Výsledky vyhledávání - "Monish, Jain"

Population Pharmacokinetic Analysis of Indacaterol/Glycopyrronium/Mometasone Furoate After Administration of Combination Therapies Using the Breezhaler® Device in Patients with Asthma

Autor: Christian Bartels, Monish Jain, Soniya Vaidya, Jing Yu, Hanns-Christian Tillmann

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics

Background and Objective Clinical evidence suggests no clinically relevant pharmacokinetic interactions between indacaterol (IND), glycopyrronium (GLY) and mometasone furoate (MF). A population pharmacokinetic (popPK) analysis was conducted to identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09b4feb909b3e0203ef93f7191ede8c
http://europepmc.org/articles/PMC8298373

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Use of Intramolecular 1,5-Sulfur–Oxygen and 1,5-Sulfur–Halogen Interactions in the Design of N-Methyl-5-aryl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Splicing Modulators

Autor: Youngah Shin, Moo Je Sung, Monish Jain, Jake Axford, Natalie Dales, Ina Dix, Brian Hurley, Lawrence G. Hamann, Karin Briner, Atwood K. Cheung, John I. Manchester, Donovan N. Chin, Rajeev Sivasankaran

Publikováno v: Journal of Medicinal Chemistry. 64:4744-4761

Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by low levels of functional survival motor neuron protein (SMN) resulting from a deletion or loss of function mutation of the survival motor neuron 1 (SMN1) gene. Branaplam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cb500bf78e4fb0857bfdd9a64443fed
https://doi.org/10.1021/acs.jmedchem.0c02173

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Population Pharmacokinetic Analysis of Fevipiprant in Healthy Subjects and Asthma Patients using a Tukey’s g-and-h Distribution

Autor: Swarupa Kulkarni, Xinting Wang, Jing Yu, Ramachandra Sangana, Monish Jain, Christian Bartels, Julia Zack

Publikováno v: Drug Research. 71:326-334

Aim The objective of this analysis was to characterize the population pharmacokinetics (PK) of fevipiprant in asthma patients and to evaluate the effect of baseline covariates on the PK of fevipiprant. Methods PK data from 1281 healthy subjects or as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b936b6f59837b18d62e37f3dca9aa6bb
https://doi.org/10.1055/a-1381-6579

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Inhaled anti-TSLP antibody fragment, ecleralimab, blocks responses to allergen in mild asthma

Autor: Gail M. Gauvreau, Jens M. Hohlfeld, J. Mark FitzGerald, Louis-Philippe Boulet, Donald W. Cockcroft, Beth E. Davis, Stephanie Korn, Oliver Kornmann, Richard Leigh, Irvin Mayers, Henrik Watz, Sarah S. Grant, Monish Jain, Maciej Cabanski, Peter E. Pertel, Ieuan Jones, Jean R. Lecot, Hui Cao, Paul M. O'Byrne

Publikováno v: European Respiratory Journal. 61:2201193

BackgroundThymic stromal lymphopoietin (TSLP) is a key upstream regulator driving allergic inflammatory responses. We evaluated the efficacy and safety of ecleralimab, a potent inhaled neutralising antibody fragment against human TSLP, using allergen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c558a56acdc88d30ed38dae917698ca
https://doi.org/10.1183/13993003.01193-2022

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Dose bridging data for mometasone furoate in once-daily fixed-dose inhaled combinations of mometasone furoate/indacaterol and mometasone furoate/ indacaterol/glycopyrronium in patients with asthma

Autor: Monish Jain, Hanns-Christian Tillmann, Christian Bartels, Soniya Vaidya, Huib A. M. Kerstjens, Juergen Jauernig, Ivan Nikolaev, Roland Buhl

Publikováno v: Pulmonary Pharmacology & Therapeutics. 70

Once-daily (o.d.) fixed-dose combinations of mometasone furoate/indacaterol acetate (MF/IND) and mometasone furoate/indacaterol acetate/glycopyrronium bromide (MF/IND/GLY), both delivered via the Breezhaler® device, are approved for the maintenance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80903624dbb705ad212fb8a8274052de
https://hdl.handle.net/11370/5f8c3f32-cb60-4cf3-a4f9-455fb94bf489

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Topical Ocular TRPV1 Antagonist SAF312 (Libvatrep) Demonstrates Safety, Low Systemic Exposure, and No Anesthetic Effect in Healthy Participants

Autor: Kalliopi, Stasi, Qusai, Alshare, Monish, Jain, Michael, Wald, Yifang, Li

Publikováno v: Translational Vision Science & Technology. 11:15

This first-in-human (FIH) study evaluated the safety, tolerability, pharmacokinetics, and effect on corneal sensitivity of topical ocular SAF312 in healthy participants.This double-masked, randomized study comprised single-ascending dose (SAD), multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca56b7654633af19b386154fd2daeae
https://doi.org/10.1167/tvst.11.11.15

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Use of Intramolecular 1,5-Sulfur-Oxygen and 1,5-Sulfur-Halogen Interactions in the Design of

Autor: Jake, Axford, Moo Je, Sung, John, Manchester, Donovan, Chin, Monish, Jain, Youngah, Shin, Ina, Dix, Lawrence G, Hamann, Atwood K, Cheung, Rajeev, Sivasankaran, Karin, Briner, Natalie A, Dales, Brian, Hurley

Publikováno v: Journal of medicinal chemistry. 64(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13330dc0c7e19f69d4bd3cf1bf193353
https://pubmed.ncbi.nlm.nih.gov/33822618

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Late Breaking Abstract - Efficacy of CSJ117 on allergen-induced asthmatic responses in mild atopic asthma patients

Autor: Monish Jain, Oliver Kornmann, J. Mark FitzGerald, Richard Leigh, Jens M. Hohlfeld, Donald W. Cockcroft, Hendrik Watz, Beth E. Davis, Ieuan Jones, Gail M. Gauvreau, Louis-Philippe Boulet, Irvin Mayers, Jean Lecot, Stephanie Korn, Paul M. O'Byrne, Peter Pertel, Maciej Cabanski, Sarah Schmidt Grant

Publikováno v: Airway pharmacology and treatment.

Introduction: CSJ117 is a potent neutralizing antibody fragment against human Thymic stromal lymphopoietin (TSLP), formulated as a PulmoSol™ engineered powder in hard capsules for delivery to the lungs via dry powder inhaler. Methods: In this doubl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ba5e6c0ec7aaf92c858d34647e2a398
https://doi.org/10.1183/13993003.congress-2020.3690

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