Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Monte M Winslow"'
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp 1-13 (2020)
Abstract Metastasis is a major cause of morbidity and mortality in cancer patients. However, the molecular and cellular mechanisms underlying the ability of cancer cells to metastasize remain relatively poorly understood. Among all solid tumors, smal
Externí odkaz:
https://doaj.org/article/e4274c505136492c949d915ee2d01d12
Autor:
Rui Tang, Christopher W Murray, Ian L Linde, Nicholas J Kramer, Zhonglin Lyu, Min K Tsai, Leo C Chen, Hongchen Cai, Aaron D Gitler, Edgar Engleman, Wonjae Lee, Monte M Winslow
Publikováno v:
eLife, Vol 9 (2020)
Cell-cell interactions influence all aspects of development, homeostasis, and disease. In cancer, interactions between cancer cells and stromal cells play a major role in nearly every step of carcinogenesis. Thus, the ability to record cell-cell inte
Externí odkaz:
https://doaj.org/article/13a418d59ffc4122921111ddb10c3638
Autor:
Dian Yang, Fangfei Qu, Hongchen Cai, Chen-Hua Chuang, Jing Shan Lim, Nadine Jahchan, Barbara M Grüner, Christin S Kuo, Christina Kong, Madeleine J Oudin, Monte M Winslow, Julien Sage
Publikováno v:
eLife, Vol 8 (2019)
Metastasis is the main cause of death in cancer patients but remains a poorly understood process. Small cell lung cancer (SCLC) is one of the most lethal and most metastatic cancer types. SCLC cells normally express neuroendocrine and neuronal gene p
Externí odkaz:
https://doaj.org/article/fda050c064b3492b90714973d6d4255b
Autor:
Blair B Madison, Arjun N Jeganathan, Rei Mizuno, Monte M Winslow, Antoni Castells, Miriam Cuatrecasas, Anil K Rustgi
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005408 (2015)
Let-7 miRNAs comprise one of the largest and most highly expressed family of miRNAs among vertebrates, and is critical for promoting differentiation, regulating metabolism, inhibiting cellular proliferation, and repressing carcinogenesis in a variety
Externí odkaz:
https://doaj.org/article/c56a5fd19dc14bc8abca06709ecde3d6
Autor:
Christopher W. Murray, Jennifer J. Brady, Mingqi Han, Hongchen Cai, Min K. Tsai, Sarah E. Pierce, Ran Cheng, Janos Demeter, David M. Feldser, Peter K. Jackson, David B. Shackelford, Monte M. Winslow
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
LKB1 tumour suppressor gene is frequently mutated in lung adenocarcinoma. Here the authors show that in genetically engineered mouse models of lung cancer Lkb1 restoration induces growth arrest and drives neoplastic cells toward a more differentiated
Externí odkaz:
https://doaj.org/article/fac054136b674b659d92c440e9e9e2b2
Publikováno v:
Nature Reviews Cancer. 23:391-407
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ed3388a5cb02a6dcc64c0f10dabc1a8
https://doi.org/10.1038/s41568-023-00568-4
https://doi.org/10.1038/s41568-023-00568-4
Autor:
Rui Tang, Emily G. Shuldiner, Marcus Kelly, Christopher W. Murray, Jess D. Hebert, Laura Andrejka, Min K. Tsai, Nicholas W. Hughes, Mitchell I. Parker, Hongchen Cai, Yao-Cheng Li, Geoffrey M. Wahl, Roland L. Dunbrack, Peter K. Jackson, Dmitri A. Petrov, Monte M. Winslow
Publikováno v:
Nature Cell Biology. 25:159-169
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d57cd5248d3f14dde94a8638efa11d0
https://doi.org/10.1038/s41556-022-01049-w
https://doi.org/10.1038/s41556-022-01049-w
Autor:
Shin-Heng Chiou, Madeleine Dorsch, Eva Kusch, Santiago Naranjo, Margaret M. Kozak, Albert C. Koong, Monte M. Winslow, Barbara M. Grüner
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Expression of the chromatin-associated protein HMGA2 correlates with progression, metastasis and therapy resistance in pancreatic ductal adenocarcinoma (PDAC). Hmga2 has also been identified as a marker of a transient subpopulation of PDAC c
Externí odkaz:
https://doaj.org/article/b72834b1a36a49d0bfd2fb6d72fac298
Autor:
Ian P. Winters, Shin-Heng Chiou, Nicole K. Paulk, Christopher D. McFarland, Pranav V. Lalgudi, Rosanna K. Ma, Leszek Lisowski, Andrew J. Connolly, Dmitri A. Petrov, Mark A. Kay, Monte M. Winslow
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Genome editing technologies enable the rapid interrogation of genetic alterations. Here, the authors present a CRISPR/Cas9-based platform to simultaneously investigate multiple activating point mutations in de novo cancers in mice; and generate panel
Externí odkaz:
https://doaj.org/article/ec34a2e663bb4e9aa7d634750cb16aee
Autor:
Monte M. Winslow, Eric L. Snyder, Ian P. Winters, Rosanna K. Ma, Chen-Hua Chuang, Deborah R. Caswell
SELENBP1 expression correlates with NKX2-1 and NKX2-1 target gene expression in human lung adenocarcinoma, and is identified as a potential direct target of Nkx2-1 using an Nkx2-1 ChIP-seq dataset from a mouse model of lung adenocarcinoma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e9c6e27154adf0d8e73e7070cb6689
https://doi.org/10.1158/1541-7786.22511236
https://doi.org/10.1158/1541-7786.22511236
