Zobrazeno 1 - 10 of 223 pro vyhledávání: '"Monk PD"'
1
Akademický článek
Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2.
Autor: Bell JA; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK., Davies ER; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK; Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, SO17 1BJ Southampton, UK., Brereton CJ; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK., Vukmirovic M; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Roberts JJW; Synairgen Research Ltd, Southampton, UK., Lunn K; Synairgen Research Ltd, Southampton, UK., Wickens L; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK; Institute for Life Sciences, University of Southampton, SO17 1BJ Southampton, UK., Conforti F; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK., Ridley RA; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK., Ceccato J; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK; Department of Medicine, University of Padova, Padova, Italy., Sayer LN; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK., Johnston DA; Biomedical Imaging Unit, Faculty of Medicine, University of Southampton, Southampton, UK., Vallejo AF; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK., Alzetani A; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK; University Hospital Southampton, SO16 6YD Southampton, UK., Jogai S; University Hospital Southampton, SO16 6YD Southampton, UK., Marshall BG; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK; University Hospital Southampton, SO16 6YD Southampton, UK., Fabre A; Department of Histopathology, St. Vincent's University Hospital & UCD School of Medicine, University College Dublin, Dublin, Ireland., Richeldi L; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK; Unità Operativa Complessa di Pneumologia, Università Cattolica del Sacro Cuore, Fondazione Policlinico A. Gemelli, Rome, Italy., Monk PD; Synairgen Research Ltd, Southampton, UK., Skipp P; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK; Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, SO17 1BJ Southampton, UK; University Hospital Southampton, SO16 6YD Southampton, UK., Kaminski N; Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA., Offer E; Medicines Discovery Catapult, Alderley Edge, UK., Wang Y; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK; Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, SO17 1BJ Southampton, UK; Institute for Life Sciences, University of Southampton, SO17 1BJ Southampton, UK., Davies DE; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK; Institute for Life Sciences, University of Southampton, SO17 1BJ Southampton, UK., Jones MG; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, SO16 6YD Southampton, UK; Institute for Life Sciences, University of Southampton, SO17 1BJ Southampton, UK. Electronic address: mark.jones@soton.ac.uk.
Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Sep 17; Vol. 5 (9), pp. 101695. Date of Electronic Publication: 2024 Aug 21.
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2
Akademický článek
Nebulised interferon beta-1a (SNG001) in the treatment of viral exacerbations of COPD.
Autor: Monk PD; Synairgen Research Ltd, Southampton, UK. phillip.monk@synairgen.com., Brookes JL; Synairgen Research Ltd, Southampton, UK., Tear VJ; Synairgen Research Ltd, Southampton, UK., Batten TN; Veramed, Twickenham, London, UK., Newall C; Veramed, Twickenham, London, UK., Mankowski M; Synairgen Research Ltd, Southampton, UK.; tranScrip Ltd, Wokingham, UK., Crooks MG; Respiratory Research Group, Hull York Medical School, University of Hull, Kingston Upon Hull, Hull, UK., Singh D; Medicines Evaluation Unit, The University of Manchester, Manchester University NHS Foundation Trust, Manchester, UK., Chaudhuri R; Gartnavel General Hospital, Glasgow, UK.; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Leaker B; Respiratory Clinical Trials Ltd, Fitzrovia Hospital, London, UK., Lunn K; Synairgen Research Ltd, Southampton, UK., Reynolds S; Synairgen Research Ltd, Southampton, UK., Dudley S; Synairgen Research Ltd, Southampton, UK., Gabbay FJ; tranScrip Ltd, Wokingham, UK., Holgate ST; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK., Djukanovic R; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK., Wilkinson TM; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK.
Publikováno v: Respiratory research [Respir Res] 2024 May 29; Vol. 25 (1), pp. 228. Date of Electronic Publication: 2024 May 29.
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3
Akademický článek
Feasibility of home administration of nebulised interferon ß-1a (SNG001) for COVID-19: a remote study.
Autor: Francis NA; Primary Care Research Centre, Faculty of Medicine, University of Southampton, Aldermoor Health Centre, Southampton, UK nick.francis@soton.ac.uk., Monk PD; Synairgen Research Ltd, Southampton, UK., Nuttall J; Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Oliver T; Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Simpson C; Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Brookes JL; Synairgen Research Ltd, Southampton, UK., Tear VJ; Synairgen Research Ltd, Southampton, UK., Thompson AG; Quinn Clinical Limited, Merseyside, UK., Batten TN; Veramed, Twickenham, London, UK., Mankowski M; tranScrip Ltd, Wokingham, UK., Wilkinson TM; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK.
Publikováno v: BJGP open [BJGP Open] 2023 Dec 19; Vol. 7 (4). Date of Electronic Publication: 2023 Dec 19 (Print Publication: 2023).
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4
Akademický článek
Safety and efficacy of inhaled interferon-β1a (SNG001) in adults with mild-to-moderate COVID-19: a randomized, controlled, phase II trial.
Autor: Jagannathan P; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Chew KW; Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA., Giganti MJ; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hughes MD; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Moser C; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Main MJ; Synairgen Research Ltd, Southampton, United Kingdom., Monk PD; Synairgen Research Ltd, Southampton, United Kingdom., Javan AC; National Institutes of Health, Bethesda, MD, USA., Li JZ; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Fletcher CV; University of Nebraska Medical Center, College of Pharmacy, USA., McCarthy C; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Wohl DA; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Daar ES; Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Eron JJ; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Currier JS; Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA., Singh U; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Smith DM; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Fischer W; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Publikováno v: EClinicalMedicine [EClinicalMedicine] 2023 Oct 06; Vol. 65, pp. 102250. Date of Electronic Publication: 2023 Oct 06 (Print Publication: 2023).
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5
Akademický článek
Nebulised interferon-β1a (SNG001) in hospitalised COVID-19: SPRINTER phase III study.
Autor: Monk PD; Synairgen Research Ltd, Southampton, UK., Brookes JL; Synairgen Research Ltd, Southampton, UK., Tear VJ; Synairgen Research Ltd, Southampton, UK., Batten TN; Veramed, Twickenham, UK., Mankowski M; tranScrip Ltd, Wokingham, UK., Adzic-Vukicevic T; University Clinical Center of Serbia, COVID Hospital Batajnica, Belgrade, Serbia., Crooks MG; Respiratory Research Group, Hull York Medical School, University of Hull, Kingston upon Hull, UK., Dosanjh DPS; Birmingham and West Midlands Lung Research Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Kraft M; Department of Medicine, College of Medicine, Tucson, AZ, USA.; Asthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, AZ, USA., Brightling CE; Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Gabbay FJ; tranScrip Ltd, Wokingham, UK., Holgate ST; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK., Djukanovic R; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK., Wilkinson TMA; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK.
Publikováno v: ERJ open research [ERJ Open Res] 2023 Mar 27; Vol. 9 (2). Date of Electronic Publication: 2023 Mar 27 (Print Publication: 2023).
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7
Akademický článek
Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial.
Autor: Monk PD; Synairgen Research, Southampton General Hospital, Southampton, UK., Marsden RJ; Synairgen Research, Southampton General Hospital, Southampton, UK., Tear VJ; Synairgen Research, Southampton General Hospital, Southampton, UK., Brookes J; Synairgen Research, Southampton General Hospital, Southampton, UK., Batten TN; Veramed, Regal House, Twickenham, UK., Mankowski M; TranScrip Partners, Wokingham, UK., Gabbay FJ; TranScrip Partners, Wokingham, UK., Davies DE; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK., Holgate ST; Synairgen Research, Southampton General Hospital, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK., Ho LP; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, UK., Clark T; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK., Djukanovic R; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK., Wilkinson TMA; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK. Electronic address: t.wilkinson@soton.ac.uk.
Publikováno v: The Lancet. Respiratory medicine [Lancet Respir Med] 2021 Feb; Vol. 9 (2), pp. 196-206. Date of Electronic Publication: 2020 Nov 12.
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8
Akademický článek
Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis.
Autor: Jones MG; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Andriotis OG; Institute for Lightweight Design and Structural Biomechanics, TU Wien, Getreidemarkt, Austria., Roberts JJ; Synairgen Research Ltd, Southampton, United Kingdom., Lunn K; Synairgen Research Ltd, Southampton, United Kingdom., Tear VJ; Synairgen Research Ltd, Southampton, United Kingdom., Cao L; Pharmaxis Ltd, Frenchs Forest, Australia., Ask K; Department of Medicine, Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton, Hamilton, Canada., Smart DE; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Bonfanti A; Aeronautics, Astronautics and Computational Engineering, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom., Johnson P; Department of Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Alzetani A; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; University Hospital Southampton, Southampton, United Kingdom., Conforti F; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Doherty R; Biomedical Imaging Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Lai CY; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Johnson B; CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Bourdakos KN; Department of Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Fletcher SV; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; University Hospital Southampton, Southampton, United Kingdom., Marshall BG; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; University Hospital Southampton, Southampton, United Kingdom., Jogai S; University Hospital Southampton, Southampton, United Kingdom., Brereton CJ; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Chee SJ; University Hospital Southampton, Southampton, United Kingdom.; CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Ottensmeier CH; CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Sime P; Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, United States., Gauldie J; Department of Medicine, Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton, Hamilton, Canada., Kolb M; Department of Medicine, Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton, Hamilton, Canada., Mahajan S; Department of Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Fabre A; Department of Histopathology, St. Vincent's University Hospital & UCD School of Medicine, University College Dublin, Dublin, Ireland., Bhaskar A; Aeronautics, Astronautics and Computational Engineering, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom., Jarolimek W; Pharmaxis Ltd, Frenchs Forest, Australia., Richeldi L; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., O'Reilly KM; Mater Misericordiae University Hospital, Dublin, Ireland.; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland., Monk PD; Synairgen Research Ltd, Southampton, United Kingdom., Thurner PJ; Institute for Lightweight Design and Structural Biomechanics, TU Wien, Getreidemarkt, Austria., Davies DE; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.
Publikováno v: ELife [Elife] 2018 Jul 03; Vol. 7. Date of Electronic Publication: 2018 Jul 03.
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9
Akademický článek
Local fractal dimension of collagen detects increased spatial complexity in fibrosis.
Autor: Casey, Dylan T.1,2 (AUTHOR) dtcasey@uvm.edu, Lahue, Karolyn G.3 (AUTHOR), Mori, Vitor1 (AUTHOR), Herrmann, Jacob4 (AUTHOR), Hall, Joseph K.5 (AUTHOR), Suki, Béla5 (AUTHOR), Janssen-Heininger, Yvonne M. W.3 (AUTHOR), Bates, Jason H. T.1 (AUTHOR)
Publikováno v: Histochemistry & Cell Biology. Jan2024, Vol. 161 Issue 1, p29-42. 14p.
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10
Akademický článek
Dynamical modelling of viral infection and cooperative immune protection in COVID-19 patients.
Autor: Zhou, Zhengqing1 (AUTHOR), Li, Dianjie1 (AUTHOR), Zhao, Ziheng2 (AUTHOR), Shi, Shuyu3 (AUTHOR), Wu, Jianghua4 (AUTHOR), Li, Jianwei1 (AUTHOR), Zhang, Jingpeng1 (AUTHOR), Gui, Ke2 (AUTHOR), Zhang, Yu2 (AUTHOR), Ouyang, Qi1 (AUTHOR), Mei, Heng4 (AUTHOR) hmei@hust.edu.cn, Hu, Yu4 (AUTHOR) hmei@hust.edu.cn, Li, Fangting1 (AUTHOR) hmei@hust.edu.cn
Publikováno v: PLoS Computational Biology. 9/1/2023, Vol. 19 Issue 9, p1-29. 29p. 1 Diagram, 5 Graphs.
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