Zobrazeno 1 - 10 of 220 pro vyhledávání: '"Monk SA"'
1
Akademický článek
Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species.
Autor: Willis BA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Lowe SL; Lilly Centre for Clinical Pharmacology, Singapore, Singapore., Monk SA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Cocke PJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Aluise CD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Boggs LN; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Borders AR; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Brier RA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Dean RA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Green SJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., James DE; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Jhee SS; PAREXEL International, Glendale, CA, USA., Lin Q; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Lo AC; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., May PC; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Watson BM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Winneroski LL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Yang Z; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Zimmer JA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., McKinzie DL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Mergott DJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.
Publikováno v: Journal of Alzheimer's disease reports [J Alzheimers Dis Rep] 2022 Jan 11; Vol. 6 (1), pp. 1-15. Date of Electronic Publication: 2022 Jan 11 (Print Publication: 2022).
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2
Akademický článek
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
Autor: McKinzie DL; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Winneroski LL; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Green SJ; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Hembre EJ; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Erickson JA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Willis BA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Monk SA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Aluise CD; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Baker TK; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Lopez JE; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Hendle J; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Biotechnology Center, San Diego, California 92121, United States., Beck JP; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Biotechnology Center, San Diego, California 92121, United States., Brier RA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Boggs LN, Borders AR; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Cocke PJ, Garcia-Losada P; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Lowe SL; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Mathes BM; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., May PC, Porter WJ, Stout SL; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Timm DE; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Watson BM; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Yang Z; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States., Mergott DJ; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Jun 24; Vol. 64 (12), pp. 8076-8100. Date of Electronic Publication: 2021 Jun 03.
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3
Akademický článek
Clinically Negligible Pharmacokinetic and Pharmacodynamic Interactions Between Lanabecestat and Dabigatran Etexilate, a Prototypical P-gp Substrate.
Autor: Monk SA; Eli Lilly and Company, Indianapolis, Indiana., Kugler AR; AstraZeneca, Waltham, Massachusetts., Andersen SW; Eli Lilly and Company, Indianapolis, Indiana., Ayan-Oshodi MA; Eli Lilly and Company, Indianapolis, Indiana., James DE; Eli Lilly and Company, Indianapolis, Indiana., Mullen J; AstraZeneca, Waltham, Massachusetts., Zimmer JA; Eli Lilly and Company, Indianapolis, Indiana., Willis BA; Eli Lilly and Company, Indianapolis, Indiana.
Publikováno v: Journal of clinical pharmacology [J Clin Pharmacol] 2020 May; Vol. 60 (5), pp. 586-594. Date of Electronic Publication: 2019 Dec 18.
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4
Akademický článek
Enhanced phagocytosis associated with multinucleated microglia via Pyk2 inhibition in an acute β-amyloid infusion model.
Autor: Lee, Ji-Won1 (AUTHOR) jwlee@den.hokudai.ac.jp, Mizuno, Kaito1,2 (AUTHOR), Watanabe, Haruhisa3,4 (AUTHOR), Lee, In-Hee5 (AUTHOR), Tsumita, Takuya6 (AUTHOR), Hida, Kyoko6 (AUTHOR), Yawaka, Yasutaka2 (AUTHOR), Kitagawa, Yoshimasa4 (AUTHOR), Hasebe, Akira1 (AUTHOR), Iimura, Tadahiro3 (AUTHOR), Kong, Sek Won5,7 (AUTHOR)
Publikováno v: Journal of Neuroinflammation. 8/6/2024, Vol. 21 Issue 1, p1-19. 19p.
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5
Akademický článek
Assessment of Transporter Polymorphisms as a Factor in a BCRP Drug Interaction Study With Lanabecestat.
Autor: Willis BA; Eli Lilly and Company, Indianapolis, Indiana, USA., Andersen SW; Eli Lilly and Company, Indianapolis, Indiana, USA., Ayan-Oshodi M; Eli Lilly and Company, Indianapolis, Indiana, USA., James DE; Eli Lilly and Company, Indianapolis, Indiana, USA., Liffick E; Eli Lilly and Company, Indianapolis, Indiana, USA., Hillgren K; Eli Lilly and Company, Indianapolis, Indiana, USA., Guo Y; Eli Lilly and Company, Indianapolis, Indiana, USA., Monk SA; Eli Lilly and Company, Indianapolis, Indiana, USA.
Publikováno v: Journal of clinical pharmacology [J Clin Pharmacol] 2020 Jan; Vol. 60 (1), pp. 107-116. Date of Electronic Publication: 2019 Aug 05.
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6
Akademický článek
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Autor: Winneroski LL; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Erickson JA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Green SJ; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Lopez JE; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Stout SL; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Porter WJ, Timm DE, Audia JE; Constellation Pharmaceuticals, Cambridge, MA 02140, USA(2)., Barberis M; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Beck JP; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Boggs LN, Borders AR; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Boyer RD; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Brier RA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Hembre EJ; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Hendle J; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Biotechnology Center, San Diego, CA 92121, USA., Garcia-Losada P; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Minguez JM; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Mathes BM; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., May PC, Monk SA; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Rankovic Z; Chemical Biology & Therapeutics St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA(2)., Shi Y; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Watson BM; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Yang Z; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA., Mergott DJ; Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. Electronic address: mergottdu@lilly.com.
Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Jan 01; Vol. 28 (1), pp. 115194. Date of Electronic Publication: 2019 Nov 15.
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7
Akademický článek
Rapid Mapping of Dissolved Methane and Carbon Dioxide in Coastal Ecosystems Using the ChemYak Autonomous Surface Vehicle.
Autor: Nicholson DP; Marine Chemistry and Geochemistry Department , Woods Hole Oceanographic Institution , Woods Hole , Massachusetts 02543 , United States., Michel APM; Applied Ocean Physics and Engineering Department , Woods Hole Oceanographic Institution , Woods Hole , Massachusetts 02543 , United States., Wankel SD; Marine Chemistry and Geochemistry Department , Woods Hole Oceanographic Institution , Woods Hole , Massachusetts 02543 , United States., Manganini K; Applied Ocean Physics and Engineering Department , Woods Hole Oceanographic Institution , Woods Hole , Massachusetts 02543 , United States., Sugrue RA; Applied Ocean Physics and Engineering Department , Woods Hole Oceanographic Institution , Woods Hole , Massachusetts 02543 , United States., Sandwith ZO; Marine Chemistry and Geochemistry Department , Woods Hole Oceanographic Institution , Woods Hole , Massachusetts 02543 , United States., Monk SA; Applied Ocean Physics and Engineering Department , Woods Hole Oceanographic Institution , Woods Hole , Massachusetts 02543 , United States.
Publikováno v: Environmental science & technology [Environ Sci Technol] 2018 Nov 20; Vol. 52 (22), pp. 13314-13324. Date of Electronic Publication: 2018 Nov 07.
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8
Akademický článek
Clinical Bioavailability of the Novel BACE1 Inhibitor Lanabecestat (AZD3293): Assessment of Tablet Formulations Versus an Oral Solution and the Impact of Gastric pH on Pharmacokinetics.
Autor: Ye N; AstraZeneca, Cambridge, MA, USA., Monk SA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Daga P; AstraZeneca, Cambridge, MA, USA., Bender DM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA., Rosen LB; AstraZeneca, Cambridge, MA, USA., Mullen J; AstraZeneca, Cambridge, MA, USA., Minkwitz MC; AstraZeneca, Cambridge, MA, USA., Kugler AR; AstraZeneca, Cambridge, MA, USA.
Publikováno v: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2018 Mar; Vol. 7 (3), pp. 233-243. Date of Electronic Publication: 2018 Jan 10.
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9
Akademický článek
Simultaneous quantitation of the BACE1 inhibitor AZD3293 and its metabolite AZ13569724 in human matrices by LC-MS/MS.
Autor: Li Y; Early Clinical Development, IMED Biotech Unit, AstraZeneca, Waltham, MA, USA 02451., Severin PH; Clinical Laboratories, Covance Laboratories, Inc., Madison, WI, USA 53704., Hoffmann MR; Clinical Laboratories, Covance Laboratories, Inc., Madison, WI, USA 53704., Miller DL; Clinical Laboratories, Covance Laboratories, Inc., Madison, WI, USA 53704., Monk SA; Drug Disposition, Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN, USA 46285., Kugler AR; Clinical Pharmacology, Coastal Pharma Group, Concord, MA, USA 01742.
Publikováno v: Bioanalysis [Bioanalysis] 2017 May; Vol. 9 (10), pp. 813-826. Date of Electronic Publication: 2017 Apr 24.
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10
Akademický článek
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