Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Monocytes/drug effects"'
Autor:
Peter Libby, Vanessa Frodermann, Friedrich Felix Hoyer, Christoph J. Binder, Christopher T. Chan, Annemijn F. Gregory, Yoshiko Iwamoto, Anne Vassalli, Cameron S. McAlpine, Matthias Nahrendorf, Atsushi Anzai, Filip K. Swirski, Thomas E. Scammell, Shun He, Florian Kahles, Wolfram C. Poller, Ashley M. Fenn, Mehdi Tafti, John E. Mindur, Colin Valet, Sara Rattik, Lennard Halle, M. Kiss
Publikováno v:
Nature
Nature, vol. 566, no. 7744, pp. 383-387
Nature, vol. 566, no. 7744, pp. 383-387
Sleep is integral to life 1 . Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular disease 2 , we know little about the cellular and molecular mechanisms by which sleep maintains ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce735b02272ecc0fdf0ecec71fd5eaa
http://europepmc.org/articles/PMC6442744
http://europepmc.org/articles/PMC6442744
Autor:
Daniel Peckham, Paul Whitaker, Anil Mehta, Sinisa Savic, Michael F. McDermott, T. Scambler, J. Holbrook, Christine Etherington, Ian Clifton, Heledd H. Jarosz-Griffiths, Samuel Lara-Reyna, Giulia Spoletini, C. Wong, Fabio Martinon
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, vol. 9, pp. e54556
eLife, Vol 9 (2020)
eLife, vol. 9, pp. e54556
Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56c3b19820b0ec649de1acb486b5ee6
https://eprints.whiterose.ac.uk/158253/7/elife-54556-v2.pdf
https://eprints.whiterose.ac.uk/158253/7/elife-54556-v2.pdf
Autor:
Torben Plesner, René J. P. Musters, Berris van Kessel, Jeroen F. van Velzen, A. Kate Sasser, Pino J. Poddighe, Marloes E.C. Broekmans, Tuna Mutis, Inger S. Nijhof, Henk M. Lokhorst, Jakub Krejcik, Richard W.J. Groen, Kris A. Frerichs, Sonja Zweegman, Niels W.C.J. van de Donk, Andries C. Bloem, Johan van Meerloo, Christopher Chiu
Publikováno v:
Krejcik, J, Frerichs, K A, Nijhof, I S, van Kessel, B, van Velzen, J, Bloem, A C, Broekmans, M, Zweegman, S, van Meerloo, J, Musters, R J, Poddighe, P, Groen, R, Chiu, C, Plesner, T, Lokhorst, H M, Sasser, A K, Mutis, T & van de Donk, N W C J 2017, ' Monocytes and granulocytes reduce CD38 expression levels on myeloma cells in patients treated with daratumumab ', Clinical Cancer Research, vol. 23, no. 24, pp. 7498-7511 . https://doi.org/10.1158/1078-0432.CCR-17-2027
Krejcik, J, Frerichs, K A, Nijhof, I S, van Kessel, B, van Velzen, J F, Bloem, A C, Broekmans, M E C, Zweegman, S, van Meerloo, J, Musters, R J P, Poddighe, P J, Groen, R W J, Chiu, C, Plesner, T, Lokhorst, H M, Sasser, A K, Mutis, T & van de Donk, N W C J 2017, ' Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab ', Clinical Cancer Research, vol. 23, no. 24, pp. 7498-7511 . https://doi.org/10.1158/1078-0432.CCR-17-2027
Clinical Cancer Research, 23(24), 7498-7511. American Association for Cancer Research Inc.
Krejcik, J, Frerichs, K A, Nijhof, I S, van Kessel, B, van Velzen, J F, Bloem, A C, Broekmans, M E C, Zweegman, S, van Meerloo, J, Musters, R J P, Poddighe, P J, Groen, R W J, Chiu, C, Plesner, T, Lokhorst, H M, Sasser, A K, Mutis, T & van de Donk, N W C J 2017, ' Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab ', Clinical Cancer Research, vol. 23, no. 24, pp. 7498-7511 . https://doi.org/10.1158/1078-0432.CCR-17-2027
Clinical Cancer Research, 23(24), 7498-7511. American Association for Cancer Research Inc.
Purpose: Daratumumab treatment results in a marked reduction of CD38 expression on multiple myeloma cells. The aim of this study was to investigate the clinical implications and the underlying mechanisms of daratumumab-mediated CD38 reduction. Experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a411b4972ab21d4db661d3cca064dd68
https://doi.org/10.1158/1078-0432.ccr-17-2027
https://doi.org/10.1158/1078-0432.ccr-17-2027
Autor:
Delphine Gomez, Gabriel F. Alencar, Richard A. Baylis, Gwendalyn J. Randolph, Gary K. Owens, Ari Waisman, Hermann Gram, Brittany G Durgin, Emmanuel Pinteaux, Sheila E. Francis, Werner Müller, Cynthia St. Hilaire, Alexandra A. C. Newman, Sidney Mahan
Publikováno v:
Gomez, D, Baylis, R A, Durgin, B G, Newman, A A C, Alencar, G F, Mahan, S, St Hilaire, C, Müller, W, Waisman, A, Francis, S E, Pinteaux, E, Randolph, G J, Gram, H & Owens, G K 2018, ' Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice ', Nature Medicine, vol. 24, no. 9, pp. 1418-1429 . https://doi.org/10.1038/s41591-018-0124-5
Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis is that reducing inflammation may improve advanced plaque stability, as recently tested in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc152823fb300249ec1a487a7bb3cf2
https://doi.org/10.1038/s41591-018-0124-5
https://doi.org/10.1038/s41591-018-0124-5
Autor:
Mohamed Chibane, Gérard Lizard, Amira Zarrouk, Pierre Andreoletti, Samia Hadj-Ahmed, Khodir Madani, Fatiha Brahmi, Lila Boulekbache-Makhlouf, Anne Vejux, Maryem Bezine, Thomas Nury
Publikováno v:
Pharmaceutical Biology
Pharmaceutical Biology, Taylor & Francis, 2017, 55 (1), pp.286-293. 〈10.1080/13880209.2016.1235208〉
Pharmaceutical Biology, Taylor & Francis, 2017, 55 (1), pp.286-293. ⟨10.1080/13880209.2016.1235208⟩
Pharmaceutical Biology, Vol 55, Iss 1, Pp 286-293 (2017)
Scopus-Elsevier
Pharmaceutical Biology, Taylor & Francis, 2017, 55 (1), pp.286-293. 〈10.1080/13880209.2016.1235208〉
Pharmaceutical Biology, Taylor & Francis, 2017, 55 (1), pp.286-293. ⟨10.1080/13880209.2016.1235208⟩
Pharmaceutical Biology, Vol 55, Iss 1, Pp 286-293 (2017)
Scopus-Elsevier
International audience; Context: Mints (Lamiaceae) are used as traditional remedies for the treatment of several diseases. Their extracts are recognized as anti-inflammatory compounds. Objective: This study characterized the cytotoxic effects of Ment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ec80bc4ec1a1d47a2f5aecf14413d9
https://hal.archives-ouvertes.fr/hal-01513649
https://hal.archives-ouvertes.fr/hal-01513649
Autor:
Nipa Decroix, Anne Hosmalin, Jean-Pierre Jourdain, Anne-Sophie Liovat, Odile Launay, Christiane Deveau, Michaela Müller-Trutwin, Matthieu Goguet, Charles-Antoine Dutertre, Sonia Amraoui, Pierre Loulergue, Laurence Meyer, Vincent Feuillet, Séverine A. Degrelle, Annalisa DeRosa, Cécile Goujard, Yolande Richard, Lene Vimeux
Publikováno v:
Blood
Blood, American Society of Hematology, 2012, 120 (11), pp.2259-2268. ⟨10.1182/blood-2012-03-418681⟩
Blood, 2012, 120 (11), pp.2259-2268. ⟨10.1182/blood-2012-03-418681⟩
Blood, American Society of Hematology, 2012, 120 (11), pp.2259-2268. ⟨10.1182/blood-2012-03-418681⟩
Blood, 2012, 120 (11), pp.2259-2268. ⟨10.1182/blood-2012-03-418681⟩
HIV infects activated CD4+ T cells and induces their depletion. Progressive HIV infection leading to AIDS is fueled by chronic immune hyperactivation, mediated by inflammatory cytokines like TNFα. This has been related to intestinal epithelial damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb5a4137f647010c8abf343dbc7b070
https://doi.org/10.1182/blood-2012-03-418681
https://doi.org/10.1182/blood-2012-03-418681
Autor:
Wilco W. M. Fleuren, Susanne Bauerschmidt, Ulla Nässander, Marie-Jose van Lierop, Wim H. A. Dokter, Wynand Alkema, Erik J M Toonen
Publikováno v:
Pharmacogenomics, 12, 985-98
Pharmacogenomics, 12, 7, pp. 985-98
Pharmacogenomics, 12(7), 985-998. Ashley
Pharmacogenomics, 12, 7, pp. 985-98
Pharmacogenomics, 12(7), 985-998. Ashley
Background: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1b6544f5e09bddba33579f5c9848f4
https://hdl.handle.net/2066/96208
https://hdl.handle.net/2066/96208
Publikováno v:
Journal of Leukocyte Biology, Vol. 88, No 6 (2010) pp. 1191-1200
sIL-1Ra production induced by IFN-β in human monocytes requires the activation of MEK2 upstream of PI3Kδ, MEK1, and ERK1/2 activation being dispensable. IFN-β and sIL-1Ra play crucial roles in the regulation of innate immunity and inflammation. IF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbab0276ae67a24ed8308e66f50bcce6
https://doi.org/10.1189/jlb.0510312
https://doi.org/10.1189/jlb.0510312
Autor:
François Mach, Fabienne Burger, Claudia Monaco, Fabrizio Montecucco, Graziano Pelli, Sabine Steffens
Publikováno v:
Journal of Leukocyte Biology, Vol. 84, No 4 (2008) pp. 1109-1119
Several studies support C-reactive protein (CRP) as a systemic cardiovascular risk factor. The recent detection of CRP in arterial intima suggests a dual activity in atherosclerosis as a circulating and tissue mediator on vascular and immune cells. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79c18cdc22b5296f32fe47b9e1d2d39
https://doi.org/10.1189/jlb.0208123
https://doi.org/10.1189/jlb.0208123
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)
Oxidative Medicine and Cellular Longevity
Krueger, K, Shen, J, Maier, A, Tepel, M & Scholze, A 2016, ' Lower Superoxide Dismutase 2 (SOD2) Protein Content in Mononuclear Cells Is Associated with Better Survival in Patients with Hemodialysis Therapy ', Oxidative Medicine and Cellular Longevity, vol. 2016, 7423249 . https://doi.org/10.1155/2016/7423249
Oxidative Medicine and Cellular Longevity
Krueger, K, Shen, J, Maier, A, Tepel, M & Scholze, A 2016, ' Lower Superoxide Dismutase 2 (SOD2) Protein Content in Mononuclear Cells Is Associated with Better Survival in Patients with Hemodialysis Therapy ', Oxidative Medicine and Cellular Longevity, vol. 2016, 7423249 . https://doi.org/10.1155/2016/7423249
Mitochondrial superoxide dismutase 2 (SOD2) converts superoxide anions to hydrogen peroxide and oxygen. Human data on SOD2 protein content in chronic kidney disease (CKD) are sparse and mortality data are lacking. We investigated SOD2 protein content
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c066c0891b20e4f7f4ef6d4d9d144cdd
https://doaj.org/article/84bd29541a954ca2befed6ffbbb146e2
https://doaj.org/article/84bd29541a954ca2befed6ffbbb146e2