Výsledky vyhledávání - "Montserrat Arumi-Uria"

Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2 α

Autor: Rubén Vicente, Alejandra R. Alvarez, Francisco J. Muñoz, Daniela A Gutiérrez, Pol Picón-Pagès, Montserrat Arumi-Uria, Marta Tajes, Gerard ILL-Raga, Silvia Menendez, Francesc X. Guix, Alejandro Barranco-Almohalla, Giulia Crepin

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)

Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity induced by the oligomers and f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b2c2683c4cef1d2bccafc4166a3cf4
http://hdl.handle.net/10261/233934

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Prognostic value of VEGFR2 immunoexpression in glioblastoma

Autor: Sergi Mojal, Gemma Issus, Beatriz Bellosillo, Maria Martinez-Garcia, Joan Gibert, Pilar Navarro, Dolores Naranjo-Hans, Francesc Alameda, Montserrat Arumi-Uria

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Glioblastoma is the most frequent and aggressive primary tumor of the central nervous system. Prognosis is poor, with a median survival of 15 months after diagnosis. Various tumor biomarkers show prognostic value for glioblastomas, including VEGFR2,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22260fc58bacbb79031da9b9b53db939
http://hdl.handle.net/10261/230496

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Defective Cyclin B1 Induction in Trastuzumab-emtansine (T-DM1) Acquired Resistance in HER2-positive Breast Cancer

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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Digital.CSIC. Repositorio Institucional del CSIC
Recercat. Dipósit de la Recerca de Catalunya

[Purpose]: Trastuzumab-emtansine (T-DM1) is a standard treatment in advanced HER2-positive breast cancer. However, resistance inevitably occurs. We aimed to identify mechanisms of acquired T-DM1 resistance. [Experimental Design]: HER2-positive breast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1595623a3f4c504e307149483ac7eb3
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1396

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Vías de señalización intracelular en el carcinoma escamoso infiltrante de cérvix uterino. Identificación de nuevos marcadores pronósticos

Autor: Josep Maria Sole, Montserrat Arumi-Uria, Gemma Mancebo, Laia Garrigos, Belen Lloveras, Ramon Carreras, Joan Albanell, Sergi Serrano, Federico Rojo, Francesc Alameda

Publikováno v: Revista Española de Patología. 47:69-75

Resumen Antecedentes y objetivos Los receptores de tirosincinasa estan frecuentemente activados en los tumores humanos malignos. Esta activacion lleva a las celulas a altos niveles de proliferacion, migracion, desdiferenciacion, diseminacion y resist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e487c35101457db5d5bc377879c8646
https://doi.org/10.1016/j.patol.2013.12.001

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Targeting Epithelial-to-Mesenchymal Transition with Met Inhibitors Reverts Chemoresistance in Small Cell Lung Cancer

Autor: Antonio García de Herreros, Manuel Domine, Silvia Menendez, Montserrat Arumi-Uria, Sandra Zazo, Lara Pijuan, Israel Cañadas, Oriol Arpí, Edurne Arriola, Sergi Mojal, Federico Rojo, Joan Albanell, Marta Salido, Ana Rovira, Álvaro Taus

Publikováno v: Clinical Cancer Research. 20:938-950

Purpose: Met receptor phosphorylation is associated with poor prognosis in human small cell lung cancer (SCLC). The aim of our work was to investigate the effects of hepatocyte growth factor (HGF)/Met–mediated epithelial-to-mesenchymal transition (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3037031b35be75ed9d017d56ce695690
https://doi.org/10.1158/1078-0432.ccr-13-1330

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C-MET as a new therapeutic target for the development of novel anticancer drugs

Autor: Ana Rovira, Edurne Arriola, Federico Rojo, Montserrat Arumi-Uria, Israel Cañadas, Joan Albanell

Publikováno v: Clinical and Translational Oncology. 12:253-260

MET is a tyrosine kinase receptor that, upon binding of its natural ligand, the hepatocyte growth factor (HGF), is phosphorylated and subsequently activates different signalling pathways involved in proliferation, motility, migration and invasion. ME

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb48a44fc0b667067e16c92c73b2974
https://doi.org/10.1007/s12094-010-0501-0

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