Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Montasir Elahi"'
Autor:
Ahmed Imtiaz, Shotaro Shimonaka, Mohammad Nasir Uddin, Montasir Elahi, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori, Yumiko Motoi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
The efficacy of current treatments is still insufficient for Alzheimer’s disease (AD), the most common cause of Dementia. Out of the two pathological hallmarks of AD amyloid-β plaques and neurofibrillary tangles, comprising of tau protein, tau pat
Externí odkaz:
https://doaj.org/article/160579159a284f1596db2265a64b6963
Autor:
Yumiko Motoi, Nobutaka Hattori, Montasir Elahi, Shotaro Shimonaka, Masashi Takanashi, Yuzuru Imai, Hiroyuki Hioki, Yoko Ishida, Koichi Ishiguro
Publikováno v:
Human Molecular Genetics
Type 2 diabetes mellitus (T2DM) has long been considered a risk factor for Alzheimer’s disease (AD). However, the molecular links between T2DM and AD remain obscure. Here, we reported that serum-/glucocorticoid-regulated kinase 1 (SGK1) is activate
Autor:
Masato Hasegawa, Shin-Ei Matsumoto, Koichi Ishiguro, Montasir Elahi, Yumiko Motoi, Shotaro Shimonaka, Nobutaka Hattori
Publikováno v:
J Biol Chem
In tauopathies, tau forms pathogenic fibrils with distinct conformations (termed “tau strains”) and acts as an aggregation “seed” templating the conversion of normal tau into isomorphic fibrils. Previous research showed that the aggregation c
Autor:
Wei-Bin Shen, Montasir Elahi, James Logue, Penghua Yang, Lauren Baracco, E. Albert Reece, Bingbing Wang, Ling Li, Thomas G Blanchard, Zhe Han, Robert A Rissman, Matthew B Frieman, Peixin Yang
Publikováno v:
bioRxiv
The neurotropism of SARS-CoV-2 and the phenotypes of infected neurons are still in debate. Long COVID manifests with “brain diseases” and the cause of these brain dysfunction is mysterious. Here, we analyze 34 age- and underlying disease-matched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bb2f34d398b63b991560be018f5f9c
https://doi.org/10.1101/2022.01.31.478476
https://doi.org/10.1101/2022.01.31.478476
Autor:
Iwao Hasegawa, Masato Hasegawa, Yuanzhe Li, Masashi Takanashi, Hiroyo Yoshino, Manabu Funayama, Kei-Ichi Ishikawa, Montasir Elahi, Kazuko Hasegawa, Wado Akamatsu, Aya Ikeda, Yuzuru Imai, Nobutaka Hattori, Akihiro Yamaguchi, Nana Izawa, Kahori Shiba-Fukushima, Kenya Nishioka, Risa Nonaka, Hideyuki Okano, Hidemoto Saiki, Akio Mori, Masayo Morita, Tsuyoshi Inoshita, Hongrui Meng, Ayami Okuzumi
Publikováno v:
Human Molecular Genetics. 28:3895-3911
Mutations in CHCHD2 are linked to a familial, autosomal dominant form of Parkinson’s disease (PD). The gene product may regulate mitochondrial respiratory function. However, whether mitochondrial dysfunction induced by CHCHD2 mutations further yiel
Autor:
Tetsuo Hayashi, Yumiko Motoi, Montasir Elahi, Nobutaka Hattori, Koichi Ishiguro, Shin-Ei Matsumoto, Shotaro Shimonaka, Masashi Takanashi
Publikováno v:
Journal of Alzheimer's disease : JAD. 79(4)
Background: Human tauopathy brain injections into the mouse brain induce the development of tau aggregates, which spread to functionally connected brain regions; however, the features of this neurotoxicity remain unclear. One reason may be short obse
Autor:
Montasir Elahi, Shotaro Shimonaka, Yumiko Motoi, Nobutaka Hattori, Mohammad Nasir Uddin, Koichi Ishiguro, Soichiro Kakuta
Publikováno v:
Biochemical and biophysical research communications. 543
Different conformational strains of tau have been implicated in the clinicopathological heterogeneity of tauopathies. In this study, we hypothesized that distinct strains are degraded in a different manner. Lithium, a drug for bipolar disorder, had p
Autor:
Yumiko Motoi, Mohammad Nasir Uddin, Nobutaka Hattori, Shotaro Shimonaka, Soichiro Kakuta, Montasir Elahi, Koichi Ishiguro
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Shin-Ei Matsumoto, Yumiko Motoi, Montasir Elahi, Masato Hasegawa, Shotaro Shimonaka, Nobutaka Hattori, Koichi Ishiguro
Publikováno v:
Alzheimer's & Dementia. 16