Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Montana F. Reilly"'
Autor:
Mark R. Sullivan, Daniel Rosenberg, Ahmed Ali, Jennifer Roth, Caroline A. Lewis, Tenzin Kunchok, Matthew G. Rees, Lena Joesch-Cohen, Matthew G. Vander Heiden, Alicia M. Darnell, Montana F. Reilly
Publikováno v:
Nat Metab
Folate metabolism can be an effective target for cancer treatment. However, standard cell culture conditions utilize folic acid, a non-physiological folate source for most tissues. We find that the enzyme that couples folate and methionine metabolic
Autor:
Emily A Dennstedt, Anna A. Nguyen, Alexander Muir, Mark R. Sullivan, Sharanya Sivanand, Alicia M. Darnell, Katherine R. Mattaini, Marcus Bosenberg, Katrina Meeth, Caroline A. Lewis, Matthew G. Vander Heiden, Montana F. Reilly
Publikováno v:
Cell Metab
PMC
PMC
Tumors exhibit altered metabolism compared to normal tissues. Many cancers upregulate expression of serine synthesis pathway enzymes, and some tumors exhibit copy-number gain of the gene encoding the first enzyme in the pathway, phosphoglycerate dehy