Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency.

Autor: Carmo M; Infection, Immunity, Inflammation and Physiological Medicine Programme, Molecular and Cellular Immunology Section, UCL Institute of Child Health, London, UK., Risma KA; 1] Division of Allergy/Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [2] Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [3] Division of Bone Marrow Transplant and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Arumugam P; 1] Division of Allergy/Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [2] Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [3] Division of Bone Marrow Transplant and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Tiwari S; 1] Division of Allergy/Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [2] Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [3] Division of Bone Marrow Transplant and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Hontz AE; 1] Division of Allergy/Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [2] Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [3] Division of Bone Marrow Transplant and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Montiel-Equihua CA; Infection, Immunity, Inflammation and Physiological Medicine Programme, Molecular and Cellular Immunology Section, UCL Institute of Child Health, London, UK., Alonso-Ferrero ME; Infection, Immunity, Inflammation and Physiological Medicine Programme, Molecular and Cellular Immunology Section, UCL Institute of Child Health, London, UK., Blundell MP; Infection, Immunity, Inflammation and Physiological Medicine Programme, Molecular and Cellular Immunology Section, UCL Institute of Child Health, London, UK., Schambach A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany., Baum C; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany., Malik P; 1] Division of Allergy/Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [2] Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [3] Division of Bone Marrow Transplant and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Thrasher AJ; Infection, Immunity, Inflammation and Physiological Medicine Programme, Molecular and Cellular Immunology Section, UCL Institute of Child Health, London, UK., Jordan MB; 1] Division of Allergy/Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [2] Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA [3] Division of Bone Marrow Transplant and Immune Deficiency, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Gaspar HB; Infection, Immunity, Inflammation and Physiological Medicine Programme, Molecular and Cellular Immunology Section, UCL Institute of Child Health, London, UK.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2015 Apr; Vol. 23 (4), pp. 737-45. Date of Electronic Publication: 2014 Dec 19.

Omission of in vivo T-cell depletion promotes rapid expansion of naïve CD4+ cord blood lymphocytes and restores adaptive immunity within 2 months after unrelated cord blood transplant.

Autor: Chiesa R; Bone Marrow Transplantation Department, Great Ormond Street Hospital, London, UK., Gilmour K, Qasim W, Adams S, Worth AJ, Zhan H, Montiel-Equihua CA, Derniame S, Cale C, Rao K, Hiwarkar P, Hough R, Saudemont A, Fahrenkrog CS, Goulden N, Amrolia PJ, Veys P

Publikováno v: British journal of haematology [Br J Haematol] 2012 Mar; Vol. 156 (5), pp. 656-66. Date of Electronic Publication: 2012 Jan 09.

Development of gene therapy: potential in severe combined immunodeficiency due to adenosine deaminase deficiency.

Autor: Montiel-Equihua CA; Centre for immunodeficiency, Molecular immunology Unit, UCL institute of Child Health, London, UK., Thrasher AJ, Gaspar HB

Publikováno v: Stem cells and cloning : advances and applications [Stem Cells Cloning] 2009 Dec 22; Vol. 3, pp. 1-12. Date of Electronic Publication: 2009 Dec 22.

Delivering genes with human immunodeficiency virus-derived vehicles: still state-of-the-art after 25 years.

Autor: Wolff, Jonas Holst¹ (AUTHOR), Mikkelsen, Jacob Giehm¹ (AUTHOR) giehm@biomed.au.dk

Publikováno v: Journal of Biomedical Science. 10/9/2022, Vol. 29 Issue 1, p1-22. 22p.

Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics.

Autor: Cambien, Béatrice¹ (AUTHOR), Lebrigand, Kevin² (AUTHOR), Baeri, Alberto² (AUTHOR), Nottet, Nicolas² (AUTHOR), Compin, Catherine¹ (AUTHOR), Lamit, Audrey¹ (AUTHOR), Ferraris, Olivier³ (AUTHOR), Peyrefitte, Christophe N.³ (AUTHOR), Magnone, Virginie² (AUTHOR), Henriques, Jérôme¹ (AUTHOR), Zaragosi, Laure-Emmanuelle⁴ (AUTHOR), Giorgetti-Peraldi, Sophie⁵ (AUTHOR), Bost, Frédéric⁵ (AUTHOR), Gautier-Isola, Marine² (AUTHOR), Rezzonico, Roger⁴ (AUTHOR), Barbry, Pascal² (AUTHOR), Barthel, Robert⁶ (AUTHOR), Mari, Bernard² (AUTHOR), Vassaux, Georges⁴ (AUTHOR) vassaux@ipmc.cnrs.fr

Publikováno v: PLoS Pathogens. 10/19/2020, Vol. 16 Issue 10, p1-20. 20p.