Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

Autor: Pons, D., Trompet, S., Craen, A.J.M. de, Thijssen, P.E., Quax, P.H.A., Vries, M.R. de, Wierda, R.J., Elsen, P.J. van den, Monraats, P.S., Ewing, M.M., Heijmans, B.T., Slagboom, P.E., Zwinderman, A.H., Doevendans, P.A.F.M., Tio, R.A., Winter, R.J. de, Maat, M.P.M. de, Iakoubova, O.A., Sattar, N., Shepherd, J., Westendorp, R.G.J., Jukema, J.W., PROSPER Study Grp, WOSCOPS Study Grp, GENDER Study Grp

Publikováno v: Heart (British Cardiac Society), 97(2), 143-150. BMJ Publishing Group
Pons, D, Trompet, S, Craen, A J M, Thijssen, P E, Quax, P H A, de Vries, M R, Wierda, R J, van den Elsen, P J, Monraats, P S, Ewing, M M, Heijmans, B T, Slagboom, P E, Zwinderman, A H, Doevendans, P A F M, Tio, R A, de Winter, R J, de Maat, M P M, Lakoubova, O A, Sattar, N, Sheperd, J, Westendorp, R G J & Jukema, J W 2011, ' Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies ', Heart, vol. 97, no. 2, pp. 143-150 . https://doi.org/10.1136/hrt.2010.199927
Heart
Heart, 97(2), 143-150. BMJ Publishing Group
Heart, 97(2), 143-150. BMJ PUBLISHING GROUP
Heart, 97(2), 143-150

Aims This study was designed to investigate the counterbalancing influence of genetic variation in the promoter of the gene encoding P300/CBP associated factor (PCAF), a lysine acetyltransferase (KAT), on coronary heart disease (CHD) and mortality.Me

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The effect of interleukin-10 knock-out and overexpression on neointima formation in hypercholesterolemic APOE*3-Leiden mice

Autor: Eefting, D., Schepers, A., Vries, M.R. de, Pires, N.M.M., Grimbergen, J.M., Lagerweij, T., Nagelkerken, L.M., Monraats, P.S., Jukema, J.W., Bockel, J.H. van, Quax, P.H.A.

Publikováno v: Atherosclerosis, 2, 193, 335-342

Objective: Inflammatory factors are thought to play a regulatory role in restenosis. Interleukin-10 (IL10) is an important anti-inflammatory cytokine with anti-atherogenic potentials. The aim of this study was to assess the effects of IL10 modulation

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Tumor necrosis factor-α plays an important role in restenosis development

Autor: Monraats, P.S., Pires, N.M.M., Schepers, A., Agema, W.R.P., Boesten, L.S.M., Vries, M.R. de, Zwinderman, A.H., Maat, M.P.M. de, Doevendans, P.A.F.M., Winter, R.J. de, Tio, R.A., Waltenberger, J., Hart, L.M. 't, Frants, R.R., Quax, P.H.A., Vlijmen, B.J.M. van, Havekes, L.M., Laarse, A. van der, Wall, E.E. van der, Jukema, J.W.

Publikováno v: FASEB Journal, 14, 19, 1998-2004

Genetic factors appear to be important in the restenotic process after percutaneous coronary intervention (PCI), as well as in inflammation, a pivotal factor in restenosis. TNFα, a key regulator of inflammatory responses, may exert critical influenc

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Current PTCA practice and clinical outcomes in the Netherlands: The real world in the pre-drug-eluting stent era

Autor: Agema, W.R.P., Monraats, P.S., Zwinderman, A.H., Winter, R.J. de, Tio, R.A., Doevendans, P.A.F.M., Waltenberger, J., Maat, M.P.M. de, Frants, R.R., Atsma, D.E., Laarse, A. van der, Wall, E.E. van der, Jukema, J.W.

Publikováno v: European Heart Journal, 13, 25, 1163-1170

Aims To document the practice of interventional cardiology and the clinical restenosis rate, as well as the risk factors for clinical restenosis in an unselected population of patients in daily practice and to provide a perspective for the need of ne

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