Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Montserrat Heras"'
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Akademický článek
The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology
Autor: Rita F. Belo, Margarida L. F. Martins, Liana Shvachiy, Tiago Costa-Coelho, Carolina de Almeida-Borlido, João Fonseca-Gomes, Vera Neves, Hugo Vicente Miranda, Tiago F. Outeiro, Joana E. Coelho, Sara Xapelli, Cláudia A. Valente, Montserrat Heras, Eduard Bardaji, Miguel A. R. B. Castanho, Maria José Diógenes, Ana M. Sebastião
Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)
Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer’s disease (AD). In fact, KTP levels were
Externí odkaz: https://doaj.org/article/23add04407fb425ba6cdc74be1ceea14
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3
Antifungal and anti-biofilm activity of designed derivatives from kyotorphin
Autor: Vasanthakumar G. Ramu, Montserrat Heras, Eduard Bardají, Jéssica Diane dos Santos, Miguel A. R. B. Castanho, Katia Conceição, Juliana Campos Junqueira, Vitor Martins de Andrade
Publikováno v: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
© 2019 British Mycological Society. Published by Elsevier Ltd. All rights reserved.
Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous analgesic neuropeptide first isolated from bovine brain in 1979. Previous studies have shown that kyotor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c91600a7af909a05087ff486610e01
https://pubmed.ncbi.nlm.nih.gov/32389294
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4
Improvement of the pharmacological properties of amidated kyotorphin by means of iodination
Autor: Maria Cristina Oliveira, Isa Serrano, Miguel A. R. B. Castanho, Isabel Santos, Juliana Perazzo, Sónia Sá Santos, João D. G. Correia, Isaura Tavares, Eduard Bardají, Marta M. B. Ribeiro, Montserrat Heras, Lurdes Gano
Publikováno v: MedChemComm. 7:906-913
Amidated kyotorphin (L-Tyr-L-Arg-NH2; KTP-NH2) shows analgesic properties following systemic administration. Although KTP-NH2 does not have toxic effects in the liver, its biodistribution is unknown. KTP-NH2 was radioiodinated to evaluate its biologi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05e6d13be733b9476992f4eeaf66d38d
https://doi.org/10.1039/c6md00028b
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5
Synthesis of new unnatural Nα-Fmoc pyrimidin-4-one amino acids: use of the p-benzyloxybenzyloxy group as a pyrimidinone masking group
Autor: Montserrat Heras, Abdelatif ElMarrouni
Publikováno v: © Organic and Biomolecular Chemistry, 2015, vol. 13, núm. 3, p. 851-858
Articles publicats (D-Q)
DUGiDocs – Universitat de Girona
instname
The p-benzyloxybenzyloxy group is used to mask the oxo function of the 4(3H)-pyrimidinone ring in the synthesis of new unnatural amino acids. The synthetic approach is based on an aromatic nucleophilic substitution reaction between 4-[4-(benzyloxy)be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d8649d764573f1aef08bb2fbc1d4d0
https://doi.org/10.1039/c4ob02235a
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6
Correlation between membrane translocation and analgesic efficacy in kyotorphin derivatives
Autor: Isaura Tavares, João M. Freire, Montserrat Heras, Vasanthakumar G. Ramu, Miguel A. R. B. Castanho, Antónia R. T. Pinto, Isa Serrano, Eduard Bardají
Publikováno v: Biopolymers. 104:1-10
Amidated kyotorphin (l-Tyr-l-Arg-NH2; KTP-NH2) causes analgesia when systemically administered. The lipophilic ibuprofen-conjugated derivative of KTP-NH2 has improved analgesic efficacy. However, fast degradation by peptidases impacts negatively in t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7ea1d32bac06728901cf4db9304aa18
https://doi.org/10.1002/bip.22580
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7
Neuropeptide kyotorphin impacts on lipopolysaccharide-induced glucocorticoid-mediated inflammatory response : a molecular link to nociception, neuroprotection, and anti-inflammatory action
Autor: Miguel A. R. B. Castanho, Juliana Perazzo, Montserrat Heras, Mônica Lopes-Ferreira, Carla Lima, Eduard Bardají
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Chemical Neuroscience
© 2017 American Chemical Society
Neuropeptide kyotorphin (KTP) is a potent analgesic if administered directly into the brain. In contrast, KTP-amide (KTP-NH2) is analgesic, neuroprotective, and anti-inflammatory following systemic administratio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0bf0b6c8442d9b48e00b40440f91e7
https://hdl.handle.net/10451/32603
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8
Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance
Autor: Catarina Cunha-Santos, Montserrat Heras, Ana Salomé Veiga, Matteo Porotto, João M. Freire, João Gonçalves, Tiago N. Figueira, Anne Moscona, Miguel A. R. B. Castanho
Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, pp.45647. ⟨10.1038/srep45647⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Scientific Reports, 2017, vol.7, art. núm. 45647
Articles publicats (D-Q)
DUGiDocs – Universitat de Girona
Scientific Reports, 2017, 7, pp.45647. ⟨10.1038/srep45647⟩
© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3978fed9394ac2a64dcd8d6b31116457
https://hdl.handle.net/10451/32602
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9
DEPBT as Coupling Reagent To Avoid Racemization in a Solution-Phase Synthesis of a Kyotorphin Derivative
Autor: Montserrat Heras, Vasanthakumar G. Ramu, Eduard Bardají
Publikováno v: Synthesis. 46:1481-1486
The synthesis of IbKTP-NH2 with reduction of racemization up to no detectable level has been achieved using 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT). Among all coupling systems tested, only DEPBT-mediated amide bond formation be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9b9f8a1a45f32d67831cc60d2c60acd
https://doi.org/10.1055/s-0033-1341068
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10
Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation
Autor: Isa Serrano, Carla Lima, Miguel A. R. B. Castanho, Eduard Bardají, Isaura Tavares, Mônica Lopes-Ferreira, Montserrat Heras, Sónia Sá Santos, Juliana Perazzo, Antónia R. T. Pinto, Katia Conceição
Publikováno v: ACS Chemical Neuroscience
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
© 2016 American Chemical Society
Kyotorphin (KTP) is an endogenous peptide with analgesic properties when administered into the central nervous system (CNS). Its amidated form (l-Tyr-l-Arg-NH2; KTP-NH2) has improved analgesic efficacy after sys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fef5ad01f9f0ae97a0f13aa26e1873
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