Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA

Autor: David Albesa-Jové, Zuzana Svetlíková, Montse Tersa, Enea Sancho-Vaello, Ana Carreras-González, Pascal Bonnet, Pedro Arrasate, Ander Eguskiza, Shiva K. Angala, Javier O. Cifuente, Jana Korduláková, Mary Jackson, Katarína Mikušová, Marcelo E. Guerin

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

PatA is a membrane-associated acyltransferase that is essential for the biosynthesis of mycobacterial glycolipids. Here, Albesa-Jovéet al. describe structures of PatA from Mycobacterium smegmatisin complex with acyl donors and show that catalysis oc

Externí odkaz: https://doaj.org/article/345eecca519f4563aed75b57f445943c

Dissecting the structural and chemical determinants of the 'open-to-closed' motion in the mannosyltransferase PimA from Mycobacteria

Autor: Natalia Comino, Alexandre Chenal, Beatriz Trastoy, Montse Tersa, Itxaso Anso, Lena Mäler, David Albesa-Jové, David Giganti, Ane Rodrigo-Unzueta, Jobst Liebau, Cecilia D’Angelo, Saioa Urresti, Mattia Ghirardello, J. Ignacio Delso, Javier O. Cifuente, Pedro Merino, Alberto Marina, Marcelo E. Guerin

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Biochemistry
Biochemistry, 2020, 59 (32), pp.2934-2945. ⟨10.1021/acs.biochem.0c00376⟩
Biochemistry, American Chemical Society, 2020, 59 (32), pp.2934-2945. ⟨10.1021/acs.biochem.0c00376⟩
Zaguán. Repositorio Digital de la Universidad de Zaragoza

The phosphatidyl-myo-inositol mannosyltransferase A (PimA) is an essential peripheral membrane glycosyltransferase that initiates the biosynthetic pathway of phosphatidyl-myo-inositol mannosides (PIMs), key structural elements and virulence factors o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c988513a56fe950e468a525d3ea0f08a
https://ueaeprints.uea.ac.uk/id/eprint/85153/

The Molecular Mechanism of Substrate Recognition and Catalysis of the Membrane Acyltransferase PatA from Mycobacteria

Autor: Montse Tersa, David Albesa-Jové, Martine Gilleron, Beatriz Trastoy, Marcelo E. Guerin, Carme Rovira, Lluís Raich, Jacques Prandi

Publikováno v: ACS Chemical Biology
ACS Chemical Biology, American Chemical Society, 2017, 13 (1), pp.131-140. ⟨10.1021/acschembio.7b00578⟩

Glycolipids play a central role in a variety of important biological processes in all living organisms. PatA is a membrane acyltransferase involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs), key structural elements, and virul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8b36e3e4fc7c7f8a461f5efe44a1f7
https://pubmed.ncbi.nlm.nih.gov/29185694

Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis

Autor: Svetlana Ryabova, Maria Rosalia Pasca, Anthony Vocat, Giorgia Mori, Natalia Comino, Karl-Heinz Altmann, Bernhard Pfieiffer, Elisabeth Mohorko, Stewart T. Cole, Vadim Makarov, Giuseppe Zanoni, Giovanna Riccardi, Elena A. Salina, Ane Rodrigo-Unzueta, Ruben C. Hartkoorn, Saioa Urresti, Laurent R. Chiarelli, Silvia Buroni, Marcelo E. Guerin, Ana Luisa de Jesus Lopes Ribeiro, Rudi Glockshuber, Montse Tersa, David Albesa-Jové

Publikováno v: ACS Chemical Biology, 9 (7)

The emergence of multidrug- and extensively drug-resistant strains of Mycobacterium tuberculosis highlights the need to discover new antitubercular agents. Here we describe the synthesis and characterization of a new series of thienopyrimidine (TP) c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c072fc4d268f5944aadac02f60689710
https://pubmed.ncbi.nlm.nih.gov/24877756