Výsledky vyhledávání - "Mononuclear/metabolism"

Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis

Autor: Pedersen, Janni Maria, Hansen, Aida Solhøj, Skejø, Cæcilie, Juul-Madsen, Kristian, Junker, Peter, Hørslev-Petersen, Kim, Hetland, Merete Lund, Stengaard-Pedersen, Kristian, Østergaard, Mikkel, Møller, Bjarne Kuno, Dreyer, Lene, Hauge, Ellen-Margrethe, Hvid, Malene, Greisen, Stinne, Deleuran, Bent

Publikováno v: Pedersen, J M, Hansen, A S, Skejø, C, Juul-Madsen, K, Junker, P, Hørslev-Petersen, K, Hetland, M L, Stengaard-Pedersen, K, Østergaard, M, Møller, B K, Dreyer, L, Hauge, E M, Hvid, M, Greisen, S & Deleuran, B 2023, ' Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis ', Arthritis Research and Therapy, vol. 25, no. 1, 97 . https://doi.org/10.1186/s13075-023-03073-z
Pedersen, J M, Hansen, A S, Skejø, C, Juul-Madsen, K, Junker, P, Hørslev-Petersen, K, Hetland, M L, Stengaard-Pedersen, K, Østergaard, M, Møller, B K, Dreyer, L, Hauge, E-M, Hvid, M, Greisen, S & Deleuran, B 2023, ' Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis ', Arthritis Research & Therapy, vol. 25, no. 1, 97 . https://doi.org/10.1186/s13075-023-03073-z

BackgroundLymphocyte activation gene-3 (LAG-3) inhibits T cell activation and interferes with the immune response by binding to MHC-II. As antigen presentation is central in rheumatoid arthritis (RA) pathogenesis, we studied aspects of LAG-3 as a ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::33271edfee5f653ef0d5ee2daad97e49
https://pure.au.dk/portal/da/publications/lymphocyte-activation-gene-3-is-increased-and-affects-cytokine-production-in-rheumatoid-arthritis(c4cab09a-a3fc-44ba-8234-a4ecf3785a17).html

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Development of HIV-Resistant CAR T Cells by CRISPR/Cas-Mediated CAR Integration into the CCR5 Locus

Autor: Frederik Holm Rothemejer, Nanna Pi Lauritsen, Anna Karina Juhl, Mariane Høgsbjerg Schleimann, Saskia König, Ole Schmeltz Søgaard, Rasmus O. Bak, Martin Tolstrup

Publikováno v: Rothemejer, F H, Lauritsen, N P, Juhl, A K, Schleimann, M H, König, S, Søgaard, O S, Bak, R & Tolstrup, M 2023, ' Development of HIV-Resistant CAR T Cells by CRISPR/Cas-Mediated CAR Integration into the CCR5 Locus ', Viruses, vol. 15, no. 1, 202 . https://doi.org/10.3390/v15010202
Viruses; Volume 15; Issue 1; Pages: 202
Rothemejer, F H, Lauritsen, N P, Juhl, A K, Schleimann, M H, König, S, Søgaard, O S, Bak, R O & Tolstrup, M 2023, ' Development of HIV-Resistant CAR T Cells by CRISPR/Cas-Mediated CAR Integration into the CCR5 Locus. ', Viruses, vol. 15, no. 1 . https://doi.org/10.3390/v15010202
Aarhus University

Adoptive immunotherapy using chimeric antigen receptor (CAR) T cells has been highly successful in treating B cell malignancies and holds great potential as a curative strategy for HIV infection. Recent advances in the use of anti-HIV broadly neutral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6982bf438e0b4ee8cf04b74e7e28476f
https://pure.au.dk/portal/da/publications/development-of-hivresistant-car-t-cells-by-crisprcasmediated-car-integration-into-the-ccr5-locus(5fd8a15e-8bbf-4d61-9d7c-457bfd30d489).html

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Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers

Autor: Aarón D. Ramírez-Sánchez, Xiaojing Chu, Rutger Modderman, Yvonne Kooy-Winkelaar, Sibylle Koletzko, Ilma R. Korponay-Szabó, Riccardo Troncone, Cisca Wijmenga, Luisa Mearin, Sebo Withoff, Iris H. Jonkers, Yang Li

Publikováno v: Frontiers in Immunology, 13:843086. Frontiers Media SA
Frontiers in Immunology, 13. FRONTIERS MEDIA SA

Celiac Disease (CeD) is a complex immune disorder involving villous atrophy in the small intestine that is triggered by gluten intake. Current CeD diagnosis is based on late-stage pathophysiological parameters such as detection of specific antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9858fba83e631585389f7d9dff40b6
https://pubmed.ncbi.nlm.nih.gov/35371081

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Reliable blood cancer cells' telomere length evaluation by qPCR

Autor: Joana Ropio, Alain Chebly, Jacky Ferrer, Martina Prochazkova‐Carlotti, Yamina Idrissi, Lamia Azzi‐Martin, David Cappellen, Anne Pham‐Ledard, Paula Soares, Jean‐Philippe Merlio, Edith Chevret

Publikováno v: Cancer Medicine
Cancer Medicine, Vol 9, Iss 9, Pp 3153-3162 (2020)

Background Telomere shortening is linked to a range of different human diseases, hence reliable measurement methods are needed to uncover such associations. Among the plethora of telomere length measurement methods, qPCR is reported as easy to conduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c2106f1cc1c4765fafae4f52115d7655
http://europepmc.org/articles/PMC7196062

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Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study

Publikováno v: eLife, Vol 11 (2022)
eLife
eLife, vol. 11, pp. e70393

Background:In a phase 3 trial in African infants and children, the RTS,S/AS01 vaccine (GSK) showed moderate efficacy against clinical malaria. We sought to further understand RTS,S/AS01-induced immune responses associated with vaccine protection.Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f39dda5f2f260731aea5887d8a00c2

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SLAMF Receptor Expression Identifies an Immune Signature That Characterizes Systemic Lupus Erythematosus

Autor: Morgane Humbel, Florence Bellanger, Alice Horisberger, Madeleine Suffiotti, Natalia Fluder, Mariko Makhmutova, Amandine Mathias, Renaud Du Pasquier, Craig Fenwick, Camillo Ribi, Denis Comte

Publikováno v: Frontiers in immunology, vol. 13, pp. 843059

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology, linked to alterations in both the innate and the adaptive immune system. Due to the heterogeneity of the clinical presentation, the diagnosis of SLE remains compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16db8881fda274b931548534edd97e6c
https://pubmed.ncbi.nlm.nih.gov/35603218

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Rapid Generation of TCR and CD8αβ Transgenic Virus Specific T Cells for Immunotherapy of Leukemia

Autor: Bajwa, G., Arber, C.

Publikováno v: Frontiers in immunology, vol. 13, pp. 830021

Virus-specific T cells (VSTs) are an attractive cell therapy platform for the delivery of tumor-targeted transgenic receptors. However, manufacturing with conventional methods may require several weeks and intensive handling. Here we evaluated the fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e4e5736d2ae61bcf49bd16f09c0f373f
https://pubmed.ncbi.nlm.nih.gov/35572604

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Immunomodulation of RA Patients’ PBMC with a Multiepitope Peptide Derived from Citrullinated Autoantigens

Autor: Yehuda Shoenfeld, Martin Cornillet, Sivan Vainer, Gidi Karmon, Smadar Gertel, Ora Shovman, Howard Amital, Guy Serre

Publikováno v: Mediators of Inflammation, Vol 2017 (2017)
Mediators of Inflammation
Mediators of Inflammation, Hindawi Publishing Corporation, 2017, 2017, 9 p. ⟨10.1155/2017/3916519⟩
Mediators of Inflammation, 2017, 2017, 9 p. ⟨10.1155/2017/3916519⟩

Citrullinated peptides are used for measuring anticitrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA). Accumulation of citrullinated proteins in the inflamed synovium suggests that they may be good targets for inducing peripheral tol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15831086b257a571ad5a4b40fc758bc
https://doaj.org/article/25e206a157b944d092668e9a667d5b25

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