Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Montserrat Arrasate"'
Autor:
Didio Alberto Ortiz, Nuria Peregrín, Miguel Valencia, Rodrigo Vinueza-Gavilanes, Elisa Marín-Ordovas, Roberto Ferrero, María Jesús Nicolás, Gloria González-Aseguinolaza, Montserrat Arrasate, Tomás Aragón
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/0766beaa99ca4b3eb0b071dad2693434
Autor:
Rodrigo Vinueza-Gavilanes, Jorge Juan Bravo-González, Leyre Basurco, Chiara Boncristiani, Joaquín Fernández-Irigoyen, Enrique Santamaría, Irene Marcilla, Alberto Pérez-Mediavilla, María Rosario Luquin, Africa Vales, Gloria González-Aseguinolaza, María Soledad Aymerich, Tomás Aragón, Montserrat Arrasate
Publikováno v:
Neurobiology of Disease, Vol 183, Iss , Pp 106166- (2023)
Synucleinopathies are a group of neurodegenerative diseases without effective treatment characterized by the abnormal aggregation of alpha-synuclein (aSyn) protein. Changes in levels or in the amino acid sequence of aSyn (by duplication/triplication
Externí odkaz:
https://doaj.org/article/25360ce393ad40769705ef541732c8f6
Autor:
Rodrigo Vinueza-Gavilanes, Ignacio Íñigo-Marco, Laura Larrea, Marta Lasa, Beatriz Carte, Enrique Santamaría, Joaquín Fernández-Irigoyen, Ricardo Bugallo, Tomás Aragón, Rafael Aldabe, Montserrat Arrasate
Publikováno v:
Neurobiology of Disease, Vol 137, Iss , Pp 104781- (2020)
Alpha-synuclein (aSyn) protein levels are sufficient to drive Parkinson's disease (PD) and other synucleinopathies. Despite the biomedical/therapeutic potential of aSyn protein regulation, little is known about mechanisms that limit/control aSyn leve
Externí odkaz:
https://doaj.org/article/67e0990734b34eb9969a4ddd16bcc80c
Autor:
Estefania Rojo-Bustamante, Ignacio Íñigo-Marco, Miguel Angel Abellanas, Rodrigo Vinueza-Gavilanes, Ana Baltanás, Esther Luquin, Montserrat Arrasate, Maria S. Aymerich
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1198 (2020)
Monoacylglycerol lipase inhibition (MAGL) has emerged as an interesting therapeutic target for neurodegenerative disease treatment due to its ability to modulate the endocannabinoid system and to prevent the production of proinflammatory mediators. T
Externí odkaz:
https://doaj.org/article/061d6bb2eb6d434ab504f70791fd0ccc
Autor:
Leyre Basurco, Miguel Angel Abellanas, Leyre Ayerra, Enrique Conde, Rodrigo Vinueza‐Gavilanes, Esther Luquin, Africa Vales, Amaya Vilas, Patxi San Martin‐Uriz, Ibon Tamayo, Marta M. Alonso, Mikel Hernaez, Gloria Gonzalez‐Aseguinolaza, Pedro Clavero, Elisa Mengual, Montserrat Arrasate, Sandra Hervás‐Stubbs, Maria S. Aymerich
Publikováno v:
Glia. 71:571-587
Inflammation is a common feature in neurodegenerative diseases that contributes to neuronal loss. Previously, we demonstrated that the basal inflammatory tone differed between brain regions and, consequently, the reaction generated to a pro-inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d219188ae752b05d2d9e7b086b917e
https://doi.org/10.1002/glia.24295
https://doi.org/10.1002/glia.24295
Autor:
Montserrat Arrasate, Miguel A. Abellanas, Estefanía Rojo-Bustamante, Esther Luquin, Ignacio Iñigo-Marco, María S. Aymerich, Rodrigo Vinueza-Gavilanes, Ana Baltanás
Publikováno v:
Biomolecules
Biomolecules, Vol 10, Iss 1198, p 1198 (2020)
Volume 10
Issue 8
Biomolecules, Vol 10, Iss 1198, p 1198 (2020)
Volume 10
Issue 8
Monoacylglycerol lipase inhibition (MAGL) has emerged as an interesting therapeutic target for neurodegenerative disease treatment due to its ability to modulate the endocannabinoid system and to prevent the production of proinflammatory mediators. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7058ca67818264fa71251d24d2ab0001
https://pubmed.ncbi.nlm.nih.gov/32824740
https://pubmed.ncbi.nlm.nih.gov/32824740
Autor:
Montserrat Arrasate, Ana Baltanás, Tomás J. Aragón, Estefanía Toledo, Elías Marlin, Rodrigo Vinueza-Gavilanes, Ricardo Bugallo, Laura Larrea, Roberto Ferrero
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 5, Pp 1-16 (2020)
Cell Death and Disease, Vol 11, Iss 5, Pp 1-16 (2020)
Loss of protein folding homeostasis features many of the most prevalent neurodegenerative disorders. As coping mechanism to folding stress within the endoplasmic reticulum (ER), the unfolded protein response (UPR) comprises a set of signaling mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c3d99eedb52eb6043f9d957180bef5
https://doi.org/10.1038/s41419-020-2601-2
https://doi.org/10.1038/s41419-020-2601-2
Autor:
Beatriz Carte, Ignacio Iñigo-Marco, Laura Larrea, Marta Lasa, Montserrat Arrasate, Rodrigo Vinueza-Gavilanes, Enrique Santamaría, Tomás J. Aragón, Ricardo Bugallo, Rafael Aldabe, Joaquín Fernández-Irigoyen
Publikováno v:
Neurobiology of Disease, Vol 137, Iss, Pp 104781-(2020)
Alpha-synuclein (aSyn) protein levels are sufficient to drive Parkinson's disease (PD) and other synucleinopathies. Despite the biomedical/therapeutic potential of aSyn protein regulation, little is known about mechanisms that limit/control aSyn leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbb14036a8821b59622d34ca222ecfc
http://www.sciencedirect.com/science/article/pii/S0969996120300565
http://www.sciencedirect.com/science/article/pii/S0969996120300565
Autor:
Ricardo Bugallo, Ignacio Iñigo-Marco, Iker Zuriguel, Miguel Valencia, Mikel Martínez-Goikoetxea, Montserrat Arrasate, Laura Larrea
Publikováno v:
Proceedings of the National Academy of Sciences. 114
α-Synuclein (aSyn) is the main driver of neurodegenerative diseases known as "synucleinopathies," but the mechanisms underlying this toxicity remain poorly understood. To investigate aSyn toxic mechanisms, we have developed a primary neuronal model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f53f74fdfd41cd8aef6acc1f9809f4
https://doi.org/10.1073/pnas.1703420114
https://doi.org/10.1073/pnas.1703420114
Autor:
Montserrat Arrasate, Andrey S. Tsvetkov, Punita Sharma, D. Michael Ando, Benjamin A. Shaby, Steven Finkbeiner, Sami J. Barmada
Publikováno v:
Nature Chemical Biology. 9:586-592
In polyglutamine (polyQ) diseases, only certain neurons die, despite widespread expression of the offending protein. PolyQ expansion may induce neurodegeneration by impairing proteostasis, but protein aggregation and toxicity tend to confound convent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af11bc4bdd5209e674425f67e929d448
https://doi.org/10.1038/nchembio.1308
https://doi.org/10.1038/nchembio.1308