Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Monique Ponelle"'
Autor:
Serge Moss, Günter Bovermann, Regis Denay, Julien France, Christian Guenat, Lukas Oberer, Monique Ponelle, Harald Schröder
Publikováno v:
CHIMIA, Vol 61, Iss 6 (2007)
The procedure of structure elucidation of natural products at Novartis is discussed. Structure elucidation in an industrial environment has to be time efficient, which is achieved by an optimized workflow and a close integration of all analytical met
Externí odkaz:
https://doaj.org/article/8b3e82858a104bf49df4faba8d86470b
Publikováno v:
Tetrahedron. 54:6415-6426
A novel sesterterpene, YW3699, was isolated from fermentation of the fungus Codinaea simplex. Based on spectroscopic evidence, including UV, IR, FAB-MS, ESI-HRMS, 1H and 13C NMR, DQ-COSY, HQSC and HMBC, YW3699 was shown to have an unusual tetracarboc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc7b2e2ac38cdd1986e2cef31850bcee
https://doi.org/10.1016/s0040-4020(98)00322-6
https://doi.org/10.1016/s0040-4020(98)00322-6
Publikováno v:
Helvetica Chimica Acta. 80:2157-2167
As one of the regulatory gene products in the HIV-1 genome, Rev protein must be translocated from the nucleus to the cytoplasm to exert its function. Therefore, inhibition of Rev protein translocation could be a useful target for HIV therapy. An extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db8ac5c67bf34f48475879d273b2dfb0
https://doi.org/10.1002/hlca.19970800715
https://doi.org/10.1002/hlca.19970800715
Publikováno v:
Enzyme and Microbial Technology. 21:405-412
In order to obtain derivatives of rapamycin, a total of 28 bacterial and 72 fungal strains were screened for their ability to transform rapamycin. In the course of this screening, the already known derivatives 39-o-demethylrapamycin, 27-o-demethylrap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb429e54f9e9e395eec77673ddb545e
https://doi.org/10.1016/s0141-0229(97)00013-6
https://doi.org/10.1016/s0141-0229(97)00013-6
Autor:
Liliane Gschwind, Susi Wehrli, Wolfgang Schilling, Theodor Fehr, Albert Enz, Lukas Oberer, Walter Schuler, Jean-Jacques Sanglier, Gerhard Zenke, Monique Ponelle, Valerie Quesniaux
Publikováno v:
The Journal of Antibiotics. 50:893-899
Two novel metabolites, cymbimicins A and B, were isolated from the culture broth of a strain of Micromonospora sp. by screening for cyclophilin binding metabolites from actinomycete strains. Cymbimicin A binds to cyclophilin A with a high affinity si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66604f008cd27e698b401b85ad960d77
https://doi.org/10.7164/antibiotics.50.893
https://doi.org/10.7164/antibiotics.50.893
Autor:
Wolfgang Schilling, J.‐J. Sanglier, Liliane Gschwind, Monique Ponelle, T. Fehr, Walter Schuler, C. Wioland
Publikováno v:
ChemInform. 27
5 novel ascomycin-like compounds, antascomicins A, B, C, D and E were isolated from a strain of Micromonospora. The antascomicins bind strongly to the FK506-binding protein FKBP12 and antagonize the immunosuppressive activity of FK506 and rapamycin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3eb6b0490a991abbd282546b50f27d1
https://doi.org/10.1002/chin.199635234
https://doi.org/10.1002/chin.199635234
Publikováno v:
ChemInform. 29
As one of the regulatory gene products in the HIV-1 genome, Rev protein must be translocated from the nucleus to the cytoplasm to exert its function. Therefore, inhibition of Rev protein translocation could be a useful target for HIV therapy. An extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732818f0228f851b34cb6792e188bc7c
https://doi.org/10.1002/chin.199804230
https://doi.org/10.1002/chin.199804230
Publikováno v:
ChemInform. 29
A novel sesterterpene, YW3699, was isolated from fermentation of the fungus Codinaea simplex. Based on spectroscopic evidence, including UV, IR, FAB-MS, ESI-HRMS, 1H and 13C NMR, DQ-COSY, HQSC and HMBC, YW3699 was shown to have an unusual tetracarboc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81709770e9202d67d491ebcbf216172a
https://doi.org/10.1002/chin.199836223
https://doi.org/10.1002/chin.199836223
Autor:
Matthias Kittelmann, Cleber V. Ursini, Toyokazu Yoshida, Yoshinori Kondo, Serge Parel, Maria Serrano Correia, Sheng Yuan, C. Akira Horiuchi, Andrew S. Lamm, John P. N. Rosazza, Renata P. Limberger, Oreste Ghisalba, Jens Schrader, Takamitsu Utsukihara, Andreas Schmid, Yi‐Jun Dai, Anton Kuhn, Jürgen Kühnöl, Katja Buehler, Toru Nagasawa, Monique Ponelle, Koichi Mitsukura, Marco Antonio Mirata, Arshdeep Khare, Reiner Aichholz, Paulo J. S. Moran, J. Augusto R. Rodrigues, Kevin E. O’Connor, Louise C. Nolan
Publikováno v:
Practical Methods for Biocatalysis and Biotransformations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fafe16ff51e960c7a04fd5bfa9023ceb
https://doi.org/10.1002/9780470748589.ch12
https://doi.org/10.1002/9780470748589.ch12
Autor:
John R. Fozard, Karl-Heinz Buchheit, Gerhard Zenke, Markus Zollinger, Monique Ponelle, Walter Schuler, Olivier Lohse, Christoph Walker, Albert Enz, Lazzaro Mazzoni, Hartmut Zehender, Alfred Zimmerlin, Rene Hersperger, Salvatore Cammisuli, Alain Schweitzer
Publikováno v:
Journal of medicinal chemistry. 47(20)
One of the characteristic features of asthma is a persistent pulmonary inflammation, with increased numbers of eosinophils and activated T-lymphocytes in the airways. T-helper cells of the Th2 phenotype play a pivotal role in the pathogenesis of asth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ccc7f9c26cf159b90d07ddfe840a99
https://pubmed.ncbi.nlm.nih.gov/15369399
https://pubmed.ncbi.nlm.nih.gov/15369399