Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin.

Autor: Tang Q; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Fakih HH; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Zain Ui Abideen M; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Hildebrand SR; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Afshari K; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Gross KY; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Sousa J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Maebius AS; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Bartholdy C; LEO Pharma A/S, Industriparken 55, 2750, Ballerup, Denmark., Søgaard PP; LEO Pharma A/S, Industriparken 55, 2750, Ballerup, Denmark., Jackerott M; LEO Pharma A/S, Industriparken 55, 2750, Ballerup, Denmark., Hariharan V; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Summers A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Fan X; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Okamura K; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Monopoli KR; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.; Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA, 01609, USA., Cooper DA; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Echeverria D; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Bramato B; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., McHugh N; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Furgal RC; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Dresser K; Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Winter SJ; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Biscans A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Chuprin J; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Haddadi NS; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Sherman S; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Yıldız-Altay Ü; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Rashighi M; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Richmond JM; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Bouix-Peter C; Aldena Therapeutics, London, E1 6RA, UK., Blanchard C; Aldena Therapeutics, London, E1 6RA, UK., Clauss A; LEO Pharma A/S, Industriparken 55, 2750, Ballerup, Denmark., Alterman JF; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. Julia.Alterman@umassmed.edu., Khvorova A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. Anastasia.Khvorova@umassmed.edu.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. Anastasia.Khvorova@umassmed.edu., Harris JE; Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. John.Harris@umassmed.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Nov 04; Vol. 14 (1), pp. 7099. Date of Electronic Publication: 2023 Nov 04.

Functional features defining the efficacy of cholesterol-conjugated, self-deliverable, chemically modified siRNAs.

Autor: Shmushkovich T; Advirna, 60 Prescott Street, Worcester, MA 01605, USA., Monopoli KR; Advirna, 60 Prescott Street, Worcester, MA 01605, USA., Homsy D; Advirna, 60 Prescott Street, Worcester, MA 01605, USA., Leyfer D; Advirna, 60 Prescott Street, Worcester, MA 01605, USA.; Boston University, 44 Cummington Mall, Boston, MA 02215, USA., Betancur-Boissel M; Advirna, 60 Prescott Street, Worcester, MA 01605, USA., Khvorova A; University of Massachusetts Medical School, 368 Plantation Street. Worcester, MA 01655, USA., Wolfson AD; Advirna, 60 Prescott Street, Worcester, MA 01605, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2018 Nov 16; Vol. 46 (20), pp. 10905-10916.