Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice

Autor: Wim J.G. Oyen, Monique de Visser, Marion de Jong, Erik Vegt, Martin Gotthardt, Maarten Brom, Otto C. Boerman, Annemarie Eek, Marleen Melis

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 38, 4, pp. 623-32
European Journal of Nuclear Medicine and Molecular Imaging, 38(4), 623-632. Springer-Verlag
European Journal of Nuclear Medicine and Molecular Imaging, 38, 623-32
European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging, 38(4), 623-632. Springer, Cham

Contains fulltext : 98302.pdf (Publisher’s version ) (Closed access) PURPOSE: Radiolabelled peptides used for peptide receptor radionuclide therapy are excreted mainly via the kidneys and are partly reabsorbed and retained in the proximal tubular c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024a595520b6054cab8002066b45fe99
https://doi.org/10.1007/s00259-010-1685-9

Androgen-regulated gastrin-releasing peptide receptor expression in androgen-dependent human prostate tumor xenografts

Autor: Corrina M.A. de Ridder, Rogier P. J. Schroeder, Eric P. Krenning, Wout A.P. Breeman, Marleen Melis, Monique de Visser, Suzanne Reneman, Marion de Jong, Wytske M. van Weerden

Publikováno v: International Journal of Cancer, 126(12), 2826-2834. Wiley-Liss Inc.

Human prostate cancer (PC) overexpresses the gastrin-releasing peptide receptor (GRPR). Radiolabeled GRPR-targeting analogs of bombesin (BN) have successfully been introduced as potential tracers for visualization and treatment of GRPR-overexpressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a6f68895ecb1ab28864c11a4668b17
https://hdl.handle.net/1765/25934

Versatile Conjugation of Octreotide to Dendrimers by Cycloaddition ('Click') Chemistry to Yield High-Affinity Multivalent Cyclic Peptide Dendrimers

Autor: Marion de Jong, Annemarie C. Dechesne, Dirk T. S. Rijkers, Monique de Visser, Otto C. Boerman, Rob M. J. Liskamp, Cheng-Bin Yim

Publikováno v: Bioconjugate Chemistry, 20, 7, pp. 1323-31
Bioconjugate Chemistry, 20(7), 1323-1331. American Chemical Society
Bioconjugate Chemistry, 20, 1323-31

Contains fulltext : 80972.pdf (Publisher’s version ) (Closed access) The somatostatin analogue Tyr(3)-octreotide, which has a high binding affinity for the SSTR2 receptor (somatostatin receptor subtype 2) expressed on tumor cells, is used clinicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6aa71a3b064eec47bf3a3ea23b1cffe
https://pure.eur.nl/en/publications/9aedbb6c-2b1c-4102-ad2b-e71687c819d2

Long-term toxicity of [Lu-177-DOTA(0),Tyr(3)]octreotate in rats

Autor: Eric P. Krenning, Theo J. Visser, Magda Bijster, Bert F. Bernard, Marcel Vermeij, Edgar J. Rolleman, Jan Lindemans, Marion de Jong, Monique de Visser

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 34(2), 219-227. Springer-Verlag

Studies on peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues have shown promising results with regard to tumour control. The efficacy of PRRT is limited by uptake and retention in the proximal tubules of the kidn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d082dee83af7fef37cd7ff774224ba5
https://pure.eur.nl/en/publications/735a0644-cdae-4f6c-bfde-2cf156f2d053

Update: improvement strategies for peptide receptor scintigraphy and radionuclide therapy

Autor: Marion de Jong, Monique de Visser, Suzanne M. Verwijnen

Publikováno v: Cancer Biotherapy & Radiopharmaceuticals, 23(2), 137-157. Mary Ann Liebert Inc.

Somatostatin receptor-targeting peptides are widely used for the imaging and therapy of neuroendocrine tumors. Peptide-receptor radionuclide therapy (PRRT) in neuroendocrine tumor patients with radiolabeled somatostatin analogs has resulted in sympto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2481396317d535f494b7d8d577e05799
https://pubmed.ncbi.nlm.nih.gov/18454684