Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Monique Hooley"'
Autor:
María Pagnon de la Vega, Stina Syvänen, Vilmantas Giedraitis, Monique Hooley, Evangelos Konstantinidis, Silvio R. Meier, Johanna Rokka, Jonas Eriksson, Ximena Aguilar, Tara L. Spires-Jones, Lars Lannfelt, Lars N. G. Nilsson, Anna Erlandsson, Greta Hultqvist, Martin Ingelsson, Dag Sehlin
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Deposition of amyloid beta (Aβ) into plaques is a major hallmark of Alzheimer’s disease (AD). Different amyloid precursor protein (APP) mutations cause early-onset AD by altering the production or aggregation properties of Aβ. We recentl
Externí odkaz:
https://doaj.org/article/e1e6c9096c0f4e3e9f714a2564198215
Autor:
Zoeb Jiwaji, Sachin S. Tiwari, Rolando X. Avilés-Reyes, Monique Hooley, David Hampton, Megan Torvell, Delinda A. Johnson, Jamie McQueen, Paul Baxter, Kayalvizhi Sabari-Sankar, Jing Qiu, Xin He, Jill Fowler, James Febery, Jenna Gregory, Jamie Rose, Jane Tulloch, Jamie Loan, David Story, Karina McDade, Amy M. Smith, Peta Greer, Matthew Ball, Peter C. Kind, Paul M. Matthews, Colin Smith, Owen Dando, Tara L. Spires-Jones, Jeffrey A. Johnson, Siddharthan Chandran, Giles E. Hardingham
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Alzheimer’s disease is associated with changes in astrocytes. Here the authors investigated the astrocyte translatome associated with amyloid-ß and tau pathology.
Externí odkaz:
https://doaj.org/article/3684566e972d48bda37be69378c00e42
Autor:
Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d’Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M. Henstridge, Giles E. Hardingham, Tara L. Spires-Jones
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3592-3604.e5 (2019)
Summary: A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotype
Externí odkaz:
https://doaj.org/article/5c607706c23f4f7d92a682e925ca0372
Autor:
Angela CC Jochems, Carmen Arteaga, Francesca M Chappell, Tuula Ritakari, Monique Hooley, Fergus N Doubal, Susana Muñoz Maniega, Joanna M Wardlaw
Publikováno v:
Jochems, A, Arteaga Reyes, C, Chappell, F M, Ritakari, T, Hooley, M, Doubal, F, Muñoz Maniega, S & Wardlaw, J M 2022, ' Longitudinal changes of white matter hyperintensities in sporadic small vessel disease: a systematic review and meta-analysis ', medrXiv . https://doi.org/10.1212/WNL.0000000000201205, https://doi.org/10.1101/2022.03.22.22272696
Background and objectives.White matter hyperintensities (WMH) are frequent imaging features of small vessel disease (SVD) and related to poor clinical outcomes. WMH progression over time is well described, but regression was also noted recently, alth
Autor:
Makis Tzioras, Michael Daniels, Caitlin Davies, Monique Hooley, Xin He, Owen R. Dando, Giles Hardingham, Barry McColl, Tara L. Spires‐Jones
Publikováno v:
Alzheimer's & Dementia. 17
Autor:
Tara L. Spires-Jones, Monique Hooley, Colin Smith, Anton-Fernandez A, Jamie Rose, Susan M. Catalano, Makis Tzioras, Rosemary J. Jackson, J. H. Catterson, Nicholas J. Izzo, Claire L. Davies, Tempelaar R, Martí Colom-Cadena, Jane Tulloch, Sophie Dunnett
Synapse loss correlates with cognitive decline in Alzheimer’s disease (AD), and soluble amyloid beta (Aβ) is implicated in synaptic dysfunction and loss. An important knowledge gap is the lack of understanding of how synaptic accumulation of Aβ l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed92cd0edcf16138aa25188d4a80a123
https://doi.org/10.1101/2021.02.01.428238
https://doi.org/10.1101/2021.02.01.428238
Residues W320 and Y328 within the binding site of the μ-opioid receptor influence opiate ligand bias
Autor:
Rubben Torella, Monique Hooley, J. Daniel Hothersall, Sarah A. Nickolls, Alastair J. H. Brown, Gordon McMurray, Sian Humphreys
Publikováno v:
Neuropharmacology. 118:46-58
The development of G protein-biased agonists for the μ-opioid receptor (MOR) offers a clear drug discovery rationale for improved analgesia and reduced side-effects of opiate pharmacotherapy. However, our understanding of the molecular mechanisms go
Autor:
C. McKenzie, Jane Tulloch, Monique Hooley, Rosemary J. Jackson, Sadaf Sohrabi, Marie d'Orange, Elizabeth Allison, Kimberly Abt, Makis Tzioras, Anna J. Stevenson, Maria P. Fjeldstad, Sophie Dunnett, Will Calkin, Colin Smith, Giles E. Hardingham, Owen Dando, Caitlin Davies, Leo Murison, Eleanor K. Pickett, Tara L. Spires-Jones, Iris Oren, Christopher M. Henstridge, Jamie McQueen, Abigail G. Herrmann, Oliver Hardt, Jamie Rose, Pooja Jain
Publikováno v:
SSRN Electronic Journal.
SummaryOne of the key knowledge gaps blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) and tau cooperate in causing disease phenotypes. Within a mouse tau deficient ba
Autor:
Colin Smith, Caitlin Davies, Rosemary J. Jackson, Makis Tzioras, Sadaf Sohrabi, Abigail G. Herrmann, Monique Hooley, Declan King, Pooja Jain, Jamie McQueen, Iris Oren, Oliver Hardt, Tara L. Spires-Jones, Christopher M. Henstridge, Eleanor K. Pickett, Anna J. Stevenson, Sophie Dunnett, Maria P. Fjeldstad, Jamie Rose, Marie d'Orange, Giles E. Hardingham, Owen Dando, Alejandro Anton-Fernandez, Martí Colom-Cadena, C. McKenzie, Jane Tulloch, Leo Murison, Will Calkin, Elizabeth Allison, Kimberly Abt
Publikováno v:
Cell Reports
Cell Reports, Vol 29, Iss 11, Pp 3592-3604.e5 (2019)
Pickett, E K, Herrmann, A G, McQueen, J, Abt, K, Dando, O, Tulloch, J, Jain, P, Dunnett, S, Sohrabi, S, Fjeldstad, M P, Calkin, W, Murison, L, Jackson, R J, Tzioras, M, Stevenson, A, d'Orange, M, Hooley, M, Davies, C, Colom Cadena, M, Anton Fernandez, A, King, D, Oren, I, Rose, J, McKenzie, C-A, Allison, E, Smith, C, Hardt, O, Henstridge, C M, Hardingham, G E & Spires-Jones, T L 2019, ' Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease ', Cell Reports, vol. 29, no. 11, pp. 3592-3604.E5 . https://doi.org/10.1016/j.celrep.2019.11.044
Cell Reports, Vol 29, Iss 11, Pp 3592-3604.e5 (2019)
Pickett, E K, Herrmann, A G, McQueen, J, Abt, K, Dando, O, Tulloch, J, Jain, P, Dunnett, S, Sohrabi, S, Fjeldstad, M P, Calkin, W, Murison, L, Jackson, R J, Tzioras, M, Stevenson, A, d'Orange, M, Hooley, M, Davies, C, Colom Cadena, M, Anton Fernandez, A, King, D, Oren, I, Rose, J, McKenzie, C-A, Allison, E, Smith, C, Hardt, O, Henstridge, C M, Hardingham, G E & Spires-Jones, T L 2019, ' Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease ', Cell Reports, vol. 29, no. 11, pp. 3592-3604.E5 . https://doi.org/10.1016/j.celrep.2019.11.044
Summary A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotypes