Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Montserrat Martín-Sánchez"'
Autor:
Antonio Garcia-Gomez, Tianlu Li, Carlos de la Calle-Fabregat, Javier Rodríguez-Ubreva, Laura Ciudad, Francesc Català-Moll, Gerard Godoy-Tena, Montserrat Martín-Sánchez, Laura San-Segundo, Sandra Muntión, Xabier Morales, Carlos Ortiz-de-Solórzano, Julen Oyarzabal, Edurne San José-Enériz, Manel Esteller, Xabier Agirre, Felipe Prosper, Mercedes Garayoa, Esteban Ballestar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mesenchymal stromal cells (MSCs) have been shown to support multiple myeloma (MM) development. Here, MSCs isolated from the bone marrow of MM patients are shown to have altered DNA methylation patterns and a methyltransferase inhibitor reverts MM-ass
Externí odkaz:
https://doaj.org/article/97c0cd9d38aa419d8042bda6761115e0
Autor:
Esperanza M Algarín, Andrea Díaz-Tejedor, Pedro Mogollón, Susana Hernández-García, Luis A. Corchete, Laura San-Segundo, Montserrat Martín-Sánchez, Lorena González-Méndez, Marie Schoumacher, Sebastien Banquet, Laurence Kraus-Berthier, Ioana Kloos, Alix Derreal, Ensar Halilovic, Heiko Maacke, Norma C. Gutiérrez, María-Victoria Mateos, Teresa Paíno, Mercedes Garayoa, Enrique M. Ocio
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Externí odkaz:
https://doaj.org/article/512f9175196b4277b36f9d7dcf905aba
Autor:
Ana-Alicia López-Iglesias, Ana B. Herrero, Marta Chesi, Laura San-Segundo, Lorena González-Méndez, Susana Hernández-García, Irena Misiewicz-Krzeminska, Dalia Quwaider, Montserrat Martín-Sánchez, Daniel Primo, Teresa Paíno, P. Leif Bergsagel, Thomas Mehrling, Marcos González-Díaz, Jesús F. San-Miguel, María-Victoria Mateos, Norma C. Gutiérrez, Mercedes Garayoa, Enrique M. Ocio
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-14 (2017)
Abstract Background Despite recent advances in the treatment of multiple myeloma (MM), the prognosis of most patients remains poor, and resistance to traditional and new drugs frequently occurs. EDO-S101 is a novel therapeutic agent conceived as the
Externí odkaz:
https://doaj.org/article/bfebf6dd497c42b797a071d86cc0e1d4
Autor:
Esperanza M. Algarín, Dalia Quwaider, Francisco J. Campos-Laborie, Andrea Díaz-Tejedor, Pedro Mogollón, Elena Vuelta, Montserrat Martín-Sánchez, Laura San-Segundo, Lorena González-Méndez, Norma C. Gutiérrez, Ramón García-Sanz, Teresa Paíno, Javier De Las Rivas, Enrique M. Ocio, Mercedes Garayoa
Publikováno v:
Cells, Vol 10, Iss 3, p 559 (2021)
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesenchymal stromal cells (MSCs),
Externí odkaz:
https://doaj.org/article/7bd7f27b907643eda8b4ac2b546d5f0a
Autor:
Susana Hernández-García, Laura San-Segundo, Lorena González-Méndez, Luis A. Corchete, Irena Misiewicz-Krzeminska, Montserrat Martín-Sánchez, Ana-Alicia López-Iglesias, Esperanza Macarena Algarín, Pedro Mogollón, Andrea Díaz-Tejedor, Teresa Paíno, Brian Tunquist, María-Victoria Mateos, Norma C Gutiérrez, Elena Díaz-Rodriguez, Mercedes Garayoa, Enrique M Ocio
Publikováno v:
Haematologica, Vol 102, Iss 12 (2017)
Kinesin spindle protein inhibition is known to be an effective therapeutic approach in several malignancies. Filanesib (ARRY-520), an inhibitor of this protein, has demonstrated activity in heavily pre-treated multiple myeloma patients. The aim of th
Externí odkaz:
https://doaj.org/article/e78ee3f2567c4e699594330a48ccd63b
Autor:
Ana-Alicia López-Iglesias, Lorena González-Méndez, Laura San-Segundo, Ana B. Herrero, Susana Hernández-García, Montserrat Martín-Sánchez, Norma C. Gutiérrez, Teresa Paíno, Pablo Avilés, María-Victoria Mateos, Jesús F. San-Miguel, Mercedes Garayoa, Enrique M. Ocio
Publikováno v:
Haematologica, Vol 102, Iss 1 (2017)
Despite new advances in multiple myeloma treatment and the consequent improvement in overall survival, most patients relapse or become refractory to treatment. This suggests that new molecules and combinations that may further inhibit important survi
Externí odkaz:
https://doaj.org/article/0431cc7d4e214155a1909b6f5466c684
Autor:
Enrique M. Ocio, Mercedes Garayoa, María-Victoria Maetos, Norma C. Gutiérrez, Luis A. Corchete, Carlos Ortiz-de-Solorzano, David Corbacho, Montserrat Martín-Sánchez, Esperanza M. Algarín, Ana-Alicia López-Iglesias, Susana Hernández-García, Laura San-Segundo, Lorena González-Méndez, Antonio Garcia-Gomez, Teresa Paíno
Purpose: PIM kinases are a family of serine/threonine kinases recently proposed as therapeutic targets in oncology. In the present work, we have investigated the effects of the novel pan-PIM kinase inhibitor, PIM447, on myeloma cells and myeloma-asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c4e842dd6ae86666bf855ccba83042
https://doi.org/10.1158/1078-0432.c.6526520.v1
https://doi.org/10.1158/1078-0432.c.6526520.v1
Autor:
Enrique M. Ocio, Mercedes Garayoa, María-Victoria Maetos, Norma C. Gutiérrez, Luis A. Corchete, Carlos Ortiz-de-Solorzano, David Corbacho, Montserrat Martín-Sánchez, Esperanza M. Algarín, Ana-Alicia López-Iglesias, Susana Hernández-García, Laura San-Segundo, Lorena González-Méndez, Antonio Garcia-Gomez, Teresa Paíno
Supplementary Figure 1. Evaluation of apoptosis and cell cycle in MM cell lines after PIM447 treatment. -Supplementary Figure 2. PIM447 very strongly synergizes with different antimyeloma agents in the RPMI-8226 cell line. -Supplementary Figure 3. Ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c679e19e1bf938a3b2b16c8ee51060
https://doi.org/10.1158/1078-0432.22467035
https://doi.org/10.1158/1078-0432.22467035
Autor:
Lorena González-Méndez, Javier De Las Rivas, Elena Vuelta, Norma C. Gutiérrez, Andrea Díaz-Tejedor, Esperanza M Algarín, Pedro Mogollón, Laura San-Segundo, Dalia Quwaider, Montserrat Martín-Sánchez, Teresa Paíno, Ramón García-Sanz, Enrique M. Ocio, Francisco J. Campos-Laborie, Mercedes Garayoa
Publikováno v:
Cells
Volume 10
Issue 3
Cells, Vol 10, Iss 559, p 559 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cells . 2021 Mar 4;10(3):559
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Volume 10
Issue 3
Cells, Vol 10, Iss 559, p 559 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cells . 2021 Mar 4;10(3):559
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
© 2021 by the authors.
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesen
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23def009e1085f10043ec1f555b25c2d
Autor:
Mercedes Garayoa, Norma C. Gutiérrez, Maria-Victoria Mateos, Luis A. Corchete, Enrique M. Ocio, Laura San-Segundo, Susana Hernández-García, Esperanza M Algarín, Montserrat Martín-Sánchez, Pedro Mogollón, Lorena González-Méndez, Teresa Paíno, Andrea Díaz-Tejedor
Publikováno v:
Cancers (Basel) . 2020 Sep 24;12(10):2743
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Cancers
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancers, Vol 12, Iss 2743, p 2743 (2020)
Volume 12
Issue 10
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Cancers
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancers, Vol 12, Iss 2743, p 2743 (2020)
Volume 12
Issue 10
© 2020 by the authors.
[Background]: Proviral Insertion site for Moloney murine leukemia virus (PIM) kinases are overexpressed in hematologic malignancies, including multiple myeloma. Previous preclinical data from our group demonstrated the an
[Background]: Proviral Insertion site for Moloney murine leukemia virus (PIM) kinases are overexpressed in hematologic malignancies, including multiple myeloma. Previous preclinical data from our group demonstrated the an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3704d9a4aa0ea1386471118477b5714
http://hdl.handle.net/10902/21517
http://hdl.handle.net/10902/21517