A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity

Autor: Natascha Roehlen, Antonio Saviano, Houssein El Saghire, Emilie Crouchet, Zeina Nehme, Fabio Del Zompo, Frank Jühling, Marine A. Oudot, Sarah C. Durand, François H. T. Duong, Sara Cherradi, Victor Gonzalez Motos, Nuno Almeida, Clara Ponsolles, Laura Heydmann, Tessa Ostyn, Antonin Lallement, Patrick Pessaux, Emanuele Felli, Andrea Cavalli, Jacopo Sgrignani, Christine Thumann, Olga Koutsopoulos, Bryan C. Fuchs, Yujin Hoshida, Maike Hofmann, Mogens Vyberg, Birgitte Martine Viuff, Elisabeth D. Galsgaard, Greg Elson, Alberto Toso, Markus Meyer, Roberto Iacone, Tamas Schweighoffer, Geoffrey Teixeira, Solange Moll, Claudio De Vito, Tania Roskams, Irwin Davidson, Danijela Heide, Mathias Heikenwälder, Mirjam B. Zeisel, Joachim Lupberger, Laurent Mailly, Catherine Schuster, Thomas F. Baumert

Publikováno v: Roehlen, N, Saviano, A, El Saghire, H, Crouchet, E, Nehme, Z, Del Zompo, F, Jühling, F, Oudot, M A, Durand, S C, Duong, F H T, Cherradi, S, Gonzalez Motos, V, Almeida, N, Ponsolles, C, Heydmann, L, Ostyn, T, Lallement, A, Pessaux, P, Felli, E, Cavalli, A, Sgrignani, J, Thumann, C, Koutsopoulos, O, Fuchs, B C, Hoshida, Y, Hofmann, M, Vyberg, M, Viuff, B M, Galsgaard, E D, Elson, G, Toso, A, Meyer, M, Iacone, R, Schweighoffer, T, Teixeira, G, Moll, S, De Vito, C, Roskams, T, Davidson, I, Heide, D, Heikenwälder, M, Zeisel, M B, Lupberger, J, Mailly, L, Schuster, C & Baumert, T F 2022, ' A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity ', Science Translational Medicine, vol. 14, no. 676, eabj4221, pp. eabj4221 . https://doi.org/10.1126/scitranslmed.abj4221

Tissue fibrosis is a key driver of end-stage organ failure and cancer, overall accounting for up to 45% of deaths in developed countries. There is a large unmet medical need for antifibrotic therapies. Claudin-1 (CLDN1) is a member of the tight junct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a15761706f515b3e02c2102683616d7
https://vbn.aau.dk/da/publications/ae147006-4f6f-4e57-bf99-f23fc8da0fa9

Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans

Autor: J. M. Vicencio, R. Evans, R. Green, Z. An, J. Deng, C. Treacy, R. Mustapha, J. Monypenny, C. Costoya, K. Lawler, K. Ng, K. De-Souza, O. Coban, V. Gomez, J. Clancy, S. H. Chen, A. Chalk, F. Wong, P. Gordon, C. Savage, C. Gomes, T. Pan, G. Alfano, L. Dolcetti, J. N. E. Chan, F. Flores-Borja, P. R. Barber, G. Weitsman, D. Sosnowska, E. Capone, S. Iacobelli, D. Hochhauser, J. A. Hartley, M. Parsons, J. N. Arnold, S. Ameer-Beg, S. A. Quezada, Y. Yarden, G. Sala, T. Ng

Publikováno v: Vicencio Bustamante, J, Evans, R, Green, R, An, Z, Deng, J, Treacy, C, Mustapha, R, Monypenny of Pitmilly, J, Costoya, C, Lawler, K, Ng, K, Desouza, K, Coban, O, Gomez, V, Clancy, J, Chen, SH, Chalk, A, Wong, F, Gordon, P, Savage, C, Gomes, C, Pan, T, Alfano, G, Dolcetti, L, Chan, J N E, Florez-Borja, F, Barber, P, Weitsman, G, Sosnowska, D, Capone, E, Iacobelli, S, Hochhauser, D, Hartley, J, Parsons, M, Arnold, J, Ameer-Beg, S, Quezada, S A, Yarden, Y, Sala, G & Ng, T 2022, ' Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans ', Cell Death & Disease, vol. 13, no. 3, 274 . https://doi.org/10.1038/s41419-022-04701-3

Over the past decade, immunotherapy delivered novel treatments for many cancer types. However, lung cancer still leads cancer mortality, and non-small-cell lung carcinoma patients with mutant EGFR cannot benefit from checkpoint inhibitors due to toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38cc7d5dda59f56e6153cd5799bf0cb
https://kclpure.kcl.ac.uk/ws/files/171263143/s41419_022_04701_3.pdf

Outcome of treatment with carfilzomib before and after treatment with daratumumab in relapsed or refractory multiple myeloma patients

Autor: Marie Fredslund Breinholt, Carsten Helleberg, Agoston Gyula Szabo, Mette Bøegh Levring, Katrine Nielsen, Eigil Kjeldsen, Søren Bønløkke, Katrine Fladeland Iversen, Mette K. Andersen, Birgitte Preiss, Elena Manuela Teodorescu, Emil Hermansen, Lise Mette Rahbek Gjerdrum, Henrik Gregersen, Eva Kurt, Casper Strandholdt, Tobias Wirenfeldt Klausen, Annette Juul Vangsted, Karen Louise Højholt

Publikováno v: Højholt, K L, Gregersen, H, Szabo, A G, Klausen, T W, Levring, M B, Preiss, B, Helleberg, C, Breinholt, M F, Hermansen, E, Rahbek Gjerdrum, L M, Bønløkke, S T, Nielsen, K, Kjeldsen, E, Iversen, K F, Teodorescu, E M, Kurt, E, Strandholdt, C, Andersen, M K & Vangsted, A J 2021, ' Outcome of treatment with carfilzomib before and after treatment with daratumumab in relapsed or refractory multiple myeloma patients ', Hematological Oncology, vol. 39, no. 4, pp. 521-528 . https://doi.org/10.1002/hon.2906

Real world evidence is important since most patients cannot be included in randomized clinical trials (RCTs). In a nationwide, cohort of relapsed/refractory multiple myeloma patients treated with daratumumab (N = 635), we retrospective studied patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61024888296e62b7a6177aeb85a53828
https://portal.findresearcher.sdu.dk/da/publications/3205a743-e998-4521-9f10-c9df06ddd93b

Migraine induction with calcitonin gene-related peptide in patients from erenumab trials

Autor: Sabrina Khan, Samaira Younis, Hashmat Ghanizada, Marie Deen, Casper Emil Christensen, Messoud Ashina

Publikováno v: The Journal of Headache and Pain, Vol 19, Iss 1, Pp 1-9 (2018)
The Journal of Headache and Pain
Christensen, C E, Younis, S, Deen, M, Khan, S, Ghanizada, H & Ashina, M 2018, ' Migraine induction with calcitonin gene-related peptide in patients from erenumab trials ', The Journal of Headache and Pain, vol. 19, 105 . https://doi.org/10.1186/s10194-018-0927-2

BACKGROUND: Migraine prevention with erenumab and migraine induction by calcitonin gene-related peptide (CGRP) both carry notable individual variance. We wanted to explore a possible association between individual efficacy of anti-CGRP treatment and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e314e3c021ad0c3d9fa45cc0e683da4
http://link.springer.com/article/10.1186/s10194-018-0927-2

SGM-101: An innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery

Autor: Marian Gutowski, Véronique Garambois, André Pèlegrin, Bérénice Framery, François Scherninski, Françoise Cailler, Alexander L. Vahrmeijer, Martin C. Boonstra, Karen Dumas, François Quenet

Publikováno v: Surgical Oncology, 26(2), 153-162
Surgical Oncology
Surgical Oncology, Elsevier, 2017, 26 (2), pp.153-162. ⟨10.1016/j.suronc.2017.03.002⟩

International audience; PURPOSE:Fluorescence-guided surgery (FGS) provides surgeons with new opportunities to improve real-time cancer nodule detection and tumor margin visualization. Currently, the most important challenge in this field is the devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4867c75678163ba1326b86d07f8e1f83
https://doi.org/10.1016/j.suronc.2017.03.002