Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Monique Delpech"'
Autor:
Monique Delpech, Pascual Ferrara, David Shire, Marielle Portier, Aimée Kernéis, Christine Carillon, Gérard Le Fur, Bernard Calandra
Publikováno v:
European Journal of Pharmacology. 374:445-455
It has long been established that the cannabinoid CB1 receptor transduces signals through a pertussis toxin-sensitive Gi/Go inhibitory pathway. Although there have been reports that the cannabinoid CB1 receptor can also mediate an increase in cyclic
Autor:
Annick Josse, Pascual Ferrara, Patricia Angelloz-Nicoud, Pascal Leplatois, David Shire, Monique Delpech, Edgardo A. Ferrán, Florence Pecceu, Constantino Diaz, Gérard Loison, Marc Pascal, Marinette Lecomte
Publikováno v:
Molecular informatics. 30(4)
We discovered a constitutively activating mutation (CAM) V308E for the neurotensin NT1 receptor. Molecular dynamics (MD) performed for the CAM NT1-V308E exhibiting a high spontaneous activity, and for the wild-type NT1 without basal activity, show dr
Autor:
Gérard Le Fur, Pascual Ferrara, Xavier Dumont, Monique Delpech, David Shire, Bernard Calandra, Mourad Kaghad, Daniel Caput
Publikováno v:
The Journal of biological chemistry. 271(12)
The antagonist SR 141716A has a high specificity for the central CB1 cannabinoid receptor and negligeable affinity for the peripheral CB2 receptor, making it an excellent tool for probing receptor structure-activity relationships. From binding experi