Výsledky vyhledávání - "Monique Zreika"

Haloallylamine inhibitors of MAO and SSAO and their therapeutic potential

Autor: Ian A. McDonald, Philippe Bey, Charles Danzin, G. Cremer, Michael G. Palfreyman, Monique Zreika

Publikováno v: Amine Oxidases: Function and Dysfunction ISBN: 9783211825211

Based on mechanistic understandings, molecular modeling and extensive quantitative structure-activity relationships, appropriately substituted haloallylamine derivatives were designed as potential mechanism-based inhibitors of MAO and/or SSAO. Potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aca4ca1062025f3a242a15de7a11c517
https://doi.org/10.1007/978-3-7091-9324-2_54

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Tyrosine and tryptophan analogues as MAO-inhibiting prodrugs

Autor: Jean-Noel Collard, Philippe Bey, Albert Sjoerdsma, Michael G. Palfreymana, Monique Zreika, Joseph Wagner, Ian A. McDonald

Publikováno v: Amino Acids ISBN: 9789072199041

(E)-s-Fluoromethylene-m-tyrosine (FMMT) and (E)-s-fluoromethylene-5-hydroxytryptophan (FM-5-HTP) are substrates of aromatic L-amino acid decarboxylase and yield the corresponding substituted tyramine and 5-hydroxytryptamine analogues which potently a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3a5847c5f9262fcdc6982b2253be06c
https://doi.org/10.1007/978-94-011-2262-7_43

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MDL-72,974A

Autor: Monique Zreika, M.G. Palfreyman, Philippe Bey, Ian A. McDonald

Publikováno v: Drugs of the Future. 16:428

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6dc6138ef9581f1929cf20eb5e25cb1
https://doi.org/10.1358/dof.1991.016.05.137103

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A method for measuring monoamine turnover in animals using an irreversible inhibitor of aromatic L-amino acid decarboxylase, DL-α-mono fluoromethyldopa

Autor: Michael G. Palfreyman, Joseph Wagner, Monique Zreika, Robert Arbogast

Publikováno v: Journal of Pharmacological Methods. 11:239-251

DL-α-monofluoromethyldopa (MFMD) is a potent enzyme-activated irreversible inhibitor of aromatic L-amino acid decarboxylase which, when given to rats or mice at 100 and 250 mg kg i.p., respectively, causes a linear accumulation of L-DOPA and 5HTP an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657eb73f287209c2bd0fef11895ec14d
https://doi.org/10.1016/0160-5402(84)90042-1

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MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson's disease

Autor: Ph. Bey, Michael G. Palfreyman, Ian A. McDonald, Mark W. Dudley, John R. Fozard, Monique Zreika

Publikováno v: Journal of Neural Transmission - Parkinson's Disease and Dementia Section. 1:243-254

MDL 72,974, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine, was designed to be a selective inhibitor of monoamine oxidase type B (MAO-B). In vitro, the compound inhibits rat brain mitochondrial MAO in a concentration and time-dependent fashion and show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400788fb920e67e9bdf420aaa9f05d9b
https://doi.org/10.1007/bf02263478

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Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships

Autor: Ian A. McDonald, Philippe Bey, Jean Michel Lacoste, Monique Zreika, Michael G. Palfreyman

Publikováno v: Journal of Medicinal Chemistry. 28:186-193

Seventeen 2-aryl-3-haloallylamine derivatives were prepared and evaluated as inhibitors of monoamine oxidase (MAO, EC 1.4.3.4). The synthesis of these compounds was achieved from either alpha-methylstyrene or ring-substituted phenylacetic acid deriva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b8d795fef6e8ae44ee1b231390049d
https://doi.org/10.1021/jm00380a007

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