Mild Behavioral Impairment and Amyloid-Β Accumulation in the Amygdala Precede Cognitive Decline in Juvenile Male 3xtg-Ad Mice

Autor: Monique Patricio Singulani, Ana Flávia Fernandes Ferreira, Carolina Parga Martins Pereira, Rita Mara Soares Gutierrez, Leda Leme Talib, Orestes V. Forlenza, Rosana Camarini, Luis Roberto Giorgetti Britto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8eb61b7aba08aefe00de53c9df2815ad
https://doi.org/10.2139/ssrn.4346250

Microglial depletion exacerbates motor impairment and dopaminergic neuron loss in a 6-OHDA model of Parkinson's disease

Autor: Carolina Parga Martins Pereira, José Francis-Oliveira, Monique Patricio Singulani, Ana Flávia Fernandes Ferreira, Luiz Roberto G. Britto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8599241f730df5d77f0454890ffc545
https://doi.org/10.1016/j.jneuroim.2023.578019

Neuroplasticity induced by the retention period of a complex motor skill learning in rats

Autor: Caroline Cristiano Real, Monique Patricio Singulani, Raquel Simoni Pires, Sandra Regina Alouche, Adaneuda Silva Britto Sampaio, Rita Mara Soares Gutierrez, Luiz R.G. Britto

Publikováno v: Sampaio, A S B, Real, C C, Gutierrez, R M S, Singulani, M P, Alouche, S R, Britto, L R & Pires, R S 2021, ' Neuroplasticity induced by the retention period of a complex motor skill learning in rats ', Behavioural Brain Research, vol. 414, 113480 . https://doi.org/10.1016/j.bbr.2021.113480

Learning complex motor skills is an essential process in our daily lives. Moreover, it is an important aspect for the development of therapeutic strategies that refer to rehabilitation processes since motor skills previously acquired can be transferr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352974b74ff611aaa7ecb08e66d9109d
https://pubmed.ncbi.nlm.nih.gov/34302881

Oral benfotiamine reverts cognitive deficit and increase thiamine diphosphate levels in the brain of a rat model of neurodegeneration

Autor: Monique Patricio Singulani, Alisson Carvalho de Gonçalves, Guilherme Vannucchi Portari, Ruan Carlos Macêdo de Moraes, Andréa da Silva Torrão

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

It is well known that patients with Alzheimer's disease (AD) have imbalances in blood thiamine concentrations and lower activity of thiamine-dependent enzymes. Benfotiamine, a more bioavailable thiamine analog, has been proposed as an alternative to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a4819785811e92ba754eeb7db0c849
https://pubmed.ncbi.nlm.nih.gov/32987117

Impairment of PGC-1α-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease

Autor: Luciane C. Alberici, Monique Patricio Singulani, Gustavo Duarte Ferrari, Carolina Pereira, Ana Flávia Fernandes Ferreira, P. C. Garcia, Luiz R.G. Britto

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Impairment of mitochondrial biogenesis and mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD). However, the extent to which the impairment of mitochondrial biogenesis influences mitochondrial dysfunction at the onset and dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4672439a4222da4f21420209b8d2c90b