Výsledky vyhledávání - "Monte J. Radeke"

Akademický článek

An in vitro model of chronic wounding and its implication for age-related macular degeneration.

Autor: Lindsay J Bailey-Steinitz, Ying-Hsuan Shih, Monte J Radeke, Pete J Coffey

Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0236298 (2020)

Degeneration of the retinal pigment epithelium (RPE) plays a central role in age-related macular degeneration (AMD). Throughout life, RPE cells are challenged by a variety of cytotoxic stressors, some of which are cumulative with age and may ultimate

Externí odkaz: https://doaj.org/article/05329caeb9f74de688dce88f7163e518

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Integrated single-cell sequencing reveals principles of epigenetic regulation of human gastrulation and germ cell development in a 3D organoid model

Autor: Alex Chialastri, Eyal Karzbrun, Aimal H. Khankhel, Monte J. Radeke, Sebastian J. Streichan, Siddharth S. Dey

The emergence of different cell types and the role of the epigenome in regulating transcription is a key yet understudied event during human gastrulation. Investigating these questions remain infeasible due to the lack of availability of embryos at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a56994434e677e4479d56a21f117d0fe
https://doi.org/10.1101/2022.02.10.479957

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An in vitro model of chronic wounding and its implication for age-related macular degeneration

Autor: Peter J. Coffey, Ying-Hsuan Shih, Monte J. Radeke, Lindsay Johanna Bailey-Steinitz

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0236298 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9986bcf2e5031eb632b31745c1d9529
http://europepmc.org/articles/PMC7377501

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Akademický článek

Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology.

Autor: Gyungah Jun, Michael Nicolaou, Margaux A Morrison, Jacqueline Buros, Denise J Morgan, Monte J Radeke, Yoshihiro Yonekawa, Evangelia E Tsironi, Maria G Kotoula, Fani Zacharaki, Nissa Mollema, Yang Yuan, Joan W Miller, Neena B Haider, Gregory S Hageman, Ivana K Kim, Debra A Schaumberg, Lindsay A Farrer, Margaret M DeAngelis

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25775 (2011)

ROBO1 is a strong candidate gene for age-related macular degeneration (AMD) based upon its location under a linkage peak on chromosome 3p12, its expression pattern, and its purported function in a pathway that includes RORA, a gene previously associa

Externí odkaz: https://doaj.org/article/5b24c36b3c674577954ae556c79de706

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Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration

Autor: Monte J. Radeke, T. Michael Redmond, William Samuel, Silvia C. Finnemann, Marcia Lloyd, Jane Hu, Cynthia Jaworski, Sze Yin Ng, Zhichun Jiang, Tamara L. Lenis, Dean Bok, Roxana A. Radu, Shanta Sarfare, Nicholas J. Esposito, Gabriel H. Travis

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 47
Proceedings of the National Academy of Sciences of the United States of America

Significance Recessive Stargardt macular degeneration (STGD1) and a subset of cone–rod dystrophies are caused by mutations in the Abca4 gene. The ABCA4 protein is a flippase in photoreceptor cells that helps eliminate retinaldehyde, a toxic photopr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8251b92cb707be43ecb2aa9d9aa30fb7
https://escholarship.org/uc/item/22h745hj

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Array-based Discovery of Aptamer Pairs

Autor: Monte J. Radeke, Jeff Nie, H. Tom Soh, James A. Thomson, Seung Soo Oh, Peter J. Coffey, Michael Eisenstein, Minseon Cho, Ron Stewart

Publikováno v: Analytical Chemistry

Affinity reagent pairs that recognize distinct epitopes on a target protein can greatly improve the sensitivity and specificity of molecular detection. Importantly, such pairs can be conjugated to generate reagents that achieve two-site “bidentate�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45dc395fec919abee3c971ac7b06367
https://doi.org/10.1021/ac504076k

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Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: Characterization, ethnic distribution and evolutionary implications

Autor: Bert Gold, Karen M. Gehrs, Gregory S. Hageman, Joanna E. Merriam, David J. Kavanagh, John P. Atkinson, Julie Bergeron, Lincoln V. Johnson, Lisa S. Hancox, Seppo Meri, Michael Dean, Andrew J Taiber, Monte J. Radeke, Don H. Anderson, Rando Allikmets, Jana Zernant, Anna Richards

Publikováno v: Annals of medicine. 38(8)

Variants in the complement factor H gene (CFH) are associated with age-related macular degeneration (AMD). CFH and five CFH-related genes (CFHR1-5) lie within the regulators of complement activation (RCA) locus on chromosome 1q32. Aims and Methods. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2998d0fdee0f06d80132a54a060feea
https://pubmed.ncbi.nlm.nih.gov/28950782

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Restoration of Mesenchymal RPE by Transcription Factor-Mediated Reprogramming

Autor: Ying-Hsuan Shih, Carolyn M. Radeke, Peter J. Coffey, Monte J. Radeke

Publikováno v: Investigative ophthalmologyvisual science. 58(1)

Purpose Transforming growth factor β-mediated epithelial-to-mesenchymal transition (EMT) is a major component of the wound healing response and a negative determinant of retinal pigment epithelium (RPE) differentiation. We have shown previously that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1618592d984bcd58a1c526129dadc07
https://pubmed.ncbi.nlm.nih.gov/28118667

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Measles Virus C Protein Impairs Production of Defective Copyback Double-Stranded Viral RNA and Activation of Protein Kinase R

Autor: Charles E. Samuel, Roberto Cattaneo, Monte J. Radeke, Christian K. Pfaller

Publikováno v: Journal of virology, vol 88, iss 1

Measles virus (MV) lacking expression of C protein (C KO ) is a potent activator of the double-stranded RNA (dsRNA)-dependent protein kinase (PKR), whereas the isogenic parental virus expressing C protein is not. Here, we demonstrate that significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78034c11bfab6bf00104d6d461370a1e
https://doi.org/10.1128/jvi.02572-13

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