Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Monte W. Collins"'
Autor:
Monte W. Collins, Douglas E. Dorman, Gregory A. Stephenson, Larry A. Spangle, Leslie J. Lorenz, John L. Occolowitz, Steven W. Baertschi
Publikováno v:
Journal of Pharmaceutical Sciences. 86:526-539
The aqueous acidic degradation of the oral cephalosporin cefaclor was investigated. A number of degradation products were isolated and characterized. The degradation products can be loosely classified into three categories: thiazole derivatives, pyra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1fed4d0e26accb3768e9876de73dc4
https://doi.org/10.1021/js960427x
https://doi.org/10.1021/js960427x
Isolation and Structure Elucidation of the Major Degradation Products of Cefaclor in the Solid State
Autor:
Monte W. Collins, Larry A. Spangle, Fadia Najjar Bashore, John L. Occolowitz, Steven W. Baertschi, Douglas E. Dorman, Leslie J. Lorenz
Publikováno v:
Journal of Pharmaceutical Sciences. 86:540-549
Cefaclor is a beta-lactam antibiotic that degrades slowly under normal storage conditions to several minor products. To obtain samples large enough to permit structure elucidation, cefaclor was allowed to degrade at 40 degrees C (75% relative humidit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e02564b7590098ddc2c4e778b0b2e8a
https://doi.org/10.1021/js960428p
https://doi.org/10.1021/js960428p
Autor:
Michael J. Skibic, Leslie J. Lorenz, John L. Occolowitz, Steven W. Baertschi, Douglas E. Dorman, K. Wayne Taylor, Larry A. Spangle, John W. Paschal, Monte W. Collins
Publikováno v:
Journal of Pharmaceutical Sciences. 82:1010-1017
The aqueous degradation of the carbacephalosporin loracarbef under moderately acidic conditions (pH range, 2.7-4.3) is described. Structures of a total of 10 compounds isolated by preparative reversed-phase HPLC have been proposed. Five of these 10 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1db3a6848a966ab421227a927f41c27
https://doi.org/10.1002/jps.2600821002
https://doi.org/10.1002/jps.2600821002
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 13(3)
Recently an unknown degradation product of loracarbef (structure 1) was observed at low levels (--0.1%) in samples of the bulk drug substance that had been stored at 30°C for 36 months. Identification of this unknown was desired because of the poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faafa487b75c0e6e4fc791a8740d3a58
https://pubmed.ncbi.nlm.nih.gov/7619894
https://pubmed.ncbi.nlm.nih.gov/7619894
Autor:
Leslie J. Lorenz, John L. Occolowitz, Steven W. Baertschi, Marvin Emanuel Wildfeuer, Monte W. Collins, Douglas E. Dorman, Larry A. Spangle
Publikováno v:
Journal of pharmaceutical sciences. 82(6)
The acidic aqueous degradation of cefaclor, an orally administered cephalosporin antibiotic, has been investigated. The most prominent peak in the high-performance liquid chromatography profile of a degraded solution of cefaclor was isolated by prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de41fae3556b6c3e507dcd352417846e
https://pubmed.ncbi.nlm.nih.gov/8331538
https://pubmed.ncbi.nlm.nih.gov/8331538