Trehalose Protects against Superoxide Dismutase 1 Proteinopathy in an Amyotrophic Lateral Sclerosis Model.

Autor: Magalhães RSS; Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-901, Brazil., Monteiro Neto JR; Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-901, Brazil., Ribeiro GD; Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-901, Brazil., Paranhos LH; Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-901, Brazil., Eleutherio ECA; Institute of Chemistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-901, Brazil.

Publikováno v: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2024 Jul 03; Vol. 13 (7). Date of Electronic Publication: 2024 Jul 03.

Glycation modulates superoxide dismutase 1 aggregation and toxicity in models of sporadic amyotrophic lateral sclerosis.

Autor: Monteiro Neto JR; Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Brazil; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany., Ribeiro GD; Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Brazil., Magalhães RSS; Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Brazil., Follmer C; Laboratory of Biological Chemistry of Neurodegenerative Disorders, Department of Physical Chemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Brazil., Outeiro TF; Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, Göttingen, Germany; Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne NE2 4HH, UK; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Göttingen, Germany., Eleutherio ECA; Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Brazil. Electronic address: eliscael@iq.ufrj.br.

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2023 Dec; Vol. 1869 (8), pp. 166835. Date of Electronic Publication: 2023 Aug 07.