Knockdown of swine leukocyte antigen expression in porcine lung transplants enables graft survival without immunosuppression.

Autor: Figueiredo C; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, Germany., Chen-Wacker C; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, Germany., Salman J; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany., Carvalho-Oliveira M; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, Germany., Monthé TS; Department of Cardiothoracic Surgery, Jena University Hospital, 07747 Jena, Germany., Höffler K; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany., Rother T; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, Germany., Hacker K; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany., Valdivia E; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, Germany., Pogozhykh O; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, Germany., Hammer S; Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Sommer W; Department of Cardiac Surgery, University of Kiel, 24105 Kiel, Germany., Yuzefovych Y; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, Germany., Wenzel N; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, Germany., Haverich A; Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, 30625 Hannover, Germany., Warnecke G; Department of Cardiac Surgery, University of Kiel, 24105 Kiel, Germany., Blasczyk R; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, 30625 Hannover, Germany.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Jul 17; Vol. 16 (756), pp. eadi9548. Date of Electronic Publication: 2024 Jul 17.