, Marta Calbet, Juan J. Perez, J. A. Alonso, Jordi Bach, Estrella Lozoya
Publikováno v:
Journal of Medicinal Chemistry. 62:9045-9060
Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation
Autor:
Jorge De Alba, Carla Carcasona, Jose Luis Montero, Julio Cortijo, Carlos Puig, Jose Luis Ortiz, Dolors Vilella, Israel Ramos, Chris P. Doe, Montserrat Miralpeix, Mònica Aparici, Raquel Otal, Amadeu Gavaldà
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 370:127-136
AZD8871 is a novel muscarinic antagonist and β2-adrenoceptor agonist in development for chronic obstructive pulmonary disease. This study describes the pharmacological profile of AZD8871 in in vitro and in vivo assays. AZD8871 is potent at the human
Autor:
Montse Erra, Jordi Gràcia, Joan Taltavull, Lluís Pagès, Elena Calama, María Domínguez, J.F. Caturla, Sonia Espinosa, F.J. Bernal, M. Carrascal, Mónica Bravo, M. I. Maldonado, Begoña Hernández, M Sabate, Montserrat Miralpeix, Marta Calbet, Stephane Paris, Lehner, M. Mir
Publikováno v:
Journal of Medicinal Chemistry. 61:9551-9567
Oral PI3Kδ inhibitors such as Idelalisib and Duvelisib have shown efficacy as anticancer agents and Idelalisib has been approved for the treatment of three B-cell cancers. However, Idelalisib has a black box warning on its product label regarding th
Autor:
Josep M. Huerta, Montserrat Miralpeix, Sonia Espinosa, Dolors Vilella, Carlos Puig, Israel Ramos, Amadeu Gavaldà, Mònica Aparici, Maria Letosa
Publikováno v:
European Journal of Pharmacology. 819:89-97
This study describes the association rate and residence time of abediterol, a novel long-acting β2-adrenoceptor agonist (LABA) in Phase II development for treatment of asthma and COPD, in comparison with indacaterol, olodaterol, vilanterol and salme
Autor:
Jose Luis Montero, Montserrat Miralpeix, Amadeu Gavaldà, Julio Cortijo, Jose Luis Ortiz, Israel Ramos, Dolors Vilella, Carlos Puig, Carla Carcasona, Mònica Aparici, Chris Doe
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 46:1-10
LAS190792 is a novel muscarinic antagonist and β2-adrenoceptor agonist in development for chronic respiratory diseases. This study investigated the pharmacological profile of LAS190792 in comparison to batefenterol, tiotropium, indacaterol and oloda