Výsledky vyhledávání - "Monique P Gelderman"

Akademický článek

P38 mitogen activated protein kinase inhibitor improves platelet in vitro parameters and in vivo survival in a SCID mouse model of transfusion for platelets stored at cold or temperature cycled conditions for 14 days.

Autor: Andrey Skripchenko, Monique P Gelderman, Jaroslav G Vostal

Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0250120 (2021)

Platelets for transfusion are stored at room temperature (20-24°C) up to 7 days but decline in biochemical and morphological parameters during storage and can support bacterial proliferation. This decline is reduced with p38MAPK inhibitor, VX-702. S

Externí odkaz: https://doaj.org/article/bf111bdcead1423d9f64ee52e9a89b9d

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Akademický článek

Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model.

Autor: Sandeep N Shah, Monique P Gelderman, Emily M A Lewis, John Farrel, Francine Wood, Michael Brad Strader, Abdu I Alayash, Jaroslav G Vostal

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0166657 (2016)

Reliance on volunteer blood donors can lead to transfusion product shortages, and current liquid storage of red blood cells (RBCs) is associated with biochemical changes over time, known as 'the storage lesion'. Thus, there is a need for alternative

Externí odkaz: https://doaj.org/article/5f12657998fd4fa198fa9429ad7608e4

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Akademický článek

Adverse effects of fullerenes on endothelial cells: Fullerenol C60(OH)24 induced tissue factor and ICAM-1 membrane expression and apoptosis in vitro

Autor: Monique P Gelderman, Olga Simakova, Jeffrey D Clogston, Anil K Patri, Sheena F Siddiqui, et al

Publikováno v: International Journal of Nanomedicine, Vol 2008, Iss Issue 1, Pp 59-68 (2008)

Monique P Gelderman1, Olga Simakova2, Jeffrey D Clogston3, Anil K Patri3, Sheena F Siddiqui1, Alexander C Vostal1, Jan Simak11CBER, FDA, Rockville, MD, USA; 2School of Medicine, USUHS, Bethesda, MD, USA; 3Nanotechnology Characterization Lab, Advanced

Externí odkaz: https://doaj.org/article/98ec3433c80847bf919c872329341cbe

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Akademický článek

Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury.

Autor: Xuan Chi, Li Zhi, Monique P Gelderman, Jaroslav G Vostal

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44829 (2012)

We previously reported that ultraviolet light B (UVB)-treated human platelets (hPLTs) can cause acute lung injury (ALI) in a two-event SCID mouse model in which the predisposing event was Lipopolysaccharide (LPS) injection and the second event was in

Externí odkaz: https://doaj.org/article/78bbac038bcb42ac94b09f66e70ed4cc

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Akademický článek

Non-ionizing 405 nm Light as a Potential Bactericidal Technology for Platelet Safety: Evaluation of in vitro Bacterial Inactivation and in vivo Platelet Recovery in Severe Combined Immunodeficient Mice

Autor: Michelle Maclean, Monique P. Gelderman, Sandhya Kulkarni, Rachael M. Tomb, Caitlin F. Stewart, John G. Anderson, Scott J. MacGregor, Chintamani D. Atreya

Publikováno v: Frontiers in Medicine, Vol 6 (2020)

Bacterial contamination of ex vivo stored platelets is a cause of transfusion-transmitted infection. Violet-blue 405 nm light has recently demonstrated efficacy in reducing the bacterial burden in blood plasma, and its operational benefits such as no

Externí odkaz: https://doaj.org/article/f48f1555bea64910b4124ccbdcfcbbe2

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Akademický článek

Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous b1/b2 globin gene deletion) mice

Autor: Monique P. Gelderman, Jin Hyen Baek, Ayla Yalamanoglu, Michele Puglia, Florence Vallelian, Bo Burla, Jaroslav Vostal, Dominik J. Schaer, Paul W. Buehler

Publikováno v: Haematologica, Vol 100, Iss 5 (2015)

Intermediate beta-thalassemia has a broad spectrum of sequelae and affected subjects may require occasional blood transfusions over their lifetime to correct anemia. Iron overload in intermediate beta-thalassemia results from a paradoxical intestinal

Externí odkaz: https://doaj.org/article/fb371751f9374b33b387ed22e2ddbc2f

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