Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Monique R Heitmeier"'
Autor:
Monique R Heitmeier, Richard C Hresko, Rachel L Edwards, Michael J Prinsen, Ma Xenia G Ilagan, Audrey R Odom John, Paul W Hruz
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)
Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule inhibitors have lacked promising drug-like structural features necessary for development as c
Externí odkaz:
https://doaj.org/article/5b482186f44d47e980b0f7cc11450eff
Autor:
Monique R. Heitmeier, Maria A. Payne, Carla Weinheimer, Attila Kovacs, Richard C. Hresko, Patrick Y. Jay, Paul W. Hruz
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract GLUT transgenic and knockout mice have provided valuable insight into the role of facilitative glucose transporters (GLUTs) in cardiovascular and metabolic disease, but compensatory physiological changes can hinder interpretation of these mo
Externí odkaz:
https://doaj.org/article/eeb94a2a3685407890ba31775830ba3a
Autor:
Shawna L. McMillin, Parker L. Evans, William M. Taylor, Luke A. Weyrauch, Tyler J. Sermersheim, Steven S. Welc, Monique R. Heitmeier, Richard C. Hresko, Paul W. Hruz, Francoise Koumanov, Geoffrey D. Holman, E. Dale Abel, Carol A. Witczak
Publikováno v:
Biomolecules; Volume 12; Issue 12; Pages: 1734
Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated that mechanical overload, a model of resistance exercise training, increases muscle GLUT1 leve
Autor:
Kartik Shankar, Belgacem Mihi, Phillip I. Tarr, Misty R. Good, Nurmohammad Shaikh, Cassandra B. Higgins, Umesh D. Wankhade, Jeremie L Ferey, Paul W. Hruz, Brian J. DeBosch, Monique R. Heitmeier, Yiming Zhang, Takanobu Higashiyama, Benjamin M. Swarts, Jan R. Crowley, Sree V. Chintapalli, Alicyn I Stothard
Publikováno v:
Gastroenterology
Background & Aims Trehalose is a disaccharide that might be used in the treatment of cardiometabolic diseases. However, trehalose consumption promotes the expansion of Clostridioides difficile ribotypes that metabolize trehalose via trehalose-6-phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab7e3dd3788ff036eca5bbbe3e80a25
https://europepmc.org/articles/PMC7103499/
https://europepmc.org/articles/PMC7103499/
Autor:
Ma. Xenia G. Ilagan, Michael J. Prinsen, Richard C. Hresko, Audrey R. Odom John, Paul W. Hruz, Monique R. Heitmeier, Rachel L. Edwards
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)
PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)
Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule inhibitors have lacked promising drug-like structural features necessary for development as c
Publikováno v:
Diabetes. 67
There are currently 14 known mammalian facilitative glucose transporters (GLUTs) that serve a variety of critical roles in maintaining glucose homeostasis. The ability to potently target glucose transport in an isoform-selective manner is of paramoun
Publikováno v:
Methods in Molecular Biology ISBN: 9781493975068
Glucose is metabolized through anaerobic glycolysis and aerobic oxidative phosphorylation (OXPHOS). Perturbing glucose uptake and its subsequent metabolism can alter both glycolytic and OXPHOS pathways and consequently lactate and/or oxygen consumpti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c99d6600b24f66fb159ee61873ed5ca4
https://doi.org/10.1007/978-1-4939-7507-5_6
https://doi.org/10.1007/978-1-4939-7507-5_6
Autor:
Paul W. Hruz, Audrey R. Odom, Christopher M. Armstrong, Monique R. Heitmeier, Thomas E. Kraft
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:6203-6209
Malaria and HIV infection are coendemic in a large portion of the world and remain a major cause of morbidity and mortality. Growing resistance of Plasmodium species to existing therapies has increased the need for new therapeutic approaches. The Pla
Autor:
Paul W. Hruz, Changyong Wei, Ajay K. Nooka, Mala Shanmugam, Richa Bajpai, Steven T. Rosen, Rama K. Mishra, Gary E. Schiltz, Richard C. Hresko, Shannon M. Matulis, Monique R. Heitmeier
Publikováno v:
Journal of Biological Chemistry. 290:14441-14453
Tumor cells rely on elevated glucose consumption and metabolism for survival and proliferation. Glucose transporters mediating glucose entry are key proximal rate-limiting checkpoints. Unlike GLUT1 that is highly expressed in cancer and more ubiquito
Autor:
Atul D. Jain, Horrick Sharma, Gary E. Schiltz, Mala Shanmugam, Changyong Wei, Richa Bajpai, Paul W. Hruz, Monique R. Heitmeier, Rama K. Mishra, Shannon M. Matulis, Ajay K. Nooka
Cancer cells consume more glucose to fuel metabolic programs fundamental to sustaining their survival, growth and proliferation. Among the fourteen SLC2A family members, GLUTs 1 and 4 are high-affinity glucose transporters. GLUT4 (SLC2A4) is highly e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292f42833c8bb91f2746fb263c68007e
https://europepmc.org/articles/PMC5603412/
https://europepmc.org/articles/PMC5603412/